SPG21 and CD4

Number of citations of the paper that reports this interaction (PubMedID 11113139)
0

Data Source:
HPRD (two hybrid, in vivo)

		SPG21	CD4
Description		SPG21 abhydrolase domain containing, maspardin	CD4 molecule
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Golgi Apparatus Cytosol Endosome Membrane Membrane Trans-Golgi Network Transport Vesicle	Early Endosome Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Clathrin-coated Endocytic Vesicle Membrane T Cell Receptor Complex Membrane Raft
	Molecular Function	Protein Binding CD4 Receptor Binding	Virus Receptor Activity Transmembrane Signaling Receptor Activity Signaling Receptor Binding Extracellular Matrix Structural Constituent Protein Binding Zinc Ion Binding Lipid Binding Coreceptor Activity Immunoglobulin Binding Enzyme Binding Protein Kinase Binding MHC Class II Protein Complex Binding Signaling Receptor Activity Interleukin-16 Binding Interleukin-16 Receptor Activity MHC Class II Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein Tyrosine Kinase Binding
	Biological Process	Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Locomotory Behavior Gene Expression Neuron Maturation Collateral Sprouting Antigen Receptor-mediated Signaling Pathway Neuromuscular Process Limb Development Response To Epidermal Growth Factor	Positive Regulation Of Protein Phosphorylation Adaptive Immune Response Immune System Process Positive Regulation Of Immune System Process Immune Response Cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Calcium Ion Transport Into Cytosol Calcium-mediated Signaling T Cell Differentiation Macrophage Differentiation Response To Estradiol Maintenance Of Protein Location In Cell Positive Regulation Of Interleukin-2 Production Response To Vitamin D Positive Regulation Of Kinase Activity Helper T Cell Enhancement Of Adaptive Immune Response Interleukin-15-mediated Signaling Pathway Positive Regulation Of T Cell Proliferation T Cell Activation Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade T Cell Selection Response To Ethanol Positive Regulation Of Monocyte Differentiation Positive Regulation Of Protein Kinase Activity Positive Regulation Of DNA-templated Transcription Positive Regulation Of Viral Entry Into Host Cell Symbiont Entry Into Host Cell Defense Response To Gram-negative Bacterium Positive Regulation Of Calcium-mediated Signaling Regulation Of T Cell Activation Positive Regulation Of T Cell Activation Positive Regulation Of Multicellular Organismal Process Regulation Of Calcium Ion Transport Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Response To Methamphetamine Hydrochloride Cellular Response To Ionomycin
Pathways			Alpha-defensins Nef Mediated CD4 Down-regulation Binding and entry of HIV virion Vpu mediated degradation of CD4 Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules Co-inhibition by PD-1 Other interleukin signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs			Antithymocyte immunoglobulin (rabbit) Clenoliximab Ibalizumab
Diseases		Hereditary spastic paraplegia (SPG)
GWAS			Bone mineral density (hip) ( 30172743) Response to Vitamin E supplementation ( 22437554)
Interacting Genes		161 interacting genes: - ACOT13 AGTR1 AGTRAP AKIRIN2 APOC1 ARL6IP1 ARMC12 ARMC7 ATP5ME BORCS6 BSND CCDC102B CCDC33 CCHCR1 CD4 CDK2AP1 CDKN2B CEP76 CEPT1 CFAP410 CIDEB CLDN22 CMTM4 CMTM5 CMTM6 COG3 COG6 CPSF7 CRX CRYAA CT55 CTIF CTPS2 CUTC DCTPP1 DRC12 DRC4 DTX3L EFHC2 EIF1B EIF4H EYA2 FAM114A1 FAM86C1P FBXO44 FLACC1 GAD2 GEMIN2 GEMIN4 GGA2 GOLGA2 GOLT1B GRPEL1 GSK3A HNRNPH1 HPRT1 HSD17B13 IKZF3 INCA1 IQCB1 KCTD9 KRT13 KRT15 KRT19 KRT31 LEPROTL1 LMNA LMO1 LNX1 LSMEM2 MAB21L3 MID2 MPC2 MTMR9 MTUS2 MYG1 MYOG N4BP3 NAB2 NDUFAF2 NIF3L1 NME4 NQO2 NR1D1 NRDE2 NUP54 PAX6 PBX4 PCBD2 PCNA PDE5A PEF1 PFDN5 PLP2 PNMA5 PPM1J PRPS1 PRTFDC1 PSMB4 PTPA RABAC1 RAD51C REEP6 REL ROPN1 RPRD1B RPS19 RTL8B RTN4 S100B SATB1 SCAMP1 SEPTIN5 SFT2D1 SH3GL1 SLC35E3 SORBS3 SPMIP5 SPMIP6 SPRED1 SPRED2 SRGAP2B SSBP4 SWSAP1 SYNGR1 SYNGR3 SYP TCF12 TCF4 TEKT4 TFG TFIP11 TLE5 TMEM208 TMEM239 TOX2 TPD52 TRAF1 TRAF2 TRIB3 TRIM14 TRIM23 TRIM50 TRIM54 TRIM9 TSGA10IP TSNAXIP1 TTC23L TXN TXNL4B UFSP1 USHBP1 VMAC VPS25 YPEL3 ZBTB42 ZMYND12 ZNF263 ZNF581 ZNF629	39 interacting genes: ABCB1 ADORA2A ADRB2 CCR5 CD2 CD28 CD38 CD44 CD5 CD53 CD82 CTSD CXCL12 CXCR4 DPP4 FCGR3A HLA-DPA1 HLA-DQA2 HLA-DQB1 IL16 IL2RA INPPL1 KCNAB2 LAT LCK LGALS1 MAPK14 MARCHF4 PI4KA PIK3R1 PIP PTPRC SELL SIVA1 SPG21 TFRC TNFRSF10A UBL7 UNC119
Entrez ID		51324	920
HPRD ID		10492	01740
Ensembl ID		ENSG00000090487	ENSG00000010610
Uniprot IDs		Q9NZD8	A0A4Y5UGE4 B0AZV7 B4DT49 P01730
PDB IDs			1CDH 1CDI 1CDJ 1CDU 1CDY 1G9M 1G9N 1GC1 1JL4 1Q68 1RZJ 1RZK 1WBR 1WIO 1WIP 1WIQ 2B4C 2JKR 2JKT 2KLU 2NXY 2NXZ 2NY0 2NY1 2NY2 2NY3 2NY4 2NY5 2NY6 2QAD 3B71 3CD4 3J70 3JCB 3JCC 3JWD 3JWO 3LQA 3O2D 3S4S 3S5L 3T0E 4H8W 4JM2 4P9H 4Q6I 4R2G 4R4H 4RQS 5A7X 5A8H 5CAY 5THR 5U1F 5VN3 6CM3 6EDU 6L1Y 6MEO 6MET 6OPN 6OPO 6OPP 6OPQ 6QH6 6QH7 6U0L 6U0N 6URI 6X5B 6X5C 7T0O 7T0R 7TXD 8D5C 8FYI 8FYJ 8W90 8Z7N
Enriched GO Terms of Interacting Partners?		Protein Binding Identical Protein Binding Motile Cilium Structural Molecule Activity Guanine Salvage Purine Nucleobase Biosynthetic Process Hypoxanthine Phosphoribosyltransferase Activity Flagellated Sperm Motility Sperm Motility Cilium-dependent Cell Motility Sperm Flagellum Cilium Movement Involved In Cell Motility Hypoxanthine Biosynthetic Process Protein-containing Complex Organization	Immune System Process Regulation Of Immune System Process Positive Regulation Of Immune System Process Positive Regulation Of Cell Activation Regulation Of Lymphocyte Activation Regulation Of Cell Activation Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Regulation Of Cell Adhesion Positive Regulation Of Leukocyte Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cell-cell Adhesion Regulation Of Immune Response Positive Regulation Of T Cell Activation Positive Regulation Of Cell Adhesion Antigen Receptor-mediated Signaling Pathway Plasma Membrane Cell Activation External Side Of Plasma Membrane Lymphocyte Activation Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Surface Signal Transduction Leukocyte Activation Immune Response-activating Cell Surface Receptor Signaling Pathway T Cell Receptor Signaling Pathway Regulation Of Multicellular Organismal Process Positive Regulation Of Immune Response T Cell Activation Immune Response-regulating Signaling Pathway Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation T Cell Costimulation Immune Response-activating Signaling Pathway Positive Regulation Of Leukocyte Proliferation Defense Response Immune Response Activation Of Immune Response Membrane Raft Distribution Clathrin-coated Endocytic Vesicle Membrane Apoptotic Signaling Pathway Membrane Raft Localization Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Leukocyte Migration Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II MHC Class II Receptor Activity
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