CRYAA and SULF1

Number of citations of the paper that reports this interaction (PubMedID 24453475)
30

Data Source:
BioGRID (pull down)

		CRYAA	SULF1
Description		crystallin alpha A	sulfatase 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex	Extracellular Region Extracellular Space Endoplasmic Reticulum Golgi Apparatus Golgi Stack Plasma Membrane Cell Surface Extracellular Matrix Membrane Raft
	Molecular Function	Structural Molecule Activity Structural Constituent Of Eye Lens Protein Binding Identical Protein Binding Metal Ion Binding Unfolded Protein Binding	Arylsulfatase Activity Calcium Ion Binding Glycosaminoglycan Binding N-acetylglucosamine-6-sulfatase Activity Sulfuric Ester Hydrolase Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Response To Hypoxia Lens Development In Camera-type Eye Lens Morphogenesis In Camera-type Eye Apoptotic Process Mitochondrion Organization Actin Filament Organization Microtubule-based Process Tubulin Complex Assembly Visual Perception Response To Heat Negative Regulation Of Gene Expression Positive Regulation Of Cell Growth Negative Regulation Of Intracellular Transport Protein Refolding Response To Hydrogen Peroxide Camera-type Eye Development Negative Regulation Of Apoptotic Process Embryonic Camera-type Eye Morphogenesis Protein Stabilization Apoptotic Process Involved In Morphogenesis Response To UV-A Lens Fiber Cell Morphogenesis	Kidney Development Negative Regulation Of Endothelial Cell Proliferation Chondrocyte Development Glomerular Filtration Apoptotic Process Positive Regulation Of Vascular Endothelial Growth Factor Production Esophagus Smooth Muscle Contraction Negative Regulation Of Angiogenesis Positive Regulation Of Wnt Signaling Pathway Heparan Sulfate Proteoglycan Metabolic Process Negative Regulation Of Cell Migration Positive Regulation Of BMP Signaling Pathway Glomerular Basement Membrane Development Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Embryonic Skeletal System Development Cartilage Development Bone Development Innervation Negative Regulation Of Prostatic Bud Formation
Pathways
Drugs
Diseases
GWAS		Age-related nuclear cataracts ( 24951543 33311586) Diastolic blood pressure ( 27618452 27841878 28135244 28739976) Metabolite levels ( 23823483) Systolic blood pressure ( 27618452 27841878 28739976)	Cervical cancer ( 28806749) Crohn's disease ( 32581322) Dupuytren's disease ( 21732829) Evening vs. morning chronotype (sMEQ score) ( 32579418) Fasting blood insulin (BMI interaction) ( 22581228) Femur bone mineral density x serum urate levels interaction ( 34046847) Height ( 21998595) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Thyroid stimulating hormone levels ( 30367059 32769997)
Interacting Genes		134 interacting genes: - ADPRHL1 AKT3 ALB ALDH1L2 ANKRD44 APPL2 ARFGAP1 ARMCX4 ARRDC1-AS1 ATG16L1 BCL2L1 BORA BTRC CAMKK2 CD209 CDC40 CEBPZ CENPH CER1 CNOT8 COPB2 CRTAC1 CRYAB CRYBA1 CRYBB2 CRYGC CRYGD CRYZ CS CSTF2T DCAF11 DCAF8 DCK DDX3X DUS4L E2F7 EEPD1 ETFB EYA4 FAM131B FAM131C FAM182A FASN GIGYF2 GLYATL1 GNAI2 GORASP2 GSTZ1 HABP4 HCLS1 HSPB1 HSPB2 IGHG1 IGKV1-5 JKAMP KBTBD12 KIZ KNG1 LALBA LARP6 LIMA1 MAP3K7CL MAPKBP1 MCM7 MCRS1 MINDY1 MIP MPHOSPH6 MTERF4 MYO5C NAT9 NCF4 NTAQ1 NUP43 OSBPL3 OTOGL OTULIN PABIR2 PAFAH1B1 PCYT2 PHC1 PLAUR PMS2 PRM2 PSMB6 PTPN2 PTTG2 QRICH1 RAB24 RAB29 RAB3C RAB40B RAB43 RAD51 RBBP7 RNASEH1 RNGTT RPS6KA5 SDCBP SEC24C SEH1L SESN2 SGCD SLC20A1 SLC25A25 SLC25A26 SLC25A28 SPG21 SSBP4 SULF1 SYK TASL TEAD4 TFDP1 TGOLN2 TLE4 TMEM254 TMEM52B TSR3 TTC27 TTC39B TUBAL3 TUBGCP5 UBR2 UPP1 WDR55 WDR83 WIPI2 WWC2 ZIM2 ZNF3 ZNF639 ZSCAN20	5 interacting genes: APP CRYAA DSCR9 DYRK1A NEDD4
Entrez ID		1409	23213
HPRD ID		00427	15450
Ensembl ID		ENSG00000160202	ENSG00000137573
Uniprot IDs		A0A8C8KJZ9 P02489	Q8IWU6
PDB IDs		6T1R
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Eye Lens Lens Development In Camera-type Eye	Amyloid-beta Complex Regulation Of Amyloid Precursor Protein Catabolic Process Growth Cone Lamellipodium Response To Light Stimulus Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Response To Radiation Histone H3T45 Kinase Activity Formation Of Structure Involved In A Symbiotic Process Acetylcholine Receptor Activator Activity PTB Domain Binding Regulation Of Spontaneous Synaptic Transmission Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition NMDA Selective Glutamate Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Protein Catabolic Process Regulation Of Synapse Structure Or Activity Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Endothelin Production Negative Regulation Of Macromolecule Biosynthetic Process Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Regulation Of Toll Signaling Pathway Protein-containing Complex Negative Regulation Of Biosynthetic Process Lipoprotein Particle Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Response To UV Negative Regulation Of Heterochromatin Formation Regulation Of Neurofibrillary Tangle Assembly Splicing Factor Binding Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Channel Inhibitor Activity Phosphoserine Residue Binding Nuclear Receptor-mediated Corticosteroid Signaling Pathway Beta-2 Adrenergic Receptor Binding
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