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SPG21 and DTX3L
Number of citations of the paper that reports this interaction (PMID
25416956
)
0
Data Source:
BioGRID
(two hybrid)
SPG21
DTX3L
Gene Name
spastic paraplegia 21 (autosomal recessive, Mast syndrome)
deltex 3 like, E3 ubiquitin ligase
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Endosome Membrane
Trans-Golgi Network Transport Vesicle
Nucleus
Nucleoplasm
Cytoplasm
Molecular Function
Protein Binding
CD4 Receptor Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Ligase Activity
Histone Binding
Biological Process
Antigen Receptor-mediated Signaling Pathway
Double-strand Break Repair
Cellular Response To DNA Damage Stimulus
Histone Monoubiquitination
Pathways
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Adaptive Immune System
Drugs
Diseases
GWAS
Major depressive disorder (
22472876
)
Protein-Protein Interactions
37 interactors:
AGTRAP
AKIRIN2
ARL6IP1
ATPAF2
CCDC102B
CCDC33
CD4
CMTM5
CRYAA
CTPS2
CUTC
DTX2
DTX3L
EFHC2
FAM114A1
GGA2
GSK3A
IKZF3
INCA1
KRT15
MID2
MTMR9
PRPS1
RABAC1
REEP6
RTN4
S100B
SPRED2
TCF12
TCF4
TFG
TRAF1
TRAF2
TRIM23
TRIM54
TRIM9
ZNF263
19 interactors:
DTX1
ITCH
PARP9
PHF7
RNF111
SPG21
TRIM9
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2H
UBE2I
UBE2K
UBE2R2
UBE2W
Entrez ID
51324
151636
HPRD ID
10492
16843
Ensembl ID
ENSG00000090487
ENSG00000163840
Uniprot IDs
Q9NZD8
Q8TDB6
PDB IDs
3PG6
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Apoptotic Process
Protein Ubiquitination
Regulation Of Cell Death
Protein Modification By Small Protein Conjugation
Negative Regulation Of Developmental Growth
Innate Immune Response
Positive Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of Striated Muscle Tissue Development
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Positive Regulation Of Interleukin-2 Production
Positive Regulation Of Cell Death
Immune Response
Negative Regulation Of Organ Growth
Negative Regulation Of UDP-glucose Catabolic Process
Induction By Virus Of Host Cell-cell Fusion
Protein Palmitoleylation
Regulation Of Intracellular Signal Transduction
Negative Regulation Of Muscle Cell Differentiation
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of Striated Muscle Tissue Development
Regulation Of Cellular Localization
Negative Regulation Of Muscle Organ Development
Regulation Of Signal Transduction
Positive Regulation Of Apoptotic Signaling Pathway
Regulation Of Extrinsic Apoptotic Signaling Pathway
Pyrimidine Nucleotide Biosynthetic Process
Regulation Of Intracellular Transport
Negative Regulation Of Cell Differentiation
Regulation Of Protein Kinase Activity
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Negative Regulation Of Type B Pancreatic Cell Development
Negative Regulation Of SNARE Complex Assembly
Catenin Import Into Nucleus
Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition
Urate Biosynthetic Process
'de Novo' CTP Biosynthetic Process
Glycogen Metabolic Process
Regulation Of Kinase Activity
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Regulation Of Cell Differentiation
Positive Regulation Of Protein Binding
Regulation Of Skeletal Muscle Tissue Development
Regulation Of Cellular Ketone Metabolic Process
Gliogenesis
Negative Regulation Of Growth
Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process
Protein K48-linked Ubiquitination
Protein Polyubiquitination
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Protein Catabolic Process
Protein K11-linked Ubiquitination
Cellular Macromolecule Catabolic Process
Cellular Protein Modification Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Proteolysis
Cellular Protein Metabolic Process
Catabolic Process
Protein Metabolic Process
Protein K63-linked Ubiquitination
Protein Monoubiquitination
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Regulation Of Innate Immune Response
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Activation Of Innate Immune Response
Protein K29-linked Ubiquitination
Cellular Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Positive Regulation Of Innate Immune Response
ISG15-protein Conjugation
Regulation Of DNA-templated Transcription In Response To Stress
TRIF-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Immune Response-regulating Signaling Pathway
Regulation Of Immune System Process
Regulation Of Immune Response
Toll-like Receptor 4 Signaling Pathway
Cellular Response To Hypoxia
Cellular Response To Decreased Oxygen Levels
Cellular Response To Stress
Toll-like Receptor Signaling Pathway
Cellular Response To Oxygen Levels
Positive Regulation Of Immune Response
Positive Regulation Of Protein Ubiquitination
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Protein Catabolic Process
Transcription Initiation From RNA Polymerase II Promoter
Mitotic Spindle Assembly Checkpoint
Tagcloud
?
artd
artd8
artd9
bal
bal1
bbap
chemo
deltex
diphtheria
du145
hpe
il4
immunoprecipitations
irf1
lncap
macrodomain
mono
mpca
parp14
parp9
pc3
proficient
repressors
ribosyltransferase
ribosyltransferases
rwpe1
stat1
stat6
Tagcloud (Difference)
?
artd
artd8
artd9
bal
bal1
bbap
chemo
deltex
diphtheria
du145
hpe
il4
immunoprecipitations
irf1
lncap
macrodomain
mono
mpca
parp14
parp9
pc3
proficient
repressors
ribosyltransferase
ribosyltransferases
rwpe1
stat1
stat6
Tagcloud (Intersection)
?