SPG21 and -

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SPG21	-
Description		SPG21 abhydrolase domain containing, maspardin	crystallin alpha A2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Golgi Apparatus Cytosol Endosome Membrane Membrane Trans-Golgi Network Transport Vesicle
	Molecular Function	Protein Binding CD4 Receptor Binding
	Biological Process	Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Locomotory Behavior Gene Expression Neuron Maturation Collateral Sprouting Antigen Receptor-mediated Signaling Pathway Neuromuscular Process Limb Development Response To Epidermal Growth Factor
Pathways
Drugs
Diseases		Hereditary spastic paraplegia (SPG)
GWAS			HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535)
Interacting Genes		161 interacting genes: - ACOT13 AGTR1 AGTRAP AKIRIN2 APOC1 ARL6IP1 ARMC12 ARMC7 ATP5ME BORCS6 BSND CCDC102B CCDC33 CCHCR1 CD4 CDK2AP1 CDKN2B CEP76 CEPT1 CFAP410 CIDEB CLDN22 CMTM4 CMTM5 CMTM6 COG3 COG6 CPSF7 CRX CRYAA CT55 CTIF CTPS2 CUTC DCTPP1 DRC12 DRC4 DTX3L EFHC2 EIF1B EIF4H EYA2 FAM114A1 FAM86C1P FBXO44 FLACC1 GAD2 GEMIN2 GEMIN4 GGA2 GOLGA2 GOLT1B GRPEL1 GSK3A HNRNPH1 HPRT1 HSD17B13 IKZF3 INCA1 IQCB1 KCTD9 KRT13 KRT15 KRT19 KRT31 LEPROTL1 LMNA LMO1 LNX1 LSMEM2 MAB21L3 MID2 MPC2 MTMR9 MTUS2 MYG1 MYOG N4BP3 NAB2 NDUFAF2 NIF3L1 NME4 NQO2 NR1D1 NRDE2 NUP54 PAX6 PBX4 PCBD2 PCNA PDE5A PEF1 PFDN5 PLP2 PNMA5 PPM1J PRPS1 PRTFDC1 PSMB4 PTPA RABAC1 RAD51C REEP6 REL ROPN1 RPRD1B RPS19 RTL8B RTN4 S100B SATB1 SCAMP1 SEPTIN5 SFT2D1 SH3GL1 SLC35E3 SORBS3 SPMIP5 SPMIP6 SPRED1 SPRED2 SRGAP2B SSBP4 SWSAP1 SYNGR1 SYNGR3 SYP TCF12 TCF4 TEKT4 TFG TFIP11 TLE5 TMEM208 TMEM239 TOX2 TPD52 TRAF1 TRAF2 TRIB3 TRIM14 TRIM23 TRIM50 TRIM54 TRIM9 TSGA10IP TSNAXIP1 TTC23L TXN TXNL4B UFSP1 USHBP1 VMAC VPS25 YPEL3 ZBTB42 ZMYND12 ZNF263 ZNF581 ZNF629	6 interacting genes: CRYAA CRYAB GORASP2 NTAQ1 SDCBP SPG21
Entrez ID		51324	102724652
HPRD ID		10492
Ensembl ID		ENSG00000090487	ENSG00000276076
Uniprot IDs		Q9NZD8	A0A8C8KJZ9 P02489
PDB IDs			6T1R
Enriched GO Terms of Interacting Partners?		Protein Binding Identical Protein Binding Motile Cilium Structural Molecule Activity Guanine Salvage Purine Nucleobase Biosynthetic Process Hypoxanthine Phosphoribosyltransferase Activity Flagellated Sperm Motility Sperm Motility Cilium-dependent Cell Motility Sperm Flagellum Cilium Movement Involved In Cell Motility Hypoxanthine Biosynthetic Process Protein-containing Complex Organization	Tubulin Complex Assembly Structural Constituent Of Eye Lens Apoptotic Process Involved In Morphogenesis Protein Refolding Apoptotic Process Involved In Development Lens Development In Camera-type Eye Negative Regulation Of Intracellular Transport Regulation Of Cell Growth Negative Regulation Of Transport Response To Heat Camera-type Eye Development Interleukin-5 Receptor Complex Protein-N-terminal Glutamine Amidohydrolase Activity Response To Hydrogen Peroxide Unfolded Protein Binding Interleukin-5 Receptor Binding Protein-N-terminal Asparagine Amidohydrolase Activity Eye Development Regulation Of Growth Response To Temperature Stimulus Positive Regulation Of Cell Growth Response To Reactive Oxygen Species Positive Regulation Of Extracellular Exosome Assembly Syndecan Binding Sensory Organ Development Structural Molecule Activity Protein Folding Establishment Of Protein Localization To Membrane Regulation Of Extracellular Exosome Assembly Lens Fiber Cell Morphogenesis Cardiac Myofibril Protein Stabilization Positive Regulation Of Growth Actin Filament Bundle CD4 Receptor Binding Regulation Of Intracellular Transport Substrate-dependent Cell Migration, Cell Extension Response To UV-A Response To Hypoxia Response To Decreased Oxygen Levels Cellular Component Assembly Lens Morphogenesis In Camera-type Eye Negative Regulation Of Amyloid Fibril Formation Contractile Muscle Fiber Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Embryonic Camera-type Eye Morphogenesis Positive Regulation Of Exosomal Secretion Organelle Organization Response To Oxygen Levels Negative Regulation Of Receptor Internalization
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