SPG21 and GEMIN4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SPG21	GEMIN4
Description		SPG21 abhydrolase domain containing, maspardin	gem nuclear organelle associated protein 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Golgi Apparatus Cytosol Endosome Membrane Membrane Trans-Golgi Network Transport Vesicle	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Cajal Body Membrane Nuclear Body Small Nuclear Ribonucleoprotein Complex SMN Complex SMN-Sm Protein Complex Extracellular Exosome Gemini Of Cajal Bodies
	Molecular Function	Protein Binding CD4 Receptor Binding	Protein Binding Ribonucleoprotein Complex Binding
	Biological Process	Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Locomotory Behavior Gene Expression Neuron Maturation Collateral Sprouting Antigen Receptor-mediated Signaling Pathway Neuromuscular Process Limb Development Response To Epidermal Growth Factor	Spliceosomal SnRNP Assembly RRNA Processing MRNA Processing RNA Splicing
Pathways			snRNP Assembly SARS-CoV-2 modulates host translation machinery
Drugs
Diseases		Hereditary spastic paraplegia (SPG)
GWAS			Prostate cancer ( 23535732)
Interacting Genes		161 interacting genes: - ACOT13 AGTR1 AGTRAP AKIRIN2 APOC1 ARL6IP1 ARMC12 ARMC7 ATP5ME BORCS6 BSND CCDC102B CCDC33 CCHCR1 CD4 CDK2AP1 CDKN2B CEP76 CEPT1 CFAP410 CIDEB CLDN22 CMTM4 CMTM5 CMTM6 COG3 COG6 CPSF7 CRX CRYAA CT55 CTIF CTPS2 CUTC DCTPP1 DRC12 DRC4 DTX3L EFHC2 EIF1B EIF4H EYA2 FAM114A1 FAM86C1P FBXO44 FLACC1 GAD2 GEMIN2 GEMIN4 GGA2 GOLGA2 GOLT1B GRPEL1 GSK3A HNRNPH1 HPRT1 HSD17B13 IKZF3 INCA1 IQCB1 KCTD9 KRT13 KRT15 KRT19 KRT31 LEPROTL1 LMNA LMO1 LNX1 LSMEM2 MAB21L3 MID2 MPC2 MTMR9 MTUS2 MYG1 MYOG N4BP3 NAB2 NDUFAF2 NIF3L1 NME4 NQO2 NR1D1 NRDE2 NUP54 PAX6 PBX4 PCBD2 PCNA PDE5A PEF1 PFDN5 PLP2 PNMA5 PPM1J PRPS1 PRTFDC1 PSMB4 PTPA RABAC1 RAD51C REEP6 REL ROPN1 RPRD1B RPS19 RTL8B RTN4 S100B SATB1 SCAMP1 SEPTIN5 SFT2D1 SH3GL1 SLC35E3 SORBS3 SPMIP5 SPMIP6 SPRED1 SPRED2 SRGAP2B SSBP4 SWSAP1 SYNGR1 SYNGR3 SYP TCF12 TCF4 TEKT4 TFG TFIP11 TLE5 TMEM208 TMEM239 TOX2 TPD52 TRAF1 TRAF2 TRIB3 TRIM14 TRIM23 TRIM50 TRIM54 TRIM9 TSGA10IP TSNAXIP1 TTC23L TXN TXNL4B UFSP1 USHBP1 VMAC VPS25 YPEL3 ZBTB42 ZMYND12 ZNF263 ZNF581 ZNF629	57 interacting genes: AGO2 ALPP CALCOCO2 CCDC185 CCT3 CDC20B CERCAM CFP DDX20 DHX9 DMPK FBXL12 FLAD1 GEMIN5 GLYR1 HR KANK2 KARS1 KRTAP13-2 KRTAP13-4 KRTAP15-1 KRTAP2-3 KRTAP2-4 KRTAP9-2 LGALS1 LGALS3 LY86 MORC4 NPPB NUFIP1 PIAS3 PSMB1 PTCD1 PTEN RAD51D RN7SL1 RNASE2 RNF10 RNU1-1 RNU2-1 S1PR4 SNRPB SNRPD1 SNRPD2 SPG21 SPRY1 SQSTM1 SRRT STXBP2 STXBP3 TAP1 TOP1 UFC1 USP15 USP2 ZNF326 ZNF35
Entrez ID		51324	50628
HPRD ID		10492	07370
Ensembl ID		ENSG00000090487	ENSG00000179409
Uniprot IDs		Q9NZD8	I3L2C7 P57678 Q8WUM5 Q9HC39
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Binding Identical Protein Binding Motile Cilium Structural Molecule Activity Guanine Salvage Purine Nucleobase Biosynthetic Process Hypoxanthine Phosphoribosyltransferase Activity Flagellated Sperm Motility Sperm Motility Cilium-dependent Cell Motility Sperm Flagellum Cilium Movement Involved In Cell Motility Hypoxanthine Biosynthetic Process Protein-containing Complex Organization	SMN-Sm Protein Complex Protein-RNA Complex Assembly Spliceosomal SnRNP Assembly U2 SnRNP 7-methylguanosine Cap Hypermethylation RNA Processing U4 SnRNP Methylosome Intermediate Filament Small Nuclear Ribonucleoprotein Complex RNA Splicing U1 SnRNP Tertiary Granule U5 SnRNP Presynaptic Dense Core Vesicle Exocytosis U2-type Prespliceosome Assembly U12-type Spliceosomal Complex MRNA Processing Perichromatin Fibrils U2-type Spliceosomal Complex RNA Polymerase II Complex Binding U2-type Catalytic Step 2 Spliceosome RNA Metabolic Process Positive Regulation Of Dendritic Cell Differentiation PICln-Sm Protein Complex Neuronal Dense Core Vesicle Exocytosis U1 SnRNP Binding Neutrophil Degranulation Transcription Elongation-coupled Chromatin Remodeling Keratin Filament RISC-loading Complex Dense Core Granule Exocytosis U4/U6 X U5 Tri-snRNP Complex RNA Binding Anaphase-promoting Complex Binding Calcium Ion-regulated Exocytosis Of Neurotransmitter RISC Complex Assembly MRNA Splicing, Via Spliceosome Spliceosomal Complex Assembly SiRNA Binding SMN Complex U2-type Precatalytic Spliceosome RNA Splicing, Via Transesterification Reactions Cytosol Locomotor Rhythm Ubiquitin Ligase Activator Activity Gemini Of Cajal Bodies Protein Binding Ribonucleoside Triphosphate Phosphatase Activity MRNA Metabolic Process
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