CRYAA and ZSCAN20

Number of citations of the paper that reports this interaction (PubMedID 24453475)
30

Data Source:
BioGRID (pull down)

		CRYAA	ZSCAN20
Description		crystallin alpha A	zinc finger and SCAN domain containing 20
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex	Nucleus
	Molecular Function	Structural Molecule Activity Structural Constituent Of Eye Lens Protein Binding Identical Protein Binding Metal Ion Binding Unfolded Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Response To Hypoxia Lens Development In Camera-type Eye Lens Morphogenesis In Camera-type Eye Apoptotic Process Mitochondrion Organization Actin Filament Organization Microtubule-based Process Tubulin Complex Assembly Visual Perception Response To Heat Negative Regulation Of Gene Expression Positive Regulation Of Cell Growth Negative Regulation Of Intracellular Transport Protein Refolding Response To Hydrogen Peroxide Camera-type Eye Development Negative Regulation Of Apoptotic Process Embryonic Camera-type Eye Morphogenesis Protein Stabilization Apoptotic Process Involved In Morphogenesis Response To UV-A Lens Fiber Cell Morphogenesis	Regulation Of Transcription By RNA Polymerase II
Pathways
Drugs
Diseases
GWAS		Age-related nuclear cataracts ( 24951543 33311586) Diastolic blood pressure ( 27618452 27841878 28135244 28739976) Metabolite levels ( 23823483) Systolic blood pressure ( 27618452 27841878 28739976)	Blood urea nitrogen levels ( 29403010) Neuropathic pain in type 2 diabetes ( 26629533) Urinary albumin excretion ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189)
Interacting Genes		134 interacting genes: - ADPRHL1 AKT3 ALB ALDH1L2 ANKRD44 APPL2 ARFGAP1 ARMCX4 ARRDC1-AS1 ATG16L1 BCL2L1 BORA BTRC CAMKK2 CD209 CDC40 CEBPZ CENPH CER1 CNOT8 COPB2 CRTAC1 CRYAB CRYBA1 CRYBB2 CRYGC CRYGD CRYZ CS CSTF2T DCAF11 DCAF8 DCK DDX3X DUS4L E2F7 EEPD1 ETFB EYA4 FAM131B FAM131C FAM182A FASN GIGYF2 GLYATL1 GNAI2 GORASP2 GSTZ1 HABP4 HCLS1 HSPB1 HSPB2 IGHG1 IGKV1-5 JKAMP KBTBD12 KIZ KNG1 LALBA LARP6 LIMA1 MAP3K7CL MAPKBP1 MCM7 MCRS1 MINDY1 MIP MPHOSPH6 MTERF4 MYO5C NAT9 NCF4 NTAQ1 NUP43 OSBPL3 OTOGL OTULIN PABIR2 PAFAH1B1 PCYT2 PHC1 PLAUR PMS2 PRM2 PSMB6 PTPN2 PTTG2 QRICH1 RAB24 RAB29 RAB3C RAB40B RAB43 RAD51 RBBP7 RNASEH1 RNGTT RPS6KA5 SDCBP SEC24C SEH1L SESN2 SGCD SLC20A1 SLC25A25 SLC25A26 SLC25A28 SPG21 SSBP4 SULF1 SYK TASL TEAD4 TFDP1 TGOLN2 TLE4 TMEM254 TMEM52B TSR3 TTC27 TTC39B TUBAL3 TUBGCP5 UBR2 UPP1 WDR55 WDR83 WIPI2 WWC2 ZIM2 ZNF3 ZNF639 ZSCAN20	4 interacting genes: CRYAA RIPK3 SCAND1 ZKSCAN4
Entrez ID		1409	7579
HPRD ID		00427	15769
Ensembl ID		ENSG00000160202	ENSG00000121903
Uniprot IDs		A0A8C8KJZ9 P02489	P17040
PDB IDs		6T1R
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Eye Lens Lens Development In Camera-type Eye	Response To Hydrogen Peroxide Response To Reactive Oxygen Species Identical Protein Binding Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway T Cell Differentiation Execution Phase Of Necroptosis Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Tubulin Complex Assembly Regulation Of Macromolecule Biosynthetic Process Lens Fiber Cell Morphogenesis Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Positive Regulation Of Gamma-delta T Cell Differentiation Positive Regulation Of Gamma-delta T Cell Activation Peptidyl-tyrosine Autophosphorylation CD8 Receptor Binding Phospholipase Activator Activity CD4 Receptor Binding CD27 Signaling Pathway Gamma-delta T Cell Differentiation Lymphocyte Differentiation Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Gamma-delta T Cell Differentiation Protein Antigen Binding T Cell Activation Necroptotic Signaling Pathway Regulation Of Activation-induced Cell Death Of T Cells Positive Regulation Of Necroptotic Process Positive Regulation Of Programmed Necrotic Cell Death Response To UV-A Positive Regulation Of Heterotypic Cell-cell Adhesion T Cell Receptor Binding Mononuclear Cell Differentiation Response To Oxidative Stress Embryonic Camera-type Eye Morphogenesis Lens Morphogenesis In Camera-type Eye Necroptotic Process Regulation Of Apoptotic Process Regulation Of Metabolic Process Leukocyte Differentiation Phosphatidylinositol 3-kinase Binding Regulation Of Apoptotic Signaling Pathway Regulation Of T Cell Activation Regulation Of Programmed Cell Death Positive Regulation Of T Cell Receptor Signaling Pathway Lymph Node Development Structural Constituent Of Eye Lens Gamma-delta T Cell Activation Phospholipase Binding
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