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SPG21 and CRYAA
Number of citations of the paper that reports this interaction (PMID
25416956
)
0
Data Source:
BioGRID
(two hybrid)
SPG21
CRYAA
Gene Name
spastic paraplegia 21 (autosomal recessive, Mast syndrome)
crystallin, alpha A
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Endosome Membrane
Trans-Golgi Network Transport Vesicle
Nucleus
Cytoplasm
Extracellular Vesicular Exosome
Molecular Function
Protein Binding
CD4 Receptor Binding
Structural Constituent Of Eye Lens
Protein Binding
Identical Protein Binding
Metal Ion Binding
Unfolded Protein Binding
Biological Process
Antigen Receptor-mediated Signaling Pathway
Visual Perception
Negative Regulation Of Intracellular Transport
Protein Refolding
Negative Regulation Of Apoptotic Process
Response To Stimulus
Protein Homooligomerization
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions
37 interactors:
AGTRAP
AKIRIN2
ARL6IP1
ATPAF2
CCDC102B
CCDC33
CD4
CMTM5
CRYAA
CTPS2
CUTC
DTX2
DTX3L
EFHC2
FAM114A1
GGA2
GSK3A
IKZF3
INCA1
KRT15
MID2
MTMR9
PRPS1
RABAC1
REEP6
RTN4
S100B
SPRED2
TCF12
TCF4
TFG
TRAF1
TRAF2
TRIM23
TRIM54
TRIM9
ZNF263
17 interactors:
ALB
BCL2L1
CRYAB
CRYBA1
CRYBB2
CRYGC
CRYGD
CRYZ
CS
GORASP2
HSPB1
HSPB2
LALBA
MIP
SDCBP
SPG21
WDYHV1
Entrez ID
51324
1409
HPRD ID
10492
00427
Ensembl ID
ENSG00000090487
ENSG00000160202
Uniprot IDs
Q9NZD8
E9PHE4
P02489
PDB IDs
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Apoptotic Process
Protein Ubiquitination
Regulation Of Cell Death
Protein Modification By Small Protein Conjugation
Negative Regulation Of Developmental Growth
Innate Immune Response
Positive Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of Striated Muscle Tissue Development
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Positive Regulation Of Interleukin-2 Production
Positive Regulation Of Cell Death
Immune Response
Negative Regulation Of Organ Growth
Negative Regulation Of UDP-glucose Catabolic Process
Induction By Virus Of Host Cell-cell Fusion
Protein Palmitoleylation
Regulation Of Intracellular Signal Transduction
Negative Regulation Of Muscle Cell Differentiation
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of Striated Muscle Tissue Development
Regulation Of Cellular Localization
Negative Regulation Of Muscle Organ Development
Regulation Of Signal Transduction
Positive Regulation Of Apoptotic Signaling Pathway
Regulation Of Extrinsic Apoptotic Signaling Pathway
Pyrimidine Nucleotide Biosynthetic Process
Regulation Of Intracellular Transport
Negative Regulation Of Cell Differentiation
Regulation Of Protein Kinase Activity
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Negative Regulation Of Type B Pancreatic Cell Development
Negative Regulation Of SNARE Complex Assembly
Catenin Import Into Nucleus
Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition
Urate Biosynthetic Process
'de Novo' CTP Biosynthetic Process
Glycogen Metabolic Process
Regulation Of Kinase Activity
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Regulation Of Cell Differentiation
Positive Regulation Of Protein Binding
Regulation Of Skeletal Muscle Tissue Development
Regulation Of Cellular Ketone Metabolic Process
Gliogenesis
Negative Regulation Of Growth
Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process
Visual Perception
Sensory Perception Of Light Stimulus
Camera-type Eye Development
Eye Development
Lens Development In Camera-type Eye
Sensory Organ Development
Sensory Perception
Cellular Response To Gamma Radiation
Neurological System Process
Bile Acid And Bile Salt Transport
Response To Gamma Radiation
Cellular Response To Ionizing Radiation
Apoptotic Process In Bone Marrow
Retina Homeostasis
Maintenance Of Mitochondrion Location
Lactose Biosynthetic Process
Response To Platinum Ion
Hemolysis By Symbiont Of Host Erythrocytes
Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Response To Stimulus
Interaction With Host
Organ Development
Positive Regulation Of Extracellular Vesicular Exosome Assembly
Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway
Suppression By Virus Of Host Apoptotic Process
Anatomical Structure Development
Negative Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Positive Regulation Of Cell Migration By Vascular Endothelial Growth Factor Signaling Pathway
Disaccharide Metabolic Process
Canalicular Bile Acid Transport
Positive Regulation Of Behavior
Monocarboxylic Acid Transport
Response To Unfolded Protein
Regulation Of Extracellular Vesicular Exosome Assembly
Negative Regulation Of Cell Death
Cellular Response To Radiation
System Development
Response To Ionizing Radiation
Protein Processing Involved In Protein Targeting To Mitochondrion
Response To Cycloheximide
Cellular Process Regulating Host Cell Cycle In Response To Virus
Mitochondrial Transport
Regulation Of Intrinsic Apoptotic Signaling Pathway
Tubulin Complex Assembly
Positive Regulation Of Endothelial Cell Chemotaxis
Negative Regulation Of Execution Phase Of Apoptosis
Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep
Response To Stress
Tagcloud
?
aiims
beaded
bfsp1
cataract
congenital
cryab
cryba1
cryba4
crybb1
crybb2
crybb3
crygs
crystallin
cx
d85n
delhi
e155k
e75k
expands
filament
fourteen
gja3
gja8
m1v
ophthalmic
sciences
studio
transparency
y67n
Tagcloud (Difference)
?
aiims
beaded
bfsp1
cataract
congenital
cryab
cryba1
cryba4
crybb1
crybb2
crybb3
crygs
crystallin
cx
d85n
delhi
e155k
e75k
expands
filament
fourteen
gja3
gja8
m1v
ophthalmic
sciences
studio
transparency
y67n
Tagcloud (Intersection)
?