CRYAA and LALBA

Number of citations of the paper that reports this interaction (PubMedID 9346914)
0

Data Source:
HPRD (in vitro)

		CRYAA	LALBA
Description		crystallin alpha A	lactalbumin alpha
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex	Golgi Membrane Extracellular Region Extracellular Space Golgi Lumen Protein-containing Complex
	Molecular Function	Structural Molecule Activity Structural Constituent Of Eye Lens Protein Binding Identical Protein Binding Metal Ion Binding Unfolded Protein Binding	Lysozyme Activity Lactose Synthase Activity Calcium Ion Binding Metal Ion Binding
	Biological Process	Response To Hypoxia Lens Development In Camera-type Eye Lens Morphogenesis In Camera-type Eye Apoptotic Process Mitochondrion Organization Actin Filament Organization Microtubule-based Process Tubulin Complex Assembly Visual Perception Response To Heat Negative Regulation Of Gene Expression Positive Regulation Of Cell Growth Negative Regulation Of Intracellular Transport Protein Refolding Response To Hydrogen Peroxide Camera-type Eye Development Negative Regulation Of Apoptotic Process Embryonic Camera-type Eye Morphogenesis Protein Stabilization Apoptotic Process Involved In Morphogenesis Response To UV-A Lens Fiber Cell Morphogenesis	Lactose Biosynthetic Process Apoptotic Process Signal Transduction Cell-cell Signaling Defense Response To Bacterium Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium
Pathways			Lactose synthesis Developmental Lineage of Mammary Gland Alveolar Cells
Drugs			Palmitic Acid
Diseases
GWAS		Age-related nuclear cataracts ( 24951543 33311586) Diastolic blood pressure ( 27618452 27841878 28135244 28739976) Metabolite levels ( 23823483) Systolic blood pressure ( 27618452 27841878 28739976)	Adiponectin levels ( 24105470) Itch intensity from mosquito bite adjusted by bite size ( 28199695)
Interacting Genes		134 interacting genes: - ADPRHL1 AKT3 ALB ALDH1L2 ANKRD44 APPL2 ARFGAP1 ARMCX4 ARRDC1-AS1 ATG16L1 BCL2L1 BORA BTRC CAMKK2 CD209 CDC40 CEBPZ CENPH CER1 CNOT8 COPB2 CRTAC1 CRYAB CRYBA1 CRYBB2 CRYGC CRYGD CRYZ CS CSTF2T DCAF11 DCAF8 DCK DDX3X DUS4L E2F7 EEPD1 ETFB EYA4 FAM131B FAM131C FAM182A FASN GIGYF2 GLYATL1 GNAI2 GORASP2 GSTZ1 HABP4 HCLS1 HSPB1 HSPB2 IGHG1 IGKV1-5 JKAMP KBTBD12 KIZ KNG1 LALBA LARP6 LIMA1 MAP3K7CL MAPKBP1 MCM7 MCRS1 MINDY1 MIP MPHOSPH6 MTERF4 MYO5C NAT9 NCF4 NTAQ1 NUP43 OSBPL3 OTOGL OTULIN PABIR2 PAFAH1B1 PCYT2 PHC1 PLAUR PMS2 PRM2 PSMB6 PTPN2 PTTG2 QRICH1 RAB24 RAB29 RAB3C RAB40B RAB43 RAD51 RBBP7 RNASEH1 RNGTT RPS6KA5 SDCBP SEC24C SEH1L SESN2 SGCD SLC20A1 SLC25A25 SLC25A26 SLC25A28 SPG21 SSBP4 SULF1 SYK TASL TEAD4 TFDP1 TGOLN2 TLE4 TMEM254 TMEM52B TSR3 TTC27 TTC39B TUBAL3 TUBGCP5 UBR2 UPP1 WDR55 WDR83 WIPI2 WWC2 ZIM2 ZNF3 ZNF639 ZSCAN20	6 interacting genes: B4GALT1 CRYAA CRYAB H2BC21 H3C15 HSPA8
Entrez ID		1409	3906
HPRD ID		00427	01024
Ensembl ID		ENSG00000160202	ENSG00000167531
Uniprot IDs		A0A8C8KJZ9 P02489	A0A080YV01 P00709
PDB IDs		6T1R	1A4V 1B9O 1CB3 1HML 3B0I 3B0O 4L41
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Eye Lens Lens Development In Camera-type Eye	Protein Refolding Tubulin Complex Assembly Unfolded Protein Binding Protein-containing Complex Organization Structural Constituent Of Eye Lens Apoptotic Process Involved In Morphogenesis Protein Folding Apoptotic Process Involved In Development Lens Development In Camera-type Eye Extracellular Exosome Negative Regulation Of Intracellular Transport Regulation Of Protein Stability Response To Heat Camera-type Eye Development Protein-containing Complex Assembly Positive Regulation Of Circulating Fibrinogen Levels Chaperone-mediated Autophagy Translocation Complex Disassembly Structural Constituent Of Chromatin Response To Hydrogen Peroxide Lactose Biosynthetic Process Lumenal Side Of Lysosomal Membrane Nucleosome Nucleosome Assembly Eye Development Response To Stress Negative Regulation Of Protein-containing Complex Assembly UDP-galactosyltransferase Activity Lactose Synthase Activity Regulation Of Protein Import Nucleosome Organization Response To Temperature Stimulus Response To Reactive Oxygen Species Negative Regulation Of Supramolecular Fiber Organization N-acetyllactosamine Synthase Activity Beta-N-acetylglucosaminylglycopeptide Beta-1,4-galactosyltransferase Activity Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy Sensory Organ Development Structural Molecule Activity Protein-containing Complex C3HC4-type RING Finger Domain Binding Clathrin Coat Disassembly Protein-DNA Complex Assembly Development Of Secondary Sexual Characteristics ATP-dependent Protein Disaggregase Activity Vesicle Uncoating Lens Fiber Cell Morphogenesis Cardiac Myofibril Galactosyltransferase Activity Chaperone-mediated Autophagy Protein Stabilization
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