SPG21 and TFG

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		SPG21	TFG
Gene Name		spastic paraplegia 21 (autosomal recessive, Mast syndrome)	TRK-fused gene
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Endosome Membrane Trans-Golgi Network Transport Vesicle	Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Protein Binding CD4 Receptor Binding	Signal Transducer Activity Protein Binding Identical Protein Binding
	Biological Process	Antigen Receptor-mediated Signaling Pathway	Signal Transduction Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		37 interactors: AGTRAP AKIRIN2 ARL6IP1 ATPAF2 CCDC102B CCDC33 CD4 CMTM5 CRYAA CTPS2 CUTC DTX2 DTX3L EFHC2 FAM114A1 GGA2 GSK3A IKZF3 INCA1 KRT15 MID2 MTMR9 PRPS1 RABAC1 REEP6 RTN4 S100B SPRED2 TCF12 TCF4 TFG TRAF1 TRAF2 TRIM23 TRIM54 TRIM9 ZNF263	30 interactors: ANXA11 ARHGEF16 ARL15 BOLL C14orf1 CEP55 CRMP1 CSTF2 EWSR1 GBP2 GPRASP1 GRB2 HNRNPF KIAA1377 MAGED1 MAPK1IP1L MED21 MYOT PEF1 PIN1 PLSCR1 PTPN6 RBPMS RIPPLY2 SEC24A SPG21 STAT5B TRIM25 TSSK2 VPS37C
Entrez ID		51324	10342
HPRD ID		10492	03932
Ensembl ID		ENSG00000090487	ENSG00000114354
Uniprot IDs		Q9NZD8	Q05BK6 Q92734
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Apoptotic Process Protein Ubiquitination Regulation Of Cell Death Protein Modification By Small Protein Conjugation Negative Regulation Of Developmental Growth Innate Immune Response Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Striated Muscle Tissue Development Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Interleukin-2 Production Positive Regulation Of Cell Death Immune Response Negative Regulation Of Organ Growth Negative Regulation Of UDP-glucose Catabolic Process Induction By Virus Of Host Cell-cell Fusion Protein Palmitoleylation Regulation Of Intracellular Signal Transduction Negative Regulation Of Muscle Cell Differentiation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Striated Muscle Tissue Development Regulation Of Cellular Localization Negative Regulation Of Muscle Organ Development Regulation Of Signal Transduction Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Pyrimidine Nucleotide Biosynthetic Process Regulation Of Intracellular Transport Negative Regulation Of Cell Differentiation Regulation Of Protein Kinase Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of SNARE Complex Assembly Catenin Import Into Nucleus Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Urate Biosynthetic Process 'de Novo' CTP Biosynthetic Process Glycogen Metabolic Process Regulation Of Kinase Activity Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Cell Differentiation Positive Regulation Of Protein Binding Regulation Of Skeletal Muscle Tissue Development Regulation Of Cellular Ketone Metabolic Process Gliogenesis Negative Regulation Of Growth Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process	Response To Cytokine Cytokine-mediated Signaling Pathway Cell Separation After Cytokinesis Response To Interferon-beta JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Growth Hormone Receptor Signaling Pathway Interferon-gamma-mediated Signaling Pathway Cellular Response To Growth Hormone Stimulus Cellular Response To Cytokine Stimulus Regulation Of B Cell Differentiation Immune System Process Cellular Response To Interferon-gamma Defense Response Positive Regulation Of Immune Response Acute-phase Response Response To Growth Hormone Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Interferon-gamma Cellular Response To Organic Substance Mitotic Cytokinesis Negative Regulation Of Type I Interferon Production Platelet Activation JAK-STAT Cascade Positive Regulation Of T Cell Activation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Response To Organic Substance Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Cell Activation Neurotrophin Signaling Pathway Innate Immune Response Cell Surface Receptor Signaling Pathway Abortive Mitotic Cell Cycle G-protein Coupled Receptor Catabolic Process Positive Regulation Of Cell-cell Adhesion Regulation Of Innate Immune Response Regulation Of Immune Response Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Cytokinesis, Completion Of Separation Acute Inflammatory Response Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Signal Transduction Negative Regulation Of Viral Process Positive Regulation Of Immune System Process T Cell Costimulation Receptor Metabolic Process Cell Cycle Immune Response-activating Cell Surface Receptor Signaling Pathway Response To External Stimulus Regulation Of Body Fluid Levels
Tagcloud ?			architecture associate cargo carriers coat coated compartments concentrate copii cup en ergic exit export flexible interface interorganellar laden leave neighboring octameric polymers route slows submicron tight traverse trk uncoating
Tagcloud (Difference) ?			architecture associate cargo carriers coat coated compartments concentrate copii cup en ergic exit export flexible interface interorganellar laden leave neighboring octameric polymers route slows submicron tight traverse trk uncoating
Tagcloud (Intersection) ?