CRYAA and ALB

Number of citations of the paper that reports this interaction (PubMedID 9618718)
0

Data Source:
HPRD (in vitro)

		CRYAA	ALB
Description		crystallin alpha A	albumin
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex	Extracellular Region Extracellular Space Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Apparatus Platelet Alpha Granule Lumen Protein-containing Complex Extracellular Exosome Blood Microparticle
	Molecular Function	Structural Molecule Activity Structural Constituent Of Eye Lens Protein Binding Identical Protein Binding Metal Ion Binding Unfolded Protein Binding	DNA Binding Fatty Acid Binding Copper Ion Binding Protein Binding Lipid Binding Toxic Substance Binding Antioxidant Activity Oxygen Binding Pyridoxal Phosphate Binding Identical Protein Binding Metal Ion Binding Protein-folding Chaperone Binding Exogenous Protein Binding Enterobactin Binding
	Biological Process	Response To Hypoxia Lens Development In Camera-type Eye Lens Morphogenesis In Camera-type Eye Apoptotic Process Mitochondrion Organization Actin Filament Organization Microtubule-based Process Tubulin Complex Assembly Visual Perception Response To Heat Negative Regulation Of Gene Expression Positive Regulation Of Cell Growth Negative Regulation Of Intracellular Transport Protein Refolding Response To Hydrogen Peroxide Camera-type Eye Development Negative Regulation Of Apoptotic Process Embryonic Camera-type Eye Morphogenesis Protein Stabilization Apoptotic Process Involved In Morphogenesis Response To UV-A Lens Fiber Cell Morphogenesis	Cellular Response To Starvation Response To Nutrient Levels Negative Regulation Of Mitochondrial Depolarization Cellular Response To Calcium Ion Starvation Cellular Oxidant Detoxification
Pathways			Platelet degranulation Recycling of bile acids and salts Heme biosynthesis Heme degradation Scavenging of heme from plasma Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation HDL remodeling Cytoprotection by HMOX1 Aspirin ADME Prednisone ADME Ciprofloxacin ADME
Drugs			Amsacrine Cefotaxime Phenol Norelgestromin Aniline Guaiacol Artenimol Silver Patent Blue
Diseases
GWAS		Age-related nuclear cataracts ( 24951543 33311586) Diastolic blood pressure ( 27618452 27841878 28135244 28739976) Metabolite levels ( 23823483) Systolic blood pressure ( 27618452 27841878 28739976)	Cholesterol ester levels in large LDL ( 29084231) Cholesterol ester levels in medium LDL ( 29084231) Esterified cholesterol levels ( 29084231) Free cholesterol levels ( 29084231) Free cholesterol levels in large LDL ( 29084231) Large LDL particle concentration ( 29084231) Lipid metabolism phenotypes ( 22286219) Medium LDL particle concentration ( 29084231) Prostate cancer ( 23535732) Serum total cholesterol levels ( 29084231) Small LDL particle concentration ( 29084231) Total cholesterol levels in large LDL ( 29084231) Total cholesterol levels in LDL ( 29084231) Total cholesterol levels in medium LDL ( 29084231) Total cholesterol levels in small LDL ( 29084231)
Interacting Genes		134 interacting genes: - ADPRHL1 AKT3 ALB ALDH1L2 ANKRD44 APPL2 ARFGAP1 ARMCX4 ARRDC1-AS1 ATG16L1 BCL2L1 BORA BTRC CAMKK2 CD209 CDC40 CEBPZ CENPH CER1 CNOT8 COPB2 CRTAC1 CRYAB CRYBA1 CRYBB2 CRYGC CRYGD CRYZ CS CSTF2T DCAF11 DCAF8 DCK DDX3X DUS4L E2F7 EEPD1 ETFB EYA4 FAM131B FAM131C FAM182A FASN GIGYF2 GLYATL1 GNAI2 GORASP2 GSTZ1 HABP4 HCLS1 HSPB1 HSPB2 IGHG1 IGKV1-5 JKAMP KBTBD12 KIZ KNG1 LALBA LARP6 LIMA1 MAP3K7CL MAPKBP1 MCM7 MCRS1 MINDY1 MIP MPHOSPH6 MTERF4 MYO5C NAT9 NCF4 NTAQ1 NUP43 OSBPL3 OTOGL OTULIN PABIR2 PAFAH1B1 PCYT2 PHC1 PLAUR PMS2 PRM2 PSMB6 PTPN2 PTTG2 QRICH1 RAB24 RAB29 RAB3C RAB40B RAB43 RAD51 RBBP7 RNASEH1 RNGTT RPS6KA5 SDCBP SEC24C SEH1L SESN2 SGCD SLC20A1 SLC25A25 SLC25A26 SLC25A28 SPG21 SSBP4 SULF1 SYK TASL TEAD4 TFDP1 TGOLN2 TLE4 TMEM254 TMEM52B TSR3 TTC27 TTC39B TUBAL3 TUBGCP5 UBR2 UPP1 WDR55 WDR83 WIPI2 WWC2 ZIM2 ZNF3 ZNF639 ZSCAN20	32 interacting genes: AGA AMBP APOE CRYAA CUBN F7 FCGRT FNDC3B FOXP1 HNF1A IMMT KLK3 LAMTOR5 LINC00624 LINC02582 LRP2 LUC7L2 NR5A2 ORM1 PFDN1 PON1 PRB3 RBP4 RNF181 RYR2 SRGN ST13 TK1 USP7 VWF WEE2-AS1 YWHAG
Entrez ID		1409	213
HPRD ID		00427	00062
Ensembl ID		ENSG00000160202	ENSG00000163631
Uniprot IDs		A0A8C8KJZ9 P02489	P02768
PDB IDs		6T1R	1AO6 1BJ5 1BKE 1BM0 1E78 1E7A 1E7B 1E7C 1E7E 1E7F 1E7G 1E7H 1E7I 1GNI 1GNJ 1H9Z 1HA2 1HK1 1HK2 1HK3 1HK4 1HK5 1N5U 1O9X 1TF0 1UOR 1YSX 2BX8 2BXA 2BXB 2BXC 2BXD 2BXE 2BXF 2BXG 2BXH 2BXI 2BXK 2BXL 2BXM 2BXN 2BXO 2BXP 2BXQ 2ESG 2I2Z 2I30 2N0X 2VDB 2VUE 2VUF 2XSI 2XVQ 2XVU 2XVV 2XVW 2XW0 2XW1 2YDF 3A73 3B9L 3B9M 3CX9 3JQZ 3JRY 3LU6 3LU7 3LU8 3SQJ 3TDL 3UIV 4BKE 4E99 4EMX 4G03 4G04 4HGK 4HGM 4IW1 4IW2 4K2C 4K71 4L8U 4L9K 4L9Q 4LA0 4LB2 4LB9 4N0F 4N0U 4S1Y 4Z69 5FUO 5GIX 5GIY 5ID7 5IFO 5IJF 5UJB 5VNW 5X52 5YB1 5YOQ 5Z0B 6A7P 6EZQ 6JE7 6L4K 6M4R 6M58 6M5D 6M5E 6QIO 6QIP 6R7S 6WUW 6XV0 6YG9 6ZL1 7A9C 7AAE 7AAI 7D6J 7DJN 7DL4 7EEK 7FFR 7FFS 7JWN 7QFE 7VR0 7VR9 7WKZ 7WLF 7WOJ 7WOK 7WZ9 7X7X 7Y2D 7Z57 8A9Q 8CKS 8EW4 8EW7 8EY5 8H0O 8ISM 8ITR 8ITT 8J8E 8K1Y 8OI2 8Q3F 8RCO 8RCP 8RGK 8RGL 8VAC 8VAE 8VAF 8Y9S 8Y9T 8Y9U 8YG7 8YXA 8YXB 8Z8V 9CSG
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Eye Lens Lens Development In Camera-type Eye	Steroid Metabolic Process Protein-containing Complex Vascular Endothelial Growth Factor Binding Extracellular Space Blood Microparticle Negative Regulation Of Multicellular Organismal Process Vascular Endothelial Growth Factor Receptor Activity Genitalia Development Vitamin Transport Cobalamin Transport Vagina Development Alcohol Metabolic Process Regulation Of Biological Quality Regulation Of Multicellular Organismal Process Regulation Of TOR Signaling Response To Reactive Oxygen Species Platelet Alpha Granule Lumen TORC1 Signaling Negative Regulation Of Amyloid Fibril Formation Regulation Of Blood Coagulation Regulation Of Hemostasis Extracellular Region Regulation Of Defense Response To Bacterium Female Genitalia Development Vitamin Transmembrane Transport Regulation Of Amyloid Fibril Formation Negative Regulation Of Platelet Activation Transcytosis Receptor Complex Vascular Endothelial Growth Factor Signaling Pathway TOR Signaling U1 SnRNP Positive Regulation Of TOR Signaling Cytochrome C Metabolic Process Antioxidant Activity Extracellular Matrix Extracellular Exosome Negative Regulation Of Phospholipid Efflux Sterol Metabolic Process Chemical Homeostasis Negative Regulation Of Gene Expression High-density Lipoprotein Particle Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipid Transport Across Blood-brain Barrier Cholesterol Metabolic Process Negative Regulation Of Lipid Transport Across Blood-brain Barrier Regulation Of Cellular Response To Very-low-density Lipoprotein Particle Stimulus Positive Regulation Of Multicellular Organismal Process Calcium Ion Homeostasis Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway
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