Wiki-Pi
About
Search
People
Updates
Search
SPG21 and AGTR1
Number of citations of the paper that reports this interaction (PubMedID
28298427
)
90
Data Source:
BioGRID
(two hybrid)
SPG21
AGTR1
Description
SPG21 abhydrolase domain containing, maspardin
angiotensin II receptor type 1
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Endosome
Golgi Apparatus
Cytosol
Endosome Membrane
Membrane
Trans-Golgi Network Transport Vesicle
Plasma Membrane
Membrane
Molecular Function
Protein Binding
CD4 Receptor Binding
Angiotensin Type I Receptor Activity
G Protein-coupled Receptor Activity
Angiotensin Type II Receptor Activity
Protein Binding
Bradykinin Receptor Binding
Protein Heterodimerization Activity
Biological Process
Cell Surface Receptor Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
Locomotory Behavior
Gene Expression
Neuron Maturation
Collateral Sprouting
Antigen Receptor-mediated Signaling Pathway
Neuromuscular Process
Limb Development
Response To Epidermal Growth Factor
Regulation Of Cell Growth
Kidney Development
Renin-angiotensin Regulation Of Aldosterone Production
Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin
Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin
Inflammatory Response
Signal Transduction
G Protein-coupled Receptor Signaling Pathway
Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
Rho Protein Signal Transduction
Positive Regulation Of Macrophage Derived Foam Cell Differentiation
Regulation Of Vasoconstriction
Calcium-mediated Signaling
Low-density Lipoprotein Particle Remodeling
Regulation Of Renal Sodium Excretion
Angiotensin-activated Signaling Pathway
Regulation Of Cell Population Proliferation
Symbiont Entry Into Host Cell
Regulation Of Inflammatory Response
Positive Regulation Of Inflammatory Response
Cell Chemotaxis
Phospholipase C-activating Angiotensin-activated Signaling Pathway
Positive Regulation Of Cholesterol Metabolic Process
Blood Vessel Diameter Maintenance
Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways
Peptide ligand-binding receptors
G alpha (q) signalling events
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Drugs
Valsartan
Olmesartan
Losartan
Candesartan cilexetil
Eprosartan
Telmisartan
Irbesartan
Forasartan
Saprisartan
Tasosartan
CYT006-AngQb
Azilsartan medoxomil
Fimasartan
Angiotensin II
Candesartan
Diseases
Hereditary spastic paraplegia (SPG)
Renal tubular dysgenesis
GWAS
Birth weight (
31043758
)
Chin dimples (
27182965
)
Height (
31562340
)
Lead levels in blood (
25820613
)
Monobrow (
27182965
)
Type 2 diabetes (
31049640
)
Interacting Genes
161 interacting genes:
-
ACOT13
AGTR1
AGTRAP
AKIRIN2
APOC1
ARL6IP1
ARMC12
ARMC7
ATP5ME
BORCS6
BSND
CCDC102B
CCDC33
CCHCR1
CD4
CDK2AP1
CDKN2B
CEP76
CEPT1
CFAP410
CIDEB
CLDN22
CMTM4
CMTM5
CMTM6
COG3
COG6
CPSF7
CRX
CRYAA
CT55
CTIF
CTPS2
CUTC
DCTPP1
DRC12
DRC4
DTX3L
EFHC2
EIF1B
EIF4H
EYA2
FAM114A1
FAM86C1P
FBXO44
FLACC1
GAD2
GEMIN2
GEMIN4
GGA2
GOLGA2
GOLT1B
GRPEL1
GSK3A
HNRNPH1
HPRT1
HSD17B13
IKZF3
INCA1
IQCB1
KCTD9
KRT13
KRT15
KRT19
KRT31
LEPROTL1
LMNA
LMO1
LNX1
LSMEM2
MAB21L3
MID2
MPC2
MTMR9
MTUS2
MYG1
MYOG
N4BP3
NAB2
NDUFAF2
NIF3L1
NME4
NQO2
NR1D1
NRDE2
NUP54
PAX6
PBX4
PCBD2
PCNA
PDE5A
PEF1
PFDN5
PLP2
PNMA5
PPM1J
PRPS1
PRTFDC1
PSMB4
PTPA
RABAC1
RAD51C
REEP6
REL
ROPN1
RPRD1B
RPS19
RTL8B
RTN4
S100B
SATB1
SCAMP1
SEPTIN5
SFT2D1
SH3GL1
SLC35E3
SORBS3
SPMIP5
SPMIP6
SPRED1
SPRED2
SRGAP2B
SSBP4
SWSAP1
SYNGR1
SYNGR3
SYP
TCF12
TCF4
TEKT4
TFG
TFIP11
TLE5
TMEM208
TMEM239
TOX2
TPD52
TRAF1
TRAF2
TRIB3
TRIM14
TRIM23
TRIM50
TRIM54
TRIM9
TSGA10IP
TSNAXIP1
TTC23L
TXN
TXNL4B
UFSP1
USHBP1
VMAC
VPS25
YPEL3
ZBTB42
ZMYND12
ZNF263
ZNF581
ZNF629
77 interacting genes:
ABI3
ACE2
ADD3
AGT
AGTRAP
AP2M1
ARFGAP1
ARHGDIG
ARRB1
ARRB2
ATP13A1
ATP1B1
BAALC
BASP1
BDKRB2
BNIP3
BRD8
CBR1
CCDC25
CD37
CERS6
CUEDC2
DBNDD2
DNAJC14
DNAJC8
EGFR
FAM13B
FBXW11
FNBP1
GHITM
GNA12
GOT1
GPAA1
GPRASP1
GRK2
GRK3
GRK5
HDGFL2
HHATL
HRAS
JAK1
JAK2
JKAMP
KIAA0930
LCNL1
LLGL1
LZTS1
NACAD
NDRG2
NOS3
NPTN
NUP88
OAZ1
PCMT1
PDE6H
PLCG1
PLCH2
PNMA1
PPP1R3F
PSMD10
PTGFR
RAB5A
RAF1
RBSN
RTN3
SAE1
SCG5
SELENOF
SERINC3
SLC16A1
SPG21
THOP1
TMEM161A
TMEM80
UBR4
UGT8
YWHAQ
Entrez ID
51324
185
HPRD ID
10492
00107
Ensembl ID
ENSG00000090487
ENSG00000144891
Uniprot IDs
Q9NZD8
A0A0A0MSE3
D3DNG8
P30556
Q53YY0
Q6NUP5
PDB IDs
4YAY
4ZUD
6DO1
6OS0
6OS1
6OS2
Enriched GO Terms of Interacting Partners
?
Protein Binding
Identical Protein Binding
Motile Cilium
Structural Molecule Activity
Guanine Salvage
Purine Nucleobase Biosynthetic Process
Hypoxanthine Phosphoribosyltransferase Activity
Flagellated Sperm Motility
Sperm Motility
Cilium-dependent Cell Motility
Sperm Flagellum
Cilium Movement Involved In Cell Motility
Hypoxanthine Biosynthetic Process
Protein-containing Complex Organization
Negative Adaptation Of Signaling Pathway
Desensitization Of G Protein-coupled Receptor Signaling Pathway
Beta-adrenergic Receptor Kinase Activity
Regulation Of G Protein-coupled Receptor Signaling Pathway
Receptor Internalization
Type 1 Angiotensin Receptor Binding
G Protein-coupled Receptor Binding
G Protein-coupled Receptor Kinase Activity
Negative Regulation Of G Protein-coupled Receptor Signaling Pathway
Receptor-mediated Endocytosis
Regulation Of Cell Communication
Regulation Of Signaling
Angiotensin Receptor Binding
Endocytic Vesicle Membrane
Membrane
Type II Interferon-mediated Signaling Pathway
Regulation Of Apoptotic Process
Regulation Of Apoptotic Signaling Pathway
Regulation Of Programmed Cell Death
Regulation Of Signal Transduction
Intracellular Signaling Cassette
Regulation Of Biological Quality
Regulation Of Muscle System Process
Regulation Of Protein Modification Process
Negative Regulation Of Smooth Muscle Cell Proliferation
Regulation Of Blood Circulation
Postsynaptic Density
Negative Regulation Of Signal Transduction
Establishment Of Protein Localization
Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity
Endocytosis
Regulation Of MAPK Cascade
Regulation Of Vasoconstriction
Regulation Of Long-term Neuronal Synaptic Plasticity
Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal
Positive Regulation Of Receptor Internalization
Regulation Of The Force Of Heart Contraction By Chemical Signal
Positive Regulation Of Gap Junction Assembly
Interferon-mediated Signaling Pathway
Plasma Membrane
Clathrin-coated Pit
Protein Transport
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Regulation Of Protein Phosphorylation
Cytoplasm
ERBB Signaling Pathway
Import Into Cell
Negative Regulation Of Apoptotic Process
Tachykinin Receptor Signaling Pathway
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?