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SPG21 and MID2
Number of citations of the paper that reports this interaction (PMID
25416956
)
0
Data Source:
BioGRID
(two hybrid)
SPG21
MID2
Gene Name
spastic paraplegia 21 (autosomal recessive, Mast syndrome)
midline 2
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Endosome Membrane
Trans-Golgi Network Transport Vesicle
Cytoplasm
Microtubule
Extracellular Vesicular Exosome
Molecular Function
Protein Binding
CD4 Receptor Binding
Microtubule Binding
Zinc Ion Binding
Ligase Activity
Protein Homodimerization Activity
Protein Heterodimerization Activity
Phosphoprotein Binding
Biological Process
Antigen Receptor-mediated Signaling Pathway
Protein Ubiquitination
Negative Regulation Of Viral Transcription
Protein Localization To Microtubule
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Innate Immune Response
Negative Regulation Of Viral Entry Into Host Cell
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Positive Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of Viral Release From Host Cell
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions
37 interactors:
AGTRAP
AKIRIN2
ARL6IP1
ATPAF2
CCDC102B
CCDC33
CD4
CMTM5
CRYAA
CTPS2
CUTC
DTX2
DTX3L
EFHC2
FAM114A1
GGA2
GSK3A
IKZF3
INCA1
KRT15
MID2
MTMR9
PRPS1
RABAC1
REEP6
RTN4
S100B
SPRED2
TCF12
TCF4
TFG
TRAF1
TRAF2
TRIM23
TRIM54
TRIM9
ZNF263
108 interactors:
ADAMTSL4
AEN
AQP1
ATRIP
BCL6B
BRCA1
BRMS1L
BYSL
C19orf66
CALCOCO2
CBX8
CCDC120
CCDC42
CCHCR1
CEP57L1
CHD2
CTSZ
DCX
DGCR6
DGCR6L
DIEXF
DMRT3
DYDC1
FAM107A
FAM161A
FAM214A
FAM90A1
FARS2
FBF1
FBXL18
FRMD6
GFI1B
GMCL1
GOLGA2
GORASP2
HOXB9
IGBP1
ISCU
JOSD1
KIAA1683
KIF1A
KIFC3
LENG1
LGALS14
LGALS8
MAGOHB
METTL17
MFAP1
MID1
MID1IP1
MOS
MVP
NR1D2
NXF1
OTUB2
PPP1R18
PRPF31
PSMA1
PTCD2
RCOR3
RPH3AL
RPP25L
RUNX1T1
SCNM1
SDCBP
SLC25A48
SLC25A6
SNAI1
SNAP47
SPATA24
SPG21
SPRY2
STX11
SYT17
TCEA2
TCEB3
THAP7
TOP3B
TRIM27
TRIM29
TRIM32
TRIM42
TRIM54
TRPV6
TSGA10
UBE2D1
UBE2D4
UBE2E2
UBE2E3
UBE2U
UBTD1
UNC45A
UTP23
WT1-AS
ZBTB24
ZC2HC1C
ZFYVE21
ZGPAT
ZNF165
ZNF24
ZNF250
ZNF417
ZNF440
ZNF564
ZNF587
ZNF785
ZNF792
ZSCAN12
Entrez ID
51324
11043
HPRD ID
10492
02191
Ensembl ID
ENSG00000090487
Uniprot IDs
Q9NZD8
Q9UJV3
PDB IDs
2DJA
2DMK
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Apoptotic Process
Protein Ubiquitination
Regulation Of Cell Death
Protein Modification By Small Protein Conjugation
Negative Regulation Of Developmental Growth
Innate Immune Response
Positive Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of Striated Muscle Tissue Development
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Positive Regulation Of Interleukin-2 Production
Positive Regulation Of Cell Death
Immune Response
Negative Regulation Of Organ Growth
Negative Regulation Of UDP-glucose Catabolic Process
Induction By Virus Of Host Cell-cell Fusion
Protein Palmitoleylation
Regulation Of Intracellular Signal Transduction
Negative Regulation Of Muscle Cell Differentiation
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of Striated Muscle Tissue Development
Regulation Of Cellular Localization
Negative Regulation Of Muscle Organ Development
Regulation Of Signal Transduction
Positive Regulation Of Apoptotic Signaling Pathway
Regulation Of Extrinsic Apoptotic Signaling Pathway
Pyrimidine Nucleotide Biosynthetic Process
Regulation Of Intracellular Transport
Negative Regulation Of Cell Differentiation
Regulation Of Protein Kinase Activity
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Negative Regulation Of Type B Pancreatic Cell Development
Negative Regulation Of SNARE Complex Assembly
Catenin Import Into Nucleus
Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition
Urate Biosynthetic Process
'de Novo' CTP Biosynthetic Process
Glycogen Metabolic Process
Regulation Of Kinase Activity
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Regulation Of Cell Differentiation
Positive Regulation Of Protein Binding
Regulation Of Skeletal Muscle Tissue Development
Regulation Of Cellular Ketone Metabolic Process
Gliogenesis
Negative Regulation Of Growth
Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process
RNA Metabolic Process
Nucleobase-containing Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Gene Expression
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Transcription, DNA-templated
Nitrogen Compound Metabolic Process
RNA Biosynthetic Process
Protein Polyubiquitination
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Regulation Of Nitrogen Compound Metabolic Process
Negative Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Protein K63-linked Ubiquitination
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Negative Regulation Of Transcription, DNA-templated
Protein K48-linked Ubiquitination
Negative Regulation Of Nucleic Acid-templated Transcription
Biosynthetic Process
Cellular Process
Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Negative Regulation Of Biosynthetic Process
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Negative Regulation Of Cellular Metabolic Process
Protein K11-linked Ubiquitination
Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA)
Maturation Of SSU-rRNA
Cellular Metabolic Process
Negative Regulation Of Microtubule Depolymerization
Protein K6-linked Ubiquitination
Regulation Of Microtubule-based Process
Ribosomal Small Subunit Biogenesis
Regulation Of Metabolic Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Microtubule Polymerization Or Depolymerization
Synaptic Vesicle Fusion To Presynaptic Membrane
Negative Regulation Of Transferase Activity
Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Viral Release From Host Cell
Negative Regulation Of Protein Tyrosine Kinase Activity
Regulation Of Microtubule Cytoskeleton Organization
Regulation Of Viral Transcription
Regulation Of Histone H3-K4 Methylation
Regulation Of Microtubule Polymerization Or Depolymerization
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