CRYAA and DCAF11

Number of citations of the paper that reports this interaction (PubMedID 24453475)
30

Data Source:
BioGRID (pull down)

		CRYAA	DCAF11
Description		crystallin alpha A	DDB1 and CUL4 associated factor 11
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex	Nucleoplasm Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	Structural Molecule Activity Structural Constituent Of Eye Lens Protein Binding Identical Protein Binding Metal Ion Binding Unfolded Protein Binding	Protein Binding
	Biological Process	Response To Hypoxia Lens Development In Camera-type Eye Lens Morphogenesis In Camera-type Eye Apoptotic Process Mitochondrion Organization Actin Filament Organization Microtubule-based Process Tubulin Complex Assembly Visual Perception Response To Heat Negative Regulation Of Gene Expression Positive Regulation Of Cell Growth Negative Regulation Of Intracellular Transport Protein Refolding Response To Hydrogen Peroxide Camera-type Eye Development Negative Regulation Of Apoptotic Process Embryonic Camera-type Eye Morphogenesis Protein Stabilization Apoptotic Process Involved In Morphogenesis Response To UV-A Lens Fiber Cell Morphogenesis	Respiratory System Process Response To Oxidative Stress Memory Gene Expression Protein Ubiquitination Exploration Behavior Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Stabilization Cognition
Pathways			Neddylation
Drugs
Diseases
GWAS		Age-related nuclear cataracts ( 24951543 33311586) Diastolic blood pressure ( 27618452 27841878 28135244 28739976) Metabolite levels ( 23823483) Systolic blood pressure ( 27618452 27841878 28739976)
Interacting Genes		134 interacting genes: - ADPRHL1 AKT3 ALB ALDH1L2 ANKRD44 APPL2 ARFGAP1 ARMCX4 ARRDC1-AS1 ATG16L1 BCL2L1 BORA BTRC CAMKK2 CD209 CDC40 CEBPZ CENPH CER1 CNOT8 COPB2 CRTAC1 CRYAB CRYBA1 CRYBB2 CRYGC CRYGD CRYZ CS CSTF2T DCAF11 DCAF8 DCK DDX3X DUS4L E2F7 EEPD1 ETFB EYA4 FAM131B FAM131C FAM182A FASN GIGYF2 GLYATL1 GNAI2 GORASP2 GSTZ1 HABP4 HCLS1 HSPB1 HSPB2 IGHG1 IGKV1-5 JKAMP KBTBD12 KIZ KNG1 LALBA LARP6 LIMA1 MAP3K7CL MAPKBP1 MCM7 MCRS1 MINDY1 MIP MPHOSPH6 MTERF4 MYO5C NAT9 NCF4 NTAQ1 NUP43 OSBPL3 OTOGL OTULIN PABIR2 PAFAH1B1 PCYT2 PHC1 PLAUR PMS2 PRM2 PSMB6 PTPN2 PTTG2 QRICH1 RAB24 RAB29 RAB3C RAB40B RAB43 RAD51 RBBP7 RNASEH1 RNGTT RPS6KA5 SDCBP SEC24C SEH1L SESN2 SGCD SLC20A1 SLC25A25 SLC25A26 SLC25A28 SPG21 SSBP4 SULF1 SYK TASL TEAD4 TFDP1 TGOLN2 TLE4 TMEM254 TMEM52B TSR3 TTC27 TTC39B TUBAL3 TUBGCP5 UBR2 UPP1 WDR55 WDR83 WIPI2 WWC2 ZIM2 ZNF3 ZNF639 ZSCAN20	15 interacting genes: AGR2 CDKN1A CRYAA CUL4B DDB1 FKBP1A GPSM1 PTEN RCN1 SLBP TNNI1 TNNI2 TNS2 TRIM55 TRIM63
Entrez ID		1409	80344
HPRD ID		00427	18297
Ensembl ID		ENSG00000160202	ENSG00000100897
Uniprot IDs		A0A8C8KJZ9 P02489	B3KSW2 Q59GN6 Q8TEB1
PDB IDs		6T1R
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Eye Lens Lens Development In Camera-type Eye	Response To UV Cul4B-RING E3 Ubiquitin Ligase Complex Troponin Complex Cellular Response To UV Cul4A-RING E3 Ubiquitin Ligase Complex UV-damage Excision Repair Spindle Assembly Involved In Female Meiosis Meiotic Spindle Assembly Cellular Response To Light Stimulus Response To Light Stimulus Regulation Of Mitotic Cell Cycle Phase Transition Meiotic Spindle Organization Protein Refolding Cul4-RING E3 Ubiquitin Ligase Complex Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Phosphate Metabolic Process Molecular Function Inhibitor Activity Regulation Of G1/S Transition Of Mitotic Cell Cycle Cellular Response To Radiation Skeletal Muscle Contraction Response To Radiation Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle G1/S Phase Transition Response To Electrical Stimulus Developmental Process Cardiac Muscle Contraction Muscle Contraction Ventricular Cardiac Muscle Tissue Morphogenesis Regulation Of Mitotic Cell Cycle Macrolide Binding Negative Regulation Of Synaptic Vesicle Clustering Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Catabolic Process Regulation Of System Process Cardiac Muscle Tissue Morphogenesis Negative Regulation Of Cell Cycle G1/S Phase Transition PCNA-p21 Complex Negative Regulation Of Cardiac Muscle Tissue Regeneration Regulation Of Growth Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Protein Modification Process Damaged DNA Binding Protein Ubiquitination Cytoplasmic Side Of Membrane Regulation Of Muscle System Process Ryanodine Receptor Complex Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?