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SPG21 and GGA2
Number of citations of the paper that reports this interaction (PMID
16189514
)
699
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
SPG21
GGA2
Gene Name
spastic paraplegia 21 (autosomal recessive, Mast syndrome)
golgi-associated, gamma adaptin ear containing, ARF binding protein 2
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Endosome Membrane
Trans-Golgi Network Transport Vesicle
Golgi Apparatus
Trans-Golgi Network
Endosome Membrane
Clathrin Adaptor Complex
Clathrin-coated Vesicle
Molecular Function
Protein Binding
CD4 Receptor Binding
Protein Binding
ADP-ribosylation Factor Binding
Biological Process
Antigen Receptor-mediated Signaling Pathway
Intracellular Protein Transport
Vesicle-mediated Transport
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions
37 interactors:
AGTRAP
AKIRIN2
ARL6IP1
ATPAF2
CCDC102B
CCDC33
CD4
CMTM5
CRYAA
CTPS2
CUTC
DTX2
DTX3L
EFHC2
FAM114A1
GGA2
GSK3A
IKZF3
INCA1
KRT15
MID2
MTMR9
PRPS1
RABAC1
REEP6
RTN4
S100B
SPRED2
TCF12
TCF4
TFG
TRAF1
TRAF2
TRIM23
TRIM54
TRIM9
ZNF263
30 interactors:
AFTPH
APP
ARF1
ARF3
ATXN1
BACE1
BACE2
CA8
CCDC91
CLINT1
CLTC
GGA1
GGA3
HGS
HTT
IGF2R
LRP3
M6PR
PIN1
RAB5A
RABEP1
RABGEF1
RNF11
SORL1
SORT1
SPG21
STAB1
SYNRG
TRIM23
VPS18
Entrez ID
51324
23062
HPRD ID
10492
09347
Ensembl ID
ENSG00000090487
ENSG00000103365
Uniprot IDs
Q9NZD8
Q9UJY4
PDB IDs
1MHQ
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Apoptotic Process
Protein Ubiquitination
Regulation Of Cell Death
Protein Modification By Small Protein Conjugation
Negative Regulation Of Developmental Growth
Innate Immune Response
Positive Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of Striated Muscle Tissue Development
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Positive Regulation Of Interleukin-2 Production
Positive Regulation Of Cell Death
Immune Response
Negative Regulation Of Organ Growth
Negative Regulation Of UDP-glucose Catabolic Process
Induction By Virus Of Host Cell-cell Fusion
Protein Palmitoleylation
Regulation Of Intracellular Signal Transduction
Negative Regulation Of Muscle Cell Differentiation
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of Striated Muscle Tissue Development
Regulation Of Cellular Localization
Negative Regulation Of Muscle Organ Development
Regulation Of Signal Transduction
Positive Regulation Of Apoptotic Signaling Pathway
Regulation Of Extrinsic Apoptotic Signaling Pathway
Pyrimidine Nucleotide Biosynthetic Process
Regulation Of Intracellular Transport
Negative Regulation Of Cell Differentiation
Regulation Of Protein Kinase Activity
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Negative Regulation Of Type B Pancreatic Cell Development
Negative Regulation Of SNARE Complex Assembly
Catenin Import Into Nucleus
Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition
Urate Biosynthetic Process
'de Novo' CTP Biosynthetic Process
Glycogen Metabolic Process
Regulation Of Kinase Activity
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Regulation Of Cell Differentiation
Positive Regulation Of Protein Binding
Regulation Of Skeletal Muscle Tissue Development
Regulation Of Cellular Ketone Metabolic Process
Gliogenesis
Negative Regulation Of Growth
Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process
Vesicle-mediated Transport
Endocytosis
Intracellular Transport
Protein Transport
Establishment Of Protein Localization
Transport
Establishment Of Localization In Cell
Protein Localization
Cellular Localization
Intracellular Protein Transport
Post-Golgi Vesicle-mediated Transport
Receptor-mediated Endocytosis
Lysosomal Transport
Golgi Vesicle Transport
Vacuolar Transport
Cellular Protein Localization
Endosomal Transport
Regulation Of Vesicle-mediated Transport
Endosome To Lysosome Transport
Cytoplasmic Transport
Visual Learning
Membrane Organization
Visual Behavior
Protein Targeting To Lysosome
Protein Localization To Lysosome
Associative Learning
Cellular Copper Ion Homeostasis
Membrane Protein Ectodomain Proteolysis
Signaling
Protein Targeting To Vacuole
Copper Ion Homeostasis
Cell Communication
Negative Regulation Of Signaling
Establishment Of Protein Localization To Vacuole
Learning
Transition Metal Ion Homeostasis
Membrane Protein Proteolysis
Regulation Of Exocytosis
Retrograde Vesicle-mediated Transport, Golgi To ER
Regulation Of Synaptic Plasticity
Regulation Of Protein Catabolic Process
Regulation Of Smooth Muscle Cell Migration
Negative Regulation Of Phosphorylation
Neural Plate Formation
Negative Regulation Of Kit Signaling Pathway
Positive Regulation Of Early Endosome To Recycling Endosome Transport
Negative Regulation Of Tau-protein Kinase Activity
Negative Regulation Of Aspartic-type Endopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process
Negative Regulation Of Neurofibrillary Tangle Assembly
Positive Regulation Of Choline O-acetyltransferase Activity
Tagcloud
?
addressed
adulthood
allele
attributable
byg
c57bl
c57bl6
disrupted
ear
establishes
gga1
gga3
ggas
harbors
homozygous
hypomorphic
insertional
knockout
lethality
mutagenesis
neonatal
ola129sv
placement
redundancy
ribosylation
runted
survive
tigm
true
Tagcloud (Difference)
?
addressed
adulthood
allele
attributable
byg
c57bl
c57bl6
disrupted
ear
establishes
gga1
gga3
ggas
harbors
homozygous
hypomorphic
insertional
knockout
lethality
mutagenesis
neonatal
ola129sv
placement
redundancy
ribosylation
runted
survive
tigm
true
Tagcloud (Intersection)
?