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SPG21 and IKZF3
Number of citations of the paper that reports this interaction (PMID
25416956
)
0
Data Source:
BioGRID
(two hybrid)
SPG21
IKZF3
Gene Name
spastic paraplegia 21 (autosomal recessive, Mast syndrome)
IKAROS family zinc finger 3 (Aiolos)
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Endosome Membrane
Trans-Golgi Network Transport Vesicle
Nucleus
Cytoplasm
Plasma Membrane
Molecular Function
Protein Binding
CD4 Receptor Binding
Sequence-specific DNA Binding Transcription Factor Activity
Protein Binding
Protein Homodimerization Activity
Sequence-specific DNA Binding
Metal Ion Binding
Protein Heterodimerization Activity
Biological Process
Antigen Receptor-mediated Signaling Pathway
Transcription, DNA-templated
Regulation Of Transcription From RNA Polymerase II Promoter
Mesoderm Development
Regulation Of B Cell Proliferation
B Cell Activation
Regulation Of Apoptotic Process
Regulation Of B Cell Differentiation
Regulation Of Lymphocyte Differentiation
Pathways
Drugs
Diseases
GWAS
Crohn's disease (
21102463
)
Inflammatory bowel disease (
23128233
)
Primary biliary cirrhosis (
19458352
23000144
20639880
)
Rheumatoid arthritis (
20453842
)
Systemic lupus erythematosus and Systemic sclerosis (
23740937
)
Ulcerative colitis (
21297633
)
Protein-Protein Interactions
37 interactors:
AGTRAP
AKIRIN2
ARL6IP1
ATPAF2
CCDC102B
CCDC33
CD4
CMTM5
CRYAA
CTPS2
CUTC
DTX2
DTX3L
EFHC2
FAM114A1
GGA2
GSK3A
IKZF3
INCA1
KRT15
MID2
MTMR9
PRPS1
RABAC1
REEP6
RTN4
S100B
SPRED2
TCF12
TCF4
TFG
TRAF1
TRAF2
TRIM23
TRIM54
TRIM9
ZNF263
71 interactors:
ABLIM3
AES
AKAP9
AQP1
ARMC7
ARNT2
ATPAF2
BCAS2
BCL2L1
C1orf109
CABP5
CDKN1A
CDKN2D
CHCHD2
CHD3
DGCR6
EFHC1
EMC2
EXOC8
EXOSC5
FANCL
FARS2
FBF1
GEM
GRB2
HNRNPF
HRAS
IKZF1
IKZF4
IKZF5
ING5
KAT5
KRT19
LGALS14
LMO1
LMO2
MAGOHB
MORN3
MRPL28
MRPL53
NATD1
NEK6
OAZ3
OSGIN1
PCID2
PFDN5
PIK3R2
PIN1
POLM
POLR1C
PPP1R16B
PRKAA1
PRKAB2
PSMA1
RAD51D
RBBP8
RCOR3
RHOA
SPG21
STAMBPL1
STK16
STX11
TBC1D22B
TCAF1
TEKT4
TRAPPC6A
TRIM42
TSSK3
TSTD2
UBE2I
ZGPAT
Entrez ID
51324
22806
HPRD ID
10492
05869
Ensembl ID
ENSG00000090487
Uniprot IDs
Q9NZD8
Q9UKT9
PDB IDs
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Apoptotic Process
Protein Ubiquitination
Regulation Of Cell Death
Protein Modification By Small Protein Conjugation
Negative Regulation Of Developmental Growth
Innate Immune Response
Positive Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of Striated Muscle Tissue Development
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Positive Regulation Of Interleukin-2 Production
Positive Regulation Of Cell Death
Immune Response
Negative Regulation Of Organ Growth
Negative Regulation Of UDP-glucose Catabolic Process
Induction By Virus Of Host Cell-cell Fusion
Protein Palmitoleylation
Regulation Of Intracellular Signal Transduction
Negative Regulation Of Muscle Cell Differentiation
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of Striated Muscle Tissue Development
Regulation Of Cellular Localization
Negative Regulation Of Muscle Organ Development
Regulation Of Signal Transduction
Positive Regulation Of Apoptotic Signaling Pathway
Regulation Of Extrinsic Apoptotic Signaling Pathway
Pyrimidine Nucleotide Biosynthetic Process
Regulation Of Intracellular Transport
Negative Regulation Of Cell Differentiation
Regulation Of Protein Kinase Activity
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Negative Regulation Of Type B Pancreatic Cell Development
Negative Regulation Of SNARE Complex Assembly
Catenin Import Into Nucleus
Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition
Urate Biosynthetic Process
'de Novo' CTP Biosynthetic Process
Glycogen Metabolic Process
Regulation Of Kinase Activity
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Regulation Of Cell Differentiation
Positive Regulation Of Protein Binding
Regulation Of Skeletal Muscle Tissue Development
Regulation Of Cellular Ketone Metabolic Process
Gliogenesis
Negative Regulation Of Growth
Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process
Cell Cycle
Cell Cycle Process
Mitotic Cell Cycle Process
Organelle Organization
Gene Expression
Mitotic Cell Cycle
Negative Regulation Of Cellular Metabolic Process
Cellular Response To Stress
Cellular Response To DNA Damage Stimulus
Regulation Of Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Response To Radiation
Regulation Of Cell Cycle
Positive Regulation Of Metabolic Process
Cellular Response To Organonitrogen Compound
Response To Hormone
Nucleobase-containing Compound Metabolic Process
Cell Cycle Checkpoint
RNA Metabolic Process
Response To Ionizing Radiation
Cell Cycle Arrest
Regulation Of Signal Transduction
Insulin Receptor Signaling Pathway
Response To Organic Substance
Regulation Of Transcription From RNA Polymerase II Promoter
Heterocycle Metabolic Process
Cellular Metabolic Process
Cellular Aromatic Compound Metabolic Process
Regulation Of Mitotic Cell Cycle
Immune System Process
Response To Stress
Nitrogen Compound Metabolic Process
Signal Transduction In Response To DNA Damage
Negative Regulation Of Gene Expression
Regulation Of Nitrogen Compound Metabolic Process
Cellular Response To Hormone Stimulus
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Gene Expression
Negative Regulation Of Cell Cycle
Cellular Macromolecule Biosynthetic Process
Transcription, DNA-templated
Regulation Of Signaling
Ammonium Transmembrane Transport
Biosynthetic Process
Macromolecule Biosynthetic Process
Neurotrophin TRK Receptor Signaling Pathway
Cellular Response To Insulin Stimulus
Cellular Response To Organic Substance
Response To Organonitrogen Compound
Tagcloud
?
17q12
amplicon
cab2
ccct
darpp32
endued
gc
han
haplotype
histogenesis
immumohistochemical
implied
per1
perld1
ppp1r1b
q21
rs11869286
rs1877031
rs881844
rs9972882
sequenom
signet
stard3
steroidogenic
tcap
titin
tma
top2a
znfn1a3
Tagcloud (Difference)
?
17q12
amplicon
cab2
ccct
darpp32
endued
gc
han
haplotype
histogenesis
immumohistochemical
implied
per1
perld1
ppp1r1b
q21
rs11869286
rs1877031
rs881844
rs9972882
sequenom
signet
stard3
steroidogenic
tcap
titin
tma
top2a
znfn1a3
Tagcloud (Intersection)
?