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SPG21 and CD4
Number of citations of the paper that reports this interaction (PMID
11113139
)
7
Data Source:
HPRD
(two hybrid, in vivo)
SPG21
CD4
Gene Name
spastic paraplegia 21 (autosomal recessive, Mast syndrome)
CD4 molecule
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Endosome Membrane
Trans-Golgi Network Transport Vesicle
Early Endosome
Endoplasmic Reticulum Lumen
Endoplasmic Reticulum Membrane
Plasma Membrane
External Side Of Plasma Membrane
Integral Component Of Membrane
T Cell Receptor Complex
Membrane Raft
Molecular Function
Protein Binding
CD4 Receptor Binding
Glycoprotein Binding
Receptor Activity
Transmembrane Signaling Receptor Activity
Extracellular Matrix Structural Constituent
Protein Binding
Zinc Ion Binding
Coreceptor Activity
Enzyme Binding
Protein Kinase Binding
MHC Class II Protein Binding
Protein Homodimerization Activity
Biological Process
Antigen Receptor-mediated Signaling Pathway
Cytokine Production
Induction By Virus Of Host Cell-cell Fusion
Immune Response
Signal Transduction
Cell Surface Receptor Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Viral Process
T Cell Differentiation
Entry Into Host Cell
T Cell Costimulation
Maintenance Of Protein Location In Cell
T Cell Selection
Positive Regulation Of Interleukin-2 Biosynthetic Process
Innate Immune Response
Protein Palmitoleylation
Positive Regulation Of Protein Kinase Activity
Regulation Of Defense Response To Virus By Virus
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Defense Response To Gram-negative Bacterium
Positive Regulation Of Calcium-mediated Signaling
T Cell Receptor Signaling Pathway
Regulation Of T Cell Activation
Pathways
Vpu mediated degradation of CD4
Downstream TCR signaling
Generation of second messenger molecules
Translocation of ZAP-70 to Immunological synapse
Costimulation by the CD28 family
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
HIV Infection
Host Interactions of HIV factors
The role of Nef in HIV-1 replication and disease pathogenesis
Early Phase of HIV Life Cycle
HIV Life Cycle
TCR signaling
Alpha-defensins
PD-1 signaling
Defensins
Phosphorylation of CD3 and TCR zeta chains
Nef Mediated CD4 Down-regulation
Binding and entry of HIV virion
Innate Immune System
Adaptive Immune System
Drugs
Diseases
GWAS
Response to Vitamin E supplementation (
22437554
)
Protein-Protein Interactions
37 interactors:
AGTRAP
AKIRIN2
ARL6IP1
ATPAF2
CCDC102B
CCDC33
CD4
CMTM5
CRYAA
CTPS2
CUTC
DTX2
DTX3L
EFHC2
FAM114A1
GGA2
GSK3A
IKZF3
INCA1
KRT15
MID2
MTMR9
PRPS1
RABAC1
REEP6
RTN4
S100B
SPRED2
TCF12
TCF4
TFG
TRAF1
TRAF2
TRIM23
TRIM54
TRIM9
ZNF263
38 interactors:
ABCB1
ADRB2
CCR5
CD2
CD28
CD38
CD44
CD5
CD53
CD82
CTSD
CXCL12
CXCR4
DPP4
FCGR3A
HLA-DPA1
HLA-DQA2
HLA-DQB1
IL16
IL2RA
INPPL1
KCNAB2
LAT
LCK
LGALS1
MAPK14
MARCH4
PI4KA
PIK3R1
PIP
PTPRC
SELL
SIVA1
SPG21
TFRC
TNFRSF10A
UBL7
UNC119
Entrez ID
51324
920
HPRD ID
10492
01740
Ensembl ID
ENSG00000090487
ENSG00000010610
Uniprot IDs
Q9NZD8
B0AZV7
B4DT49
P01730
PDB IDs
1CDH
1CDI
1CDJ
1CDU
1CDY
1G9M
1G9N
1GC1
1JL4
1OPN
1OPT
1OPW
1Q68
1RZJ
1RZK
1WBR
1WIO
1WIP
1WIQ
2B4C
2JKR
2JKT
2KLU
2NXY
2NXZ
2NY0
2NY1
2NY2
2NY3
2NY4
2NY5
2NY6
2QAD
3B71
3CD4
3JWD
3JWO
3LQA
3O2D
3S4S
3S5L
3T0E
4JM2
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Apoptotic Process
Protein Ubiquitination
Regulation Of Cell Death
Protein Modification By Small Protein Conjugation
Negative Regulation Of Developmental Growth
Innate Immune Response
Positive Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of Striated Muscle Tissue Development
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Positive Regulation Of Interleukin-2 Production
Positive Regulation Of Cell Death
Immune Response
Negative Regulation Of Organ Growth
Negative Regulation Of UDP-glucose Catabolic Process
Induction By Virus Of Host Cell-cell Fusion
Protein Palmitoleylation
Regulation Of Intracellular Signal Transduction
Negative Regulation Of Muscle Cell Differentiation
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of Striated Muscle Tissue Development
Regulation Of Cellular Localization
Negative Regulation Of Muscle Organ Development
Regulation Of Signal Transduction
Positive Regulation Of Apoptotic Signaling Pathway
Regulation Of Extrinsic Apoptotic Signaling Pathway
Pyrimidine Nucleotide Biosynthetic Process
Regulation Of Intracellular Transport
Negative Regulation Of Cell Differentiation
Regulation Of Protein Kinase Activity
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Negative Regulation Of Type B Pancreatic Cell Development
Negative Regulation Of SNARE Complex Assembly
Catenin Import Into Nucleus
Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition
Urate Biosynthetic Process
'de Novo' CTP Biosynthetic Process
Glycogen Metabolic Process
Regulation Of Kinase Activity
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Regulation Of Cell Differentiation
Positive Regulation Of Protein Binding
Regulation Of Skeletal Muscle Tissue Development
Regulation Of Cellular Ketone Metabolic Process
Gliogenesis
Negative Regulation Of Growth
Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process
Immune System Process
Regulation Of Cell-cell Adhesion
Positive Regulation Of Immune System Process
Regulation Of Immune System Process
Regulation Of T Cell Activation
Regulation Of Lymphocyte Activation
Positive Regulation Of Homotypic Cell-cell Adhesion
Positive Regulation Of Cell Activation
Positive Regulation Of Cell-cell Adhesion
T Cell Costimulation
Regulation Of Cell Activation
Positive Regulation Of Cell Adhesion
Regulation Of Cell Adhesion
Antigen Receptor-mediated Signaling Pathway
Positive Regulation Of T Cell Activation
Immune Response-activating Cell Surface Receptor Signaling Pathway
Response To Stimulus
Immune Response-regulating Signaling Pathway
T Cell Receptor Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Regulation Of Immune Response
Positive Regulation Of Immune Response
Signaling
Immune Response
Cell Communication
Signal Transduction
Cell Surface Receptor Signaling Pathway
Lymphocyte Activation
Leukocyte Aggregation
Cellular Response To Stimulus
Apoptotic Process
Leukocyte Cell-cell Adhesion
Homotypic Cell-cell Adhesion
Programmed Cell Death
Response To Stress
Leukocyte Migration
Leukocyte Activation
Cell Death
Death
Cell Activation
Defense Response
Homeostatic Process
T Cell Aggregation
T Cell Activation
Lymphocyte Aggregation
Locomotion
Cell Migration
Cell Motility
Single Organismal Cell-cell Adhesion
Cellular Chemical Homeostasis
Tagcloud
?
allergen
asthmatics
box
caat
cd18
chemotactic
coactivator
complexity
concert
consists
dyad
exons
ga
gabp
gabpalpha
harbor
inducible
introns
lymphocytes
mast
motifs
posttranslational
pro
processed
remote
share
supplementing
symmetry
tata
tightly
Tagcloud (Difference)
?
allergen
asthmatics
box
caat
cd18
chemotactic
coactivator
complexity
concert
consists
dyad
exons
ga
gabp
gabpalpha
harbor
inducible
introns
lymphocytes
mast
motifs
posttranslational
pro
processed
remote
share
supplementing
symmetry
tata
tightly
Tagcloud (Intersection)
?