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CRYAA and CDC40
Number of citations of the paper that reports this interaction (PubMedID
24453475
)
30
Data Source:
BioGRID
(pull down)
CRYAA
CDC40
Description
crystallin alpha A
cell division cycle 40
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Protein-containing Complex
Nucleus
Nucleoplasm
Spliceosomal Complex
Nuclear Speck
U2-type Catalytic Step 2 Spliceosome
Catalytic Step 2 Spliceosome
Molecular Function
Structural Molecule Activity
Structural Constituent Of Eye Lens
Protein Binding
Identical Protein Binding
Metal Ion Binding
Unfolded Protein Binding
RNA Binding
MRNA Binding
Protein Binding
Biological Process
Response To Hypoxia
Lens Development In Camera-type Eye
Lens Morphogenesis In Camera-type Eye
Apoptotic Process
Mitochondrion Organization
Actin Filament Organization
Microtubule-based Process
Tubulin Complex Assembly
Visual Perception
Response To Heat
Negative Regulation Of Gene Expression
Positive Regulation Of Cell Growth
Negative Regulation Of Intracellular Transport
Protein Refolding
Response To Hydrogen Peroxide
Camera-type Eye Development
Negative Regulation Of Apoptotic Process
Embryonic Camera-type Eye Morphogenesis
Protein Stabilization
Apoptotic Process Involved In Morphogenesis
Response To UV-A
Lens Fiber Cell Morphogenesis
MRNA Splicing, Via Spliceosome
MRNA Processing
RNA Splicing
Embryonic Brain Development
Pathways
Transport of Mature mRNA derived from an Intron-Containing Transcript
mRNA Splicing - Major Pathway
mRNA 3'-end processing
RNA Polymerase II Transcription Termination
Drugs
Diseases
GWAS
Age-related nuclear cataracts (
24951543
33311586
)
Diastolic blood pressure (
27618452
27841878
28135244
28739976
)
Metabolite levels (
23823483
)
Systolic blood pressure (
27618452
27841878
28739976
)
Daytime sleep phenotypes (
27126917
)
Interacting Genes
134 interacting genes:
-
ADPRHL1
AKT3
ALB
ALDH1L2
ANKRD44
APPL2
ARFGAP1
ARMCX4
ARRDC1-AS1
ATG16L1
BCL2L1
BORA
BTRC
CAMKK2
CD209
CDC40
CEBPZ
CENPH
CER1
CNOT8
COPB2
CRTAC1
CRYAB
CRYBA1
CRYBB2
CRYGC
CRYGD
CRYZ
CS
CSTF2T
DCAF11
DCAF8
DCK
DDX3X
DUS4L
E2F7
EEPD1
ETFB
EYA4
FAM131B
FAM131C
FAM182A
FASN
GIGYF2
GLYATL1
GNAI2
GORASP2
GSTZ1
HABP4
HCLS1
HSPB1
HSPB2
IGHG1
IGKV1-5
JKAMP
KBTBD12
KIZ
KNG1
LALBA
LARP6
LIMA1
MAP3K7CL
MAPKBP1
MCM7
MCRS1
MINDY1
MIP
MPHOSPH6
MTERF4
MYO5C
NAT9
NCF4
NTAQ1
NUP43
OSBPL3
OTOGL
OTULIN
PABIR2
PAFAH1B1
PCYT2
PHC1
PLAUR
PMS2
PRM2
PSMB6
PTPN2
PTTG2
QRICH1
RAB24
RAB29
RAB3C
RAB40B
RAB43
RAD51
RBBP7
RNASEH1
RNGTT
RPS6KA5
SDCBP
SEC24C
SEH1L
SESN2
SGCD
SLC20A1
SLC25A25
SLC25A26
SLC25A28
SPG21
SSBP4
SULF1
SYK
TASL
TEAD4
TFDP1
TGOLN2
TLE4
TMEM254
TMEM52B
TSR3
TTC27
TTC39B
TUBAL3
TUBGCP5
UBR2
UPP1
WDR55
WDR83
WIPI2
WWC2
ZIM2
ZNF3
ZNF639
ZSCAN20
9 interacting genes:
CRYAA
DHX38
EPS15
MIR106B
MIRLET7A2
MIRLET7E
MIRLET7G
SMAD2
SMURF1
Entrez ID
1409
51362
HPRD ID
00427
05721
Ensembl ID
ENSG00000160202
ENSG00000168438
Uniprot IDs
A0A8C8KJZ9
P02489
O60508
PDB IDs
6T1R
5MQF
5XJC
5YZG
5Z56
5Z57
6FF4
6FF7
6ICZ
6ID0
6ID1
6QDV
6ZYM
7A5P
7AAV
7ABI
7W59
7W5A
7W5B
8C6J
8CH6
8I0T
8I0U
8I0V
8I0W
8RO2
9FMD
Enriched GO Terms of Interacting Partners
?
Structural Constituent Of Eye Lens
Lens Development In Camera-type Eye
RISC Complex
MiRNA-mediated Post-transcriptional Gene Silencing
Regulatory NcRNA-mediated Post-transcriptional Gene Silencing
Post-transcriptional Gene Silencing
Regulatory NcRNA-mediated Gene Silencing
MRNA Base-pairing Post-transcriptional Repressor Activity
Negative Regulation Of Gene Expression
Negative Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Transforming Growth Factor Beta Receptor Binding
I-SMAD Binding
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
R-SMAD Binding
Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
MiRNA-mediated Gene Silencing By MRNA Destabilization
Post-transcriptional Regulation Of Gene Expression
SMAD Binding
Negative Regulation Of Macromolecule Biosynthetic Process
Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Engulfment Of Target By Autophagosome
Negative Regulation Of Biosynthetic Process
Regulation Of Cellular Response To Growth Factor Stimulus
Homomeric SMAD Protein Complex
Negative Regulation Of Macromolecule Metabolic Process
MRNA Destabilization
Zygotic Specification Of Dorsal/ventral Axis
Activin Responsive Factor Complex
Paraxial Mesoderm Morphogenesis
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
RNA Destabilization
Regulation Of BMP Signaling Pathway
Positive Regulation Of MRNA Catabolic Process
Negative Regulation Of Metabolic Process
Response To Glucose
Embryonic Organ Morphogenesis
Regulation Of Macromolecule Metabolic Process
Response To Monosaccharide
Mesoderm Morphogenesis
Positive Regulation Of Cell Growth
Lens Fiber Cell Morphogenesis
Ubiquitin-dependent Endocytosis
Clathrin Coat Of Coated Pit
Response To Carbohydrate
Odontoblast Differentiation
SMAD Protein Complex
Pericardium Development
Trophoblast Cell Migration
3'-5' RNA Helicase Activity
Activin Receptor Binding
Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Positive Regulation Of Catabolic Process
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