CRYAA and SESN2

Number of citations of the paper that reports this interaction (PubMedID 24453475)
30

Data Source:
BioGRID (pull down)

		CRYAA	SESN2
Description		crystallin alpha A	sestrin 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex	Nucleus Cytoplasm Mitochondrion Lysosomal Membrane Cytosol Nucleotide-activated Protein Kinase Complex TORC2 Complex Atg1/ULK1 Kinase Complex
	Molecular Function	Structural Molecule Activity Structural Constituent Of Eye Lens Protein Binding Identical Protein Binding Metal Ion Binding Unfolded Protein Binding	Peroxidase Activity GDP-dissociation Inhibitor Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Peroxide As Acceptor Sulfiredoxin Activity PH Domain Binding Protein-containing Complex Binding L-leucine Binding Protein Sequestering Activity
	Biological Process	Response To Hypoxia Lens Development In Camera-type Eye Lens Morphogenesis In Camera-type Eye Apoptotic Process Mitochondrion Organization Actin Filament Organization Microtubule-based Process Tubulin Complex Assembly Visual Perception Response To Heat Negative Regulation Of Gene Expression Positive Regulation Of Cell Growth Negative Regulation Of Intracellular Transport Protein Refolding Response To Hydrogen Peroxide Camera-type Eye Development Negative Regulation Of Apoptotic Process Embryonic Camera-type Eye Morphogenesis Protein Stabilization Apoptotic Process Involved In Morphogenesis Response To UV-A Lens Fiber Cell Morphogenesis	Regulation Of Protein Phosphorylation Regulation Of Gluconeogenesis Fatty Acid Beta-oxidation Mitochondrion Organization Response To Glucose Positive Regulation Of Macroautophagy Negative Regulation Of Cell Growth DNA Damage Response, Signal Transduction By P53 Class Mediator Cellular Response To Nutrient Levels Mitochondrial DNA Metabolic Process Response To Insulin Cellular Response To Amino Acid Starvation Cellular Response To Oxidative Stress Cellular Response To Glucose Starvation Glucose Homeostasis D-glucose Import Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Triglyceride Homeostasis Protein K63-linked Ubiquitination Cellular Response To Amino Acid Stimulus Cellular Response To L-leucine Reactive Oxygen Species Metabolic Process Protein K6-linked Ubiquitination Cellular Oxidant Detoxification Regulation Of CAMP/PKA Signal Transduction Positive Regulation Of Protein Localization To Nucleus Regulation Of Response To Reactive Oxygen Species Negative Regulation Of Translation In Response To Endoplasmic Reticulum Stress Regulation Of TORC1 Signaling Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Positive Regulation Of Lipophagy Cellular Response To Leucine Starvation
Pathways			TP53 Regulates Metabolic Genes Amino acids regulate mTORC1 KEAP1-NFE2L2 pathway
Drugs
Diseases
GWAS		Age-related nuclear cataracts ( 24951543 33311586) Diastolic blood pressure ( 27618452 27841878 28135244 28739976) Metabolite levels ( 23823483) Systolic blood pressure ( 27618452 27841878 28739976)	Aspartate aminotransferase levels ( 33547301) Serum uric acid levels ( 30993211) Urate levels ( 31578528)
Interacting Genes		134 interacting genes: - ADPRHL1 AKT3 ALB ALDH1L2 ANKRD44 APPL2 ARFGAP1 ARMCX4 ARRDC1-AS1 ATG16L1 BCL2L1 BORA BTRC CAMKK2 CD209 CDC40 CEBPZ CENPH CER1 CNOT8 COPB2 CRTAC1 CRYAB CRYBA1 CRYBB2 CRYGC CRYGD CRYZ CS CSTF2T DCAF11 DCAF8 DCK DDX3X DUS4L E2F7 EEPD1 ETFB EYA4 FAM131B FAM131C FAM182A FASN GIGYF2 GLYATL1 GNAI2 GORASP2 GSTZ1 HABP4 HCLS1 HSPB1 HSPB2 IGHG1 IGKV1-5 JKAMP KBTBD12 KIZ KNG1 LALBA LARP6 LIMA1 MAP3K7CL MAPKBP1 MCM7 MCRS1 MINDY1 MIP MPHOSPH6 MTERF4 MYO5C NAT9 NCF4 NTAQ1 NUP43 OSBPL3 OTOGL OTULIN PABIR2 PAFAH1B1 PCYT2 PHC1 PLAUR PMS2 PRM2 PSMB6 PTPN2 PTTG2 QRICH1 RAB24 RAB29 RAB3C RAB40B RAB43 RAD51 RBBP7 RNASEH1 RNGTT RPS6KA5 SDCBP SEC24C SEH1L SESN2 SGCD SLC20A1 SLC25A25 SLC25A26 SLC25A28 SPG21 SSBP4 SULF1 SYK TASL TEAD4 TFDP1 TGOLN2 TLE4 TMEM254 TMEM52B TSR3 TTC27 TTC39B TUBAL3 TUBGCP5 UBR2 UPP1 WDR55 WDR83 WIPI2 WWC2 ZIM2 ZNF3 ZNF639 ZSCAN20	6 interacting genes: CRYAA MDM2 PRDX1 RNF167 RNF186 STAMBPL1
Entrez ID		1409	83667
HPRD ID		00427	06378
Ensembl ID		ENSG00000160202	ENSG00000130766
Uniprot IDs		A0A8C8KJZ9 P02489	P58004
PDB IDs		6T1R	5CUF 5DJ4 5T0N 6N0M
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Eye Lens Lens Development In Camera-type Eye	Protein Polyubiquitination Cellular Response To Leucine Starvation Protein K29-linked Ubiquitination Response To Reactive Oxygen Species Protein Ubiquitination Response To Stress Protein Modification By Small Protein Conjugation Protein K6-linked Ubiquitination Cellular Response To Nutrient Levels Ubiquitin-protein Transferase Activity Post-translational Protein Modification Response To Oxidative Stress Ubiquitin Protein Ligase Activity Cellular Response To Amino Acid Starvation Response To Amino Acid Starvation Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Protein Autoubiquitination Protein K63-linked Ubiquitination Proteolysis Response To Formaldehyde Cellular Response To Vitamin B1 Positive Regulation Of TOR Signaling Response To Nutrient Levels Negative Regulation Of TOR Signaling Regulation Of TORC1 Signaling Response To Hydrogen Peroxide Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Apoptotic Process In Response To Mitochondrial Fragmentation Cellular Response To Stress Protein Modification Process Response To Vitamin B1 Response To Water-immersion Restraint Stress Cellular Response To Actinomycin D Proteolysis Involved In Protein Catabolic Process Regulation Of TOR Signaling Response To UV NEDD8 Ligase Activity Response To Actinomycin D Traversing Start Control Point Of Mitotic Cell Cycle Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Negative Regulation Of Intracellular Signal Transduction Cellular Response To UV-C Thioredoxin-dependent Peroxiredoxin Activity Cellular Response To Starvation Metal Ion Binding Receptor Serine/threonine Kinase Binding Catabolic Process Peroxiredoxin Activity
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