CRYAA and QRICH1

Number of citations: 30 (PubMedID 24453475)
Data Source: BioGRID (pull down)

		CRYAA	QRICH1
Name		crystallin alpha A	glutamine rich 1
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex	Nucleus Cytoplasm Plasma Membrane Membrane
	Molecular Function	Structural Molecule Activity Structural Constituent Of Eye Lens Protein Binding Identical Protein Binding Metal Ion Binding Unfolded Protein Binding	DNA Binding Protein Binding
	Biological Process	Response To Hypoxia Lens Development In Camera-type Eye Lens Morphogenesis In Camera-type Eye Apoptotic Process Mitochondrion Organization Actin Filament Organization Microtubule-based Process Tubulin Complex Assembly Visual Perception Response To Heat Negative Regulation Of Gene Expression Positive Regulation Of Cell Growth Negative Regulation Of Intracellular Transport Protein Refolding Response To Hydrogen Peroxide Camera-type Eye Development Negative Regulation Of Apoptotic Process Embryonic Camera-type Eye Morphogenesis Protein Stabilization Apoptotic Process Involved In Morphogenesis Response To UV-A Lens Fiber Cell Morphogenesis	Response To Unfolded Protein Endoplasmic Reticulum Unfolded Protein Response Response To Endoplasmic Reticulum Stress PERK-mediated Unfolded Protein Response Positive Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Integrated Stress Response Signaling
GWAS		Age-related nuclear cataracts ( 24951543 33311586 ) Diastolic blood pressure ( 27618452 27841878 28135244 28739976 ) Metabolite levels ( 23823483 ) Systolic blood pressure ( 27618452 27841878 28739976 )	Body fat distribution (leg fat ratio) ( 30664634 ) Body fat distribution (trunk fat ratio) ( 30664634 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Coronary artery disease ( 29212778 ) Cortical surface area (MOSTest) ( 32665545 ) Crohn's disease ( 28067908 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) General factor of neuroticism ( 30867560 ) Inflammatory bowel disease ( 28067908 ) Refractive error ( 32231278 ) Resting heart rate ( 27798624 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Ulcerative colitis ( 28067908 ) Waist circumference adjusted for body mass index ( 34021172 )
Novel Interactors		3 novel interactors: ERG RUNX1 SIM2	5 novel interactors: ELP6 IP6K2 KIAA1143 P4HTM TMA7
Interacting Genes		134 interacting genes: - ADPRHL1 AKT3 ALB ALDH1L2 ANKRD44 APPL2 ARFGAP1 ARMCX4 ARRDC1-AS1 ATG16L1 BCL2L1 BORA BTRC CAMKK2 CD209 CDC40 CEBPZ CENPH CER1 CNOT8 COPB2 CRTAC1 CRYAB CRYBA1 CRYBB2 CRYGC CRYGD CRYZ CS CSTF2T DCAF11 DCAF8 DCK DDX3X DUS4L E2F7 EEPD1 ETFB EYA4 FAM131B FAM131C FAM182A FASN GIGYF2 GLYATL1 GNAI2 GORASP2 GSTZ1 HABP4 HCLS1 HSPB1 HSPB2 IGHG1 IGKV1-5 JKAMP KBTBD12 KIZ KNG1 LALBA LARP6 LIMA1 MAP3K7CL MAPKBP1 MCM7 MCRS1 MINDY1 MIP MPHOSPH6 MTERF4 MYO5C NAT9 NCF4 NTAQ1 NUP43 OSBPL3 OTOGL OTULIN PABIR2 PAFAH1B1 PCYT2 PHC1 PLAUR PMS2 PRM2 PSMB6 PTPN2 PTTG2 QRICH1 RAB24 RAB29 RAB3C RAB40B RAB43 RAD51 RBBP7 RNASEH1 RNGTT RPS6KA5 SDCBP SEC24C SEH1L SESN2 SGCD SLC20A1 SLC25A25 SLC25A26 SLC25A28 SPG21 SSBP4 SULF1 SYK TASL TEAD4 TFDP1 TGOLN2 TLE4 TMEM254 TMEM52B TSR3 TTC27 TTC39B TUBAL3 TUBGCP5 UBR2 UPP1 WDR55 WDR83 WIPI2 WWC2 ZIM2 ZNF3 ZNF639 ZSCAN20	55 interacting genes: ACTL9 ACTMAP ARID5A ATF7IP ATXN1 BICRAL CEACAM6 CIMIP2B CRX CRYAA CYSRT1 DNAAF6 DSCR9 FHL2 FHL3 FHL5 GMCL1 HIVEP1 HSFY1 HSPB8 KHDC4 KLHDC7B LASP1 LBX1 LHX3 LHX4 LMO3 LMO4 MEOX1 MYH7B NFIX NFYA NLK PAX6 PIERCE2 POGZ POU6F2 PRKAR1B PUF60 RBM17 SELENOV SEPHS1 SIAH1 SMAP1 SP2 SRARP TEKT5 TOX4 TRAF1 TRAF2 USP54 YPEL3 ZDHHC17 ZMAT1 ZYX
Entrez ID		1409	54870
HPRD ID		00427	13372
Ensembl ID		ENSG00000160202	ENSG00000198218
Uniprot IDs		A0A8C8KJZ9 P02489	A1L3Z9 Q2TAL8
PDB IDs		6T1R	Not available
GO Terms Enriched among Interactors		Structural Constituent Of Eye Lens Lens Development In Camera-type Eye	Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Chromatin Medial Motor Column Neuron Differentiation Cell Differentiation In Spinal Cord Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleus Positive Regulation Of RNA Metabolic Process Motor Neuron Axon Guidance Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific Double-stranded DNA Binding Transcription Regulator Complex DNA Binding Spinal Cord Motor Neuron Cell Fate Specification DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Nucleobase-containing Compound Metabolic Process Thioesterase Binding Spinal Cord Association Neuron Differentiation HMG Box Domain Binding