CRYAA and TTC39B

Number of citations of the paper that reports this interaction (PubMedID 24453475)
30

Data Source:
BioGRID (pull down)

		CRYAA	TTC39B
Description		crystallin alpha A	tetratricopeptide repeat domain 39B
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	Structural Molecule Activity Structural Constituent Of Eye Lens Protein Binding Identical Protein Binding Metal Ion Binding Unfolded Protein Binding	Protein Binding
	Biological Process	Response To Hypoxia Lens Development In Camera-type Eye Lens Morphogenesis In Camera-type Eye Apoptotic Process Mitochondrion Organization Actin Filament Organization Microtubule-based Process Tubulin Complex Assembly Visual Perception Response To Heat Negative Regulation Of Gene Expression Positive Regulation Of Cell Growth Negative Regulation Of Intracellular Transport Protein Refolding Response To Hydrogen Peroxide Camera-type Eye Development Negative Regulation Of Apoptotic Process Embryonic Camera-type Eye Morphogenesis Protein Stabilization Apoptotic Process Involved In Morphogenesis Response To UV-A Lens Fiber Cell Morphogenesis	Lipid Metabolic Process Regulation Of Cholesterol Efflux Negative Regulation Of Cholesterol Storage Cholesterol Homeostasis Regulation Of Cholesterol Metabolic Process
Pathways
Drugs
Diseases
GWAS		Age-related nuclear cataracts ( 24951543 33311586) Diastolic blood pressure ( 27618452 27841878 28135244 28739976) Metabolite levels ( 23823483) Systolic blood pressure ( 27618452 27841878 28739976)	Alcoholic chronic pancreatitis ( 28754779) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Bipolar disorder ( 34099189 22925353) Bipolar disorder x sex interaction ( 34099189) Cholesterol, total ( 20686565 24097068) Coenzyme Q10 levels ( 27149984) Coronary artery disease ( 29212778) Gallstone disease ( 30504769) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol ( 19060906 25961943 20686565 20864672 30275531 24097068) HDL cholesterol levels ( 30698716 32203549 28334899) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) High density lipoprotein cholesterol levels ( 33339817) Hip circumference ( 28552196) Macular telangiectasia type 2 ( 33654266) Total cholesterol levels ( 28334899) Triglyceride levels ( 32203549) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716)
Interacting Genes		134 interacting genes: - ADPRHL1 AKT3 ALB ALDH1L2 ANKRD44 APPL2 ARFGAP1 ARMCX4 ARRDC1-AS1 ATG16L1 BCL2L1 BORA BTRC CAMKK2 CD209 CDC40 CEBPZ CENPH CER1 CNOT8 COPB2 CRTAC1 CRYAB CRYBA1 CRYBB2 CRYGC CRYGD CRYZ CS CSTF2T DCAF11 DCAF8 DCK DDX3X DUS4L E2F7 EEPD1 ETFB EYA4 FAM131B FAM131C FAM182A FASN GIGYF2 GLYATL1 GNAI2 GORASP2 GSTZ1 HABP4 HCLS1 HSPB1 HSPB2 IGHG1 IGKV1-5 JKAMP KBTBD12 KIZ KNG1 LALBA LARP6 LIMA1 MAP3K7CL MAPKBP1 MCM7 MCRS1 MINDY1 MIP MPHOSPH6 MTERF4 MYO5C NAT9 NCF4 NTAQ1 NUP43 OSBPL3 OTOGL OTULIN PABIR2 PAFAH1B1 PCYT2 PHC1 PLAUR PMS2 PRM2 PSMB6 PTPN2 PTTG2 QRICH1 RAB24 RAB29 RAB3C RAB40B RAB43 RAD51 RBBP7 RNASEH1 RNGTT RPS6KA5 SDCBP SEC24C SEH1L SESN2 SGCD SLC20A1 SLC25A25 SLC25A26 SLC25A28 SPG21 SSBP4 SULF1 SYK TASL TEAD4 TFDP1 TGOLN2 TLE4 TMEM254 TMEM52B TSR3 TTC27 TTC39B TUBAL3 TUBGCP5 UBR2 UPP1 WDR55 WDR83 WIPI2 WWC2 ZIM2 ZNF3 ZNF639 ZSCAN20	3 interacting genes: CRYAA MEOX2 VAPB
Entrez ID		1409	158219
HPRD ID		00427	10801
Ensembl ID		ENSG00000160202	ENSG00000155158
Uniprot IDs		A0A8C8KJZ9 P02489	A0A8V8N5K5 A0A8V8NCV2 A0A8V8PNE1 Q5VTQ0
PDB IDs		6T1R
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Eye Lens Lens Development In Camera-type Eye	Lens Fiber Cell Morphogenesis Somite Specification Endoplasmic Reticulum Localization FFAT Motif Binding COPII-coated Vesicle Budding Negative Regulation By Virus Of Viral Protein Levels In Host Cell Endoplasmic Reticulum-plasma Membrane Tethering Host-mediated Perturbation Of Viral RNA Genome Replication Tubulin Complex Assembly Response To UV-A Embryonic Camera-type Eye Morphogenesis Lens Morphogenesis In Camera-type Eye Segment Specification Somite Development Host-mediated Activation Of Viral Genome Replication IRE1-mediated Unfolded Protein Response Host-mediated Perturbation Of Viral Genome Replication Endoplasmic Reticulum Membrane Organization Host-mediated Suppression Of Viral Genome Replication Suppression Of Viral Release By Host Structural Constituent Of Eye Lens Embryonic Eye Morphogenesis Apoptotic Process Involved In Morphogenesis Protein Refolding Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Viral Release From Host Cell Positive Regulation Of Viral Genome Replication Endoplasmic Reticulum Exit Site Apoptotic Process Involved In Development Vesicle Budding From Membrane Protein-membrane Adaptor Activity Host-mediated Activation Of Viral Process
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