CRYAA and IGHG1

Number of citations of the paper that reports this interaction (PubMedID 24453475)
30

Data Source:
BioGRID (pull down)

		CRYAA	IGHG1
Description		crystallin alpha A	immunoglobulin heavy constant gamma 1 (G1m marker)
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex	Extracellular Region Extracellular Space Plasma Membrane Membrane Immunoglobulin Complex Immunoglobulin Complex, Circulating Extracellular Exosome IgG Immunoglobulin Complex Blood Microparticle
	Molecular Function	Structural Molecule Activity Structural Constituent Of Eye Lens Protein Binding Identical Protein Binding Metal Ion Binding Unfolded Protein Binding	Antigen Binding Protein Binding Immunoglobulin Receptor Binding Fc-gamma Receptor I Complex Binding
	Biological Process	Response To Hypoxia Lens Development In Camera-type Eye Lens Morphogenesis In Camera-type Eye Apoptotic Process Mitochondrion Organization Actin Filament Organization Microtubule-based Process Tubulin Complex Assembly Visual Perception Response To Heat Negative Regulation Of Gene Expression Positive Regulation Of Cell Growth Negative Regulation Of Intracellular Transport Protein Refolding Response To Hydrogen Peroxide Camera-type Eye Development Negative Regulation Of Apoptotic Process Embryonic Camera-type Eye Morphogenesis Protein Stabilization Apoptotic Process Involved In Morphogenesis Response To UV-A Lens Fiber Cell Morphogenesis	Antibody-dependent Cellular Cytotoxicity Adaptive Immune Response Immune System Process Complement Activation, Classical Pathway Antibacterial Humoral Response B Cell Receptor Signaling Pathway Complement-dependent Cytotoxicity
Pathways
Drugs
Diseases
GWAS		Age-related nuclear cataracts ( 24951543 33311586) Diastolic blood pressure ( 27618452 27841878 28135244 28739976) Metabolite levels ( 23823483) Systolic blood pressure ( 27618452 27841878 28739976)	Composite immunoglobulin trait (IgG/IgM) ( 28628107) IgG levels ( 23225573)
Interacting Genes		134 interacting genes: - ADPRHL1 AKT3 ALB ALDH1L2 ANKRD44 APPL2 ARFGAP1 ARMCX4 ARRDC1-AS1 ATG16L1 BCL2L1 BORA BTRC CAMKK2 CD209 CDC40 CEBPZ CENPH CER1 CNOT8 COPB2 CRTAC1 CRYAB CRYBA1 CRYBB2 CRYGC CRYGD CRYZ CS CSTF2T DCAF11 DCAF8 DCK DDX3X DUS4L E2F7 EEPD1 ETFB EYA4 FAM131B FAM131C FAM182A FASN GIGYF2 GLYATL1 GNAI2 GORASP2 GSTZ1 HABP4 HCLS1 HSPB1 HSPB2 IGHG1 IGKV1-5 JKAMP KBTBD12 KIZ KNG1 LALBA LARP6 LIMA1 MAP3K7CL MAPKBP1 MCM7 MCRS1 MINDY1 MIP MPHOSPH6 MTERF4 MYO5C NAT9 NCF4 NTAQ1 NUP43 OSBPL3 OTOGL OTULIN PABIR2 PAFAH1B1 PCYT2 PHC1 PLAUR PMS2 PRM2 PSMB6 PTPN2 PTTG2 QRICH1 RAB24 RAB29 RAB3C RAB40B RAB43 RAD51 RBBP7 RNASEH1 RNGTT RPS6KA5 SDCBP SEC24C SEH1L SESN2 SGCD SLC20A1 SLC25A25 SLC25A26 SLC25A28 SPG21 SSBP4 SULF1 SYK TASL TEAD4 TFDP1 TGOLN2 TLE4 TMEM254 TMEM52B TSR3 TTC27 TTC39B TUBAL3 TUBGCP5 UBR2 UPP1 WDR55 WDR83 WIPI2 WWC2 ZIM2 ZNF3 ZNF639 ZSCAN20	9 interacting genes: CD40LG CRYAA FCGR3A FCGR3B IGKC SWAP70 TRIM21 UCHL5 USP7
Entrez ID		1409	3500
HPRD ID		00427	11755
Ensembl ID		ENSG00000160202	ENSG00000211896
Uniprot IDs		A0A8C8KJZ9 P02489
PDB IDs		6T1R
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Eye Lens Lens Development In Camera-type Eye	Immune Effector Process Immunoglobulin Mediated Immune Response B Cell Mediated Immunity IgG Receptor Activity Antibody-dependent Cellular Cytotoxicity Hypersensitivity IgG Binding Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Acute Inflammatory Response To Antigenic Stimulus Lymphocyte Mediated Immunity Regulation Of Immune System Process Leukocyte Mediated Immunity Isotype Switching Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response Regulation Of DNA-binding Transcription Factor Activity Somatic Diversification Of Immunoglobulins Involved In Immune Response Inflammatory Response Immune System Process Somatic Recombination Of Immunoglobulin Gene Segments Fc-gamma Receptor Signaling Pathway Inflammatory Response To Antigenic Stimulus Immune Response Response To Stress DNA Recombination Somatic Diversification Of Immunoglobulins Somatic Cell DNA Recombination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process DNA Metabolic Process Fc Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Adaptive Immune Response Acute Inflammatory Response Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process B Cell Activation Involved In Immune Response External Side Of Plasma Membrane Leukocyte Mediated Cytotoxicity Regulation Of Protein Stability Negative Regulation Of Proteolysis Involved In Protein Catabolic Process CD40 Receptor Binding Regulation Of Immune Response Immune Response-regulating Signaling Pathway Low-affinity IgG Receptor Activity Immune Receptor Activity Cysteine-type Deubiquitinase Activity Negative Regulation Of Cell-cell Adhesion Mediated By Integrin Autophagosome Assembly Protein Deubiquitination Positive Regulation Of Immune System Process Autophagosome Organization
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