SPG21 and MYOG

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SPG21	MYOG
Description		SPG21 abhydrolase domain containing, maspardin	myogenin
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Golgi Apparatus Cytosol Endosome Membrane Membrane Trans-Golgi Network Transport Vesicle	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Protein-DNA Complex
	Molecular Function	Protein Binding CD4 Receptor Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Chromatin DNA Binding Sequence-specific DNA Binding Protein Dimerization Activity E-box Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Locomotory Behavior Gene Expression Neuron Maturation Collateral Sprouting Antigen Receptor-mediated Signaling Pathway Neuromuscular Process Limb Development Response To Epidermal Growth Factor	Ossification Regulation Of DNA-templated Transcription Muscle Organ Development Skeletal Muscle Tissue Development Negative Regulation Of Cell Population Proliferation Tissue Development Positive Regulation Of Myotube Differentiation Positive Regulation Of Muscle Atrophy Regulation Of Skeletal Muscle Satellite Cell Proliferation Response To Muscle Activity Involved In Regulation Of Muscle Adaptation Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Striated Muscle Atrophy Response To Denervation Involved In Regulation Of Muscle Adaptation Myotube Differentiation Cell Differentiation Skeletal Muscle Cell Differentiation Muscle Cell Differentiation Muscle Cell Fate Commitment Positive Regulation Of Myoblast Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Animal Organ Development Skeletal Muscle Fiber Development Positive Regulation Of Skeletal Muscle Fiber Development Regulation Of Cell Cycle Cellular Response To Lithium Ion Cellular Response To Tumor Necrosis Factor Cellular Response To Growth Factor Stimulus Cellular Response To Estradiol Stimulus Regulation Of Myoblast Fusion
Pathways			Myogenesis Myogenesis TGFBR3 expression
Drugs
Diseases		Hereditary spastic paraplegia (SPG)
GWAS			Asthma ( 30929738 31959851) Asthma (childhood onset) ( 30929738)
Interacting Genes		161 interacting genes: - ACOT13 AGTR1 AGTRAP AKIRIN2 APOC1 ARL6IP1 ARMC12 ARMC7 ATP5ME BORCS6 BSND CCDC102B CCDC33 CCHCR1 CD4 CDK2AP1 CDKN2B CEP76 CEPT1 CFAP410 CIDEB CLDN22 CMTM4 CMTM5 CMTM6 COG3 COG6 CPSF7 CRX CRYAA CT55 CTIF CTPS2 CUTC DCTPP1 DRC12 DRC4 DTX3L EFHC2 EIF1B EIF4H EYA2 FAM114A1 FAM86C1P FBXO44 FLACC1 GAD2 GEMIN2 GEMIN4 GGA2 GOLGA2 GOLT1B GRPEL1 GSK3A HNRNPH1 HPRT1 HSD17B13 IKZF3 INCA1 IQCB1 KCTD9 KRT13 KRT15 KRT19 KRT31 LEPROTL1 LMNA LMO1 LNX1 LSMEM2 MAB21L3 MID2 MPC2 MTMR9 MTUS2 MYG1 MYOG N4BP3 NAB2 NDUFAF2 NIF3L1 NME4 NQO2 NR1D1 NRDE2 NUP54 PAX6 PBX4 PCBD2 PCNA PDE5A PEF1 PFDN5 PLP2 PNMA5 PPM1J PRPS1 PRTFDC1 PSMB4 PTPA RABAC1 RAD51C REEP6 REL ROPN1 RPRD1B RPS19 RTL8B RTN4 S100B SATB1 SCAMP1 SEPTIN5 SFT2D1 SH3GL1 SLC35E3 SORBS3 SPMIP5 SPMIP6 SPRED1 SPRED2 SRGAP2B SSBP4 SWSAP1 SYNGR1 SYNGR3 SYP TCF12 TCF4 TEKT4 TFG TFIP11 TLE5 TMEM208 TMEM239 TOX2 TPD52 TRAF1 TRAF2 TRIB3 TRIM14 TRIM23 TRIM50 TRIM54 TRIM9 TSGA10IP TSNAXIP1 TTC23L TXN TXNL4B UFSP1 USHBP1 VMAC VPS25 YPEL3 ZBTB42 ZMYND12 ZNF263 ZNF581 ZNF629	62 interacting genes: ABI2 BBS4 BFSP2 BHLHA15 CALM1 CALM2 CALM3 CARM1 CCDC120 CCDC28A CDH18 CFAP53 CFTR CLUAP1 CPSF4 CSRP3 CTNNA3 EIF4E2 FAM110A FAM90A1 FBXO32 FBXO7 FIGLA FTL GEM H2AP HNF1A ID1 ID2 ID3 IKBIP IL16 KLHL42 LAMTOR5 LMO3 MAPK3 MAPKBP1 MBD3 MDFI MEF2A MEF2C MLH1 NEK6 ODAD4 PACRGL POLR2C POLR2J PRMT5 SEPTIN5 SP1 SPG21 SRF TAF6L TCF3 TLE5 TRIM43 TSSK3 TTC32 TXNDC9 USHBP1 YME1L1 ZCCHC14
Entrez ID		51324	4656
HPRD ID		10492	01167
Ensembl ID		ENSG00000090487	ENSG00000122180
Uniprot IDs		Q9NZD8	P15173
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Binding Identical Protein Binding Motile Cilium Structural Molecule Activity Guanine Salvage Purine Nucleobase Biosynthetic Process Hypoxanthine Phosphoribosyltransferase Activity Flagellated Sperm Motility Sperm Motility Cilium-dependent Cell Motility Sperm Flagellum Cilium Movement Involved In Cell Motility Hypoxanthine Biosynthetic Process Protein-containing Complex Organization	Protein Dimerization Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity DNA-binding Transcription Factor Binding Cytoskeleton Transporter Inhibitor Activity Regulation Of Calcium Ion Export Across Plasma Membrane Spindle Pole Protein-containing Complex BHLH Transcription Factor Binding Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Heart Development Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Negative Regulation Of High Voltage-gated Calcium Channel Activity Titin Binding Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Transcription Regulator Inhibitor Activity Spindle Microtubule Nucleus Detection Of Calcium Ion Cardiac Myofibril Assembly Regulation Of Cell Communication By Electrical Coupling Calcium Channel Regulator Activity Protein Phosphatase Activator Activity Protein Heterodimerization Activity Histone Arginine N-methyltransferase Activity Calyx Of Held Sarcomere E-box Binding Positive Regulation Of Macromolecule Biosynthetic Process Face Development Catalytic Complex Heart Looping Regulation Of Developmental Process Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Heart Contraction Developmental Process Embryonic Heart Tube Morphogenesis Negative Regulation Of Transporter Activity Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Calcium Channel Complex Calcineurin-mediated Signaling Positive Regulation Of Biosynthetic Process Lung Morphogenesis Regulation Of B Cell Activation Presynaptic Cytosol Regulation Of Cardiac Muscle Cell Action Potential Response To Calcium Ion Myelin Sheath
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