SPG21 and PRPS1

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid, two hybrid)
HPRD (two hybrid)

		SPG21	PRPS1
Gene Name		spastic paraplegia 21 (autosomal recessive, Mast syndrome)	phosphoribosyl pyrophosphate synthetase 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Endosome Membrane Trans-Golgi Network Transport Vesicle	Cytosol
	Molecular Function	Protein Binding CD4 Receptor Binding	Magnesium Ion Binding Ribose Phosphate Diphosphokinase Activity ATP Binding Kinase Activity Protein Homodimerization Activity
	Biological Process	Antigen Receptor-mediated Signaling Pathway	Carbohydrate Metabolic Process 5-phosphoribose 1-diphosphate Biosynthetic Process Purine Nucleobase Metabolic Process Purine Nucleotide Biosynthetic Process Pyrimidine Nucleotide Biosynthetic Process Nervous System Development Ribonucleoside Monophosphate Biosynthetic Process Pathogenesis Phosphorylation Urate Biosynthetic Process Small Molecule Metabolic Process Hypoxanthine Biosynthetic Process
Pathways			5-Phosphoribose 1-diphosphate biosynthesis Myoclonic epilepsy of Lafora Glycogen storage diseases Metabolism of carbohydrates
Drugs
Diseases
GWAS
Protein-Protein Interactions		37 interactors: AGTRAP AKIRIN2 ARL6IP1 ATPAF2 CCDC102B CCDC33 CD4 CMTM5 CRYAA CTPS2 CUTC DTX2 DTX3L EFHC2 FAM114A1 GGA2 GSK3A IKZF3 INCA1 KRT15 MID2 MTMR9 PRPS1 RABAC1 REEP6 RTN4 S100B SPRED2 TCF12 TCF4 TFG TRAF1 TRAF2 TRIM23 TRIM54 TRIM9 ZNF263	5 interactors: GORASP2 PRPS2 PRPSAP1 SPG21 SUMO4
Entrez ID		51324	5631
HPRD ID		10492	02413
Ensembl ID		ENSG00000090487	ENSG00000147224
Uniprot IDs		Q9NZD8	B7ZB02 P60891
PDB IDs			2H06 2H07 2H08 2HCR 3EFH 3S5J 4F8E
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Apoptotic Process Protein Ubiquitination Regulation Of Cell Death Protein Modification By Small Protein Conjugation Negative Regulation Of Developmental Growth Innate Immune Response Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Striated Muscle Tissue Development Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Interleukin-2 Production Positive Regulation Of Cell Death Immune Response Negative Regulation Of Organ Growth Negative Regulation Of UDP-glucose Catabolic Process Induction By Virus Of Host Cell-cell Fusion Protein Palmitoleylation Regulation Of Intracellular Signal Transduction Negative Regulation Of Muscle Cell Differentiation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Striated Muscle Tissue Development Regulation Of Cellular Localization Negative Regulation Of Muscle Organ Development Regulation Of Signal Transduction Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Pyrimidine Nucleotide Biosynthetic Process Regulation Of Intracellular Transport Negative Regulation Of Cell Differentiation Regulation Of Protein Kinase Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of SNARE Complex Assembly Catenin Import Into Nucleus Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Urate Biosynthetic Process 'de Novo' CTP Biosynthetic Process Glycogen Metabolic Process Regulation Of Kinase Activity Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Cell Differentiation Positive Regulation Of Protein Binding Regulation Of Skeletal Muscle Tissue Development Regulation Of Cellular Ketone Metabolic Process Gliogenesis Negative Regulation Of Growth Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process	5-phosphoribose 1-diphosphate Biosynthetic Process AMP Biosynthetic Process Nucleotide Biosynthetic Process
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