CRYAA and CRYGC

Number of citations of the paper that reports this interaction (PMID 11700327)
21

Data Source:
HPRD (in vitro)

		CRYAA	CRYGC
Gene Name		crystallin, alpha A	crystallin, gamma C
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Extracellular Vesicular Exosome	Nucleus Cytoplasm
	Molecular Function	Structural Constituent Of Eye Lens Protein Binding Identical Protein Binding Metal Ion Binding Unfolded Protein Binding	Structural Constituent Of Eye Lens Protein Binding
	Biological Process	Visual Perception Negative Regulation Of Intracellular Transport Protein Refolding Negative Regulation Of Apoptotic Process Response To Stimulus Protein Homooligomerization	Visual Perception Camera-type Eye Development
Pathways
Drugs
Diseases
GWAS			Attention deficit hyperactivity disorder ( 18839057)
Protein-Protein Interactions		17 interactors: ALB BCL2L1 CRYAB CRYBA1 CRYBB2 CRYGC CRYGD CRYZ CS GORASP2 HSPB1 HSPB2 LALBA MIP SDCBP SPG21 WDYHV1	7 interactors: CRYAA CRYAB CRYBB2 CRYGD HSPB1 HSPB2 MIP
Entrez ID		1409	1420
HPRD ID		00427	00435
Ensembl ID		ENSG00000160202	ENSG00000163254
Uniprot IDs		E9PHE4 P02489	P07315
PDB IDs			1LFE
Enriched GO Terms of Interacting Partners?		Visual Perception Sensory Perception Of Light Stimulus Camera-type Eye Development Eye Development Lens Development In Camera-type Eye Sensory Organ Development Sensory Perception Cellular Response To Gamma Radiation Neurological System Process Bile Acid And Bile Salt Transport Response To Gamma Radiation Cellular Response To Ionizing Radiation Apoptotic Process In Bone Marrow Retina Homeostasis Maintenance Of Mitochondrion Location Lactose Biosynthetic Process Response To Platinum Ion Hemolysis By Symbiont Of Host Erythrocytes Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Response To Stimulus Interaction With Host Organ Development Positive Regulation Of Extracellular Vesicular Exosome Assembly Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Suppression By Virus Of Host Apoptotic Process Anatomical Structure Development Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Cell Migration By Vascular Endothelial Growth Factor Signaling Pathway Disaccharide Metabolic Process Canalicular Bile Acid Transport Positive Regulation Of Behavior Monocarboxylic Acid Transport Response To Unfolded Protein Regulation Of Extracellular Vesicular Exosome Assembly Negative Regulation Of Cell Death Cellular Response To Radiation System Development Response To Ionizing Radiation Protein Processing Involved In Protein Targeting To Mitochondrion Response To Cycloheximide Cellular Process Regulating Host Cell Cycle In Response To Virus Mitochondrial Transport Regulation Of Intrinsic Apoptotic Signaling Pathway Tubulin Complex Assembly Positive Regulation Of Endothelial Cell Chemotaxis Negative Regulation Of Execution Phase Of Apoptosis Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Response To Stress	Visual Perception Sensory Perception Of Light Stimulus Camera-type Eye Development Lens Development In Camera-type Eye Eye Development Sensory Organ Development Sensory Perception Neurological System Process Negative Regulation Of Intracellular Transport Response To Stimulus Response To Unfolded Protein Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Response To Reactive Oxygen Species Positive Regulation Of Cell Migration By Vascular Endothelial Growth Factor Signaling Pathway Canalicular Bile Acid Transport Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Protein Processing Involved In Protein Targeting To Mitochondrion Negative Regulation Of Cell Death Tubulin Complex Assembly Protein Homooligomerization Positive Regulation Of Endothelial Cell Chemotaxis Bile Acid Secretion Glycerol Transport Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Mitochondrial Protein Processing Polyol Transport Cellular Water Homeostasis Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Tumor Necrosis Factor Biosynthetic Process Negative Regulation Of Transport Positive Regulation Of Blood Vessel Endothelial Cell Migration Apoptotic Process Involved In Morphogenesis Cellular Response To Gamma Radiation Response To Oxidative Stress Organ Development Protein Oligomerization Regulation Of Apoptotic Process Regulation Of Intracellular Transport Apoptotic Process Involved In Development Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Cell Death Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of Oxidative Stress-induced Cell Death Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Production Bile Acid And Bile Salt Transport Cell Volume Homeostasis
Tagcloud ?		aiims beaded bfsp1 cataract congenital cryab cryba1 cryba4 crybb1 crybb2 crybb3 crygs crystallin cx d85n delhi e155k e75k expands filament fourteen gja3 gja8 m1v ophthalmic sciences studio transparency y67n	coherence cryba1 cryba2 cryba4 crybb1 crybb2 crybb3 crystallin degenerative erg grafted holds intravitreal iodate lentivirally migrated millions msc mscs neurotrophin nt perception photoreceptors prosurvival retina retinal retinopathies rpe survived
Tagcloud (Difference) ?		aiims beaded bfsp1 cataract congenital cryab crygs cx d85n delhi e155k e75k expands filament fourteen gja3 gja8 m1v ophthalmic sciences studio transparency y67n	coherence cryba2 degenerative erg grafted holds intravitreal iodate lentivirally migrated millions msc mscs neurotrophin nt perception photoreceptors prosurvival retina retinal retinopathies rpe survived
Tagcloud (Intersection) ?		cryba1 cryba4 crybb1 crybb2 crybb3 crystallin