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CRYAA and MCM7
Number of citations of the paper that reports this interaction (PubMedID
24453475
)
30
Data Source:
BioGRID
(pull down)
CRYAA
MCM7
Description
crystallin alpha A
minichromosome maintenance complex component 7
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Protein-containing Complex
Chromosome, Telomeric Region
Chromatin
Nucleus
Nucleoplasm
Chromosome
Nucleolus
Membrane
MCM Complex
CMG Complex
Molecular Function
Structural Molecule Activity
Structural Constituent Of Eye Lens
Protein Binding
Identical Protein Binding
Metal Ion Binding
Unfolded Protein Binding
Nucleotide Binding
DNA Binding
DNA Helicase Activity
Single-stranded DNA Binding
Helicase Activity
Protein Binding
ATP Binding
Hydrolase Activity
ATP Hydrolysis Activity
Single-stranded DNA Helicase Activity
Biological Process
Response To Hypoxia
Lens Development In Camera-type Eye
Lens Morphogenesis In Camera-type Eye
Apoptotic Process
Mitochondrion Organization
Actin Filament Organization
Microtubule-based Process
Tubulin Complex Assembly
Visual Perception
Response To Heat
Negative Regulation Of Gene Expression
Positive Regulation Of Cell Growth
Negative Regulation Of Intracellular Transport
Protein Refolding
Response To Hydrogen Peroxide
Camera-type Eye Development
Negative Regulation Of Apoptotic Process
Embryonic Camera-type Eye Morphogenesis
Protein Stabilization
Apoptotic Process Involved In Morphogenesis
Response To UV-A
Lens Fiber Cell Morphogenesis
Double-strand Break Repair Via Break-induced Replication
DNA Replication
DNA Replication Initiation
DNA Strand Elongation Involved In DNA Replication
DNA Damage Response
Cell Population Proliferation
Response To Xenobiotic Stimulus
Regulation Of DNA-templated DNA Replication Initiation
Regulation Of Phosphorylation
Cellular Response To Epidermal Growth Factor Stimulus
Cellular Response To Xenobiotic Stimulus
Pathways
Activation of ATR in response to replication stress
Unwinding of DNA
Assembly of the pre-replicative complex
Assembly of the pre-replicative complex
Orc1 removal from chromatin
Activation of the pre-replicative complex
Switching of origins to a post-replicative state
Drugs
Diseases
GWAS
Age-related nuclear cataracts (
24951543
33311586
)
Diastolic blood pressure (
27618452
27841878
28135244
28739976
)
Metabolite levels (
23823483
)
Systolic blood pressure (
27618452
27841878
28739976
)
Brain morphology (MOSTest) (
32665545
)
Refractive error (
32231278
)
Subcortical volume (MOSTest) (
32665545
)
Interacting Genes
134 interacting genes:
-
ADPRHL1
AKT3
ALB
ALDH1L2
ANKRD44
APPL2
ARFGAP1
ARMCX4
ARRDC1-AS1
ATG16L1
BCL2L1
BORA
BTRC
CAMKK2
CD209
CDC40
CEBPZ
CENPH
CER1
CNOT8
COPB2
CRTAC1
CRYAB
CRYBA1
CRYBB2
CRYGC
CRYGD
CRYZ
CS
CSTF2T
DCAF11
DCAF8
DCK
DDX3X
DUS4L
E2F7
EEPD1
ETFB
EYA4
FAM131B
FAM131C
FAM182A
FASN
GIGYF2
GLYATL1
GNAI2
GORASP2
GSTZ1
HABP4
HCLS1
HSPB1
HSPB2
IGHG1
IGKV1-5
JKAMP
KBTBD12
KIZ
KNG1
LALBA
LARP6
LIMA1
MAP3K7CL
MAPKBP1
MCM7
MCRS1
MINDY1
MIP
MPHOSPH6
MTERF4
MYO5C
NAT9
NCF4
NTAQ1
NUP43
OSBPL3
OTOGL
OTULIN
PABIR2
PAFAH1B1
PCYT2
PHC1
PLAUR
PMS2
PRM2
PSMB6
PTPN2
PTTG2
QRICH1
RAB24
RAB29
RAB3C
RAB40B
RAB43
RAD51
RBBP7
RNASEH1
RNGTT
RPS6KA5
SDCBP
SEC24C
SEH1L
SESN2
SGCD
SLC20A1
SLC25A25
SLC25A26
SLC25A28
SPG21
SSBP4
SULF1
SYK
TASL
TEAD4
TFDP1
TGOLN2
TLE4
TMEM254
TMEM52B
TSR3
TTC27
TTC39B
TUBAL3
TUBGCP5
UBR2
UPP1
WDR55
WDR83
WIPI2
WWC2
ZIM2
ZNF3
ZNF639
ZSCAN20
79 interacting genes:
ABI2
AK8
APP
ASB8
C8orf34
CCDC102B
CCND1
CCNH
CDC42
CDC45
CDC6
CDC7
CDK7
CDKN1B
CEBPA
CEP68
CHEK1
COG6
CRLS1
CRYAA
DBF4
DNAAF6
DUX4
ELOC
ESCO2
FHL2
GOLGA2
H3-4
HIF1A
IKBKG
IKZF3
INTS6
KIFC3
LINC01554
LNX2
LRR1
MAGEA6
MBIP
MCM10
MCM2
MCM3
MCM4
MCM5
MCM6
MCM8
MEOX2
MIPOL1
MNAT1
NAB2
NFKBIA
ORC1
ORC2
ORC3
ORC4
ORC5
ORC6
PLK1
PNMA1
RAD17
RB1
RBL1
RBL2
RBM8A
RBPMS
RINT1
RNF181
RPA1
SMC1A
SNTA1
SP2
SSX2IP
TFIP11
TREX1
TRIM27
TRIM54
TRIM63
UBE3A
UBQLN1
USHBP1
Entrez ID
1409
4176
HPRD ID
00427
01154
Ensembl ID
ENSG00000160202
ENSG00000166508
Uniprot IDs
A0A8C8KJZ9
P02489
A0A0S2Z4A5
C6EMX8
C9J8M6
P33993
PDB IDs
6T1R
6XTX
6XTY
7PFO
7PLO
7W1Y
7W68
8B9D
8RWV
8S09
8S0A
8S0B
8S0D
8S0E
8S0F
8W0E
8W0F
8W0G
8W0I
9CAQ
Enriched GO Terms of Interacting Partners
?
Structural Constituent Of Eye Lens
Lens Development In Camera-type Eye
DNA Replication Initiation
DNA Replication
DNA Replication Origin Binding
DNA Metabolic Process
Nuclear Origin Of Replication Recognition Complex
Chromosome, Telomeric Region
Nucleoplasm
Regulation Of DNA Replication
Origin Recognition Complex
Double-strand Break Repair Via Break-induced Replication
Nucleus
DNA Damage Response
Regulation Of Cell Cycle Phase Transition
Regulation Of Mitotic Cell Cycle Phase Transition
CMG Complex
MCM Complex
Regulation Of Mitotic Cell Cycle
Regulation Of Nucleobase-containing Compound Metabolic Process
Nucleic Acid Metabolic Process
Negative Regulation Of Cell Cycle
Single-stranded DNA Binding
Regulation Of Cell Cycle Process
DNA Repair
Negative Regulation Of Mitotic Cell Cycle
Negative Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Cell Cycle
Negative Regulation Of Cell Cycle Process
Negative Regulation Of Cell Cycle Phase Transition
Double-strand Break Repair Via Homologous Recombination
Regulation Of DNA Metabolic Process
Cellular Response To Stress
Recombinational Repair
Mitotic DNA Integrity Checkpoint Signaling
Chromosome
Nucleobase-containing Compound Metabolic Process
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Double-strand Break Repair
Regulation Of DNA-templated DNA Replication Initiation
Regulation Of Cell Cycle G1/S Phase Transition
DNA Recombination
Single-stranded DNA Helicase Activity
Regulation Of Primary Metabolic Process
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Regulation Of Cell Cycle G2/M Phase Transition
Transcription Factor TFIIK Complex
Mitotic G2/M Transition Checkpoint
CAK-ERCC2 Complex
Mitotic DNA Replication Initiation
Regulation Of Lipid Kinase Activity
Macromolecule Metabolic Process
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