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SPG21 and INCA1
Number of citations of the paper that reports this interaction (PMID
25416956
)
0
Data Source:
BioGRID
(two hybrid)
SPG21
INCA1
Gene Name
spastic paraplegia 21 (autosomal recessive, Mast syndrome)
inhibitor of CDK, cyclin A1 interacting protein 1
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Endosome Membrane
Trans-Golgi Network Transport Vesicle
Nucleus
Cytoplasm
Molecular Function
Protein Binding
CD4 Receptor Binding
Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity
Protein Binding
Cyclin Binding
Biological Process
Antigen Receptor-mediated Signaling Pathway
Negative Regulation Of Cell Proliferation
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Positive Regulation Of Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS
Obesity-related traits (
23251661
)
Protein-Protein Interactions
37 interactors:
AGTRAP
AKIRIN2
ARL6IP1
ATPAF2
CCDC102B
CCDC33
CD4
CMTM5
CRYAA
CTPS2
CUTC
DTX2
DTX3L
EFHC2
FAM114A1
GGA2
GSK3A
IKZF3
INCA1
KRT15
MID2
MTMR9
PRPS1
RABAC1
REEP6
RTN4
S100B
SPRED2
TCF12
TCF4
TFG
TRAF1
TRAF2
TRIM23
TRIM54
TRIM9
ZNF263
33 interactors:
ARMC7
CABP5
CCNA1
CDC23
CDK2
CDKN2D
CHCHD2
COL8A1
CTNNBIP1
DMRT3
EPHB6
FAM103A1
FHL2
FMR1
GRB2
HAUS1
NEK6
OSGIN1
PATE1
PTGER3
RBPMS
SAP18
SCNM1
SEC14L4
SPG21
STAMBPL1
STK16
TRIP6
UBE2D4
UBXN2B
VPS28
ZMYND19
ZNF205-AS1
Entrez ID
51324
388324
HPRD ID
10492
17150
Ensembl ID
ENSG00000090487
ENSG00000196388
Uniprot IDs
Q9NZD8
Q0VD86
PDB IDs
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Apoptotic Process
Protein Ubiquitination
Regulation Of Cell Death
Protein Modification By Small Protein Conjugation
Negative Regulation Of Developmental Growth
Innate Immune Response
Positive Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of Striated Muscle Tissue Development
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Positive Regulation Of Interleukin-2 Production
Positive Regulation Of Cell Death
Immune Response
Negative Regulation Of Organ Growth
Negative Regulation Of UDP-glucose Catabolic Process
Induction By Virus Of Host Cell-cell Fusion
Protein Palmitoleylation
Regulation Of Intracellular Signal Transduction
Negative Regulation Of Muscle Cell Differentiation
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of Striated Muscle Tissue Development
Regulation Of Cellular Localization
Negative Regulation Of Muscle Organ Development
Regulation Of Signal Transduction
Positive Regulation Of Apoptotic Signaling Pathway
Regulation Of Extrinsic Apoptotic Signaling Pathway
Pyrimidine Nucleotide Biosynthetic Process
Regulation Of Intracellular Transport
Negative Regulation Of Cell Differentiation
Regulation Of Protein Kinase Activity
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Negative Regulation Of Type B Pancreatic Cell Development
Negative Regulation Of SNARE Complex Assembly
Catenin Import Into Nucleus
Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition
Urate Biosynthetic Process
'de Novo' CTP Biosynthetic Process
Glycogen Metabolic Process
Regulation Of Kinase Activity
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Regulation Of Cell Differentiation
Positive Regulation Of Protein Binding
Regulation Of Skeletal Muscle Tissue Development
Regulation Of Cellular Ketone Metabolic Process
Gliogenesis
Negative Regulation Of Growth
Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process
Mitotic Nuclear Division
Mitotic Cell Cycle Process
Regulation Of Mitotic Cell Cycle Phase Transition
Cell Division
Regulation Of Cell Cycle Phase Transition
Mitotic Cell Cycle
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Protein K11-linked Ubiquitination
G1/S Transition Of Mitotic Cell Cycle
Cell Cycle Process
Regulation Of Metabolic Process
Regulation Of Mitotic Cell Cycle
Recruitment Of MRNA Capping Enzyme To RNA Polymerase II Holoenzyme Complex
Regulation Of Cellular Protein Metabolic Process
Regulation Of Mitotic Metaphase/anaphase Transition
Regulation Of Protein Ubiquitination
Regulation Of Cell Cycle Process
Cell Cycle Checkpoint
Regulation Of Vascular Permeability Involved In Acute Inflammatory Response
Ubiquitin-dependent Protein Catabolic Process
Regulation Of Protein Metabolic Process
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Modification-dependent Protein Catabolic Process
Nuclear Envelope Organization
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Acute Inflammatory Response
Atrial Cardiac Muscle Cell Development
Protein Targeting To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway
Cell Cycle
Regulation Of Cell Cycle
Cellular Protein Catabolic Process
Gene Expression
Spindle Assembly
RNA Processing
Positive Regulation Of DNA-dependent DNA Replication Initiation
Negative Regulation Of DNA-templated Transcription, Initiation
Negative Regulation Of Transcription Initiation From RNA Polymerase II Promoter
Fever Generation
Tagcloud
?
accompanied
arrest
bax
bcl2
birc5
ccna1
cdk2
cdkn1a
deregulation
entering
g2
lats2
microrna
mir
modification
namely
nasopharyngeal
nine
npc
phenotypes
possibly
precursor
preliminary
progression
suppressing
tp53
transfected
tw01
words
Tagcloud (Difference)
?
accompanied
arrest
bax
bcl2
birc5
ccna1
cdk2
cdkn1a
deregulation
entering
g2
lats2
microrna
mir
modification
namely
nasopharyngeal
nine
npc
phenotypes
possibly
precursor
preliminary
progression
suppressing
tp53
transfected
tw01
words
Tagcloud (Intersection)
?