SPG21 and LSMEM2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SPG21	LSMEM2
Description		SPG21 abhydrolase domain containing, maspardin	leucine rich single-pass membrane protein 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Golgi Apparatus Cytosol Endosome Membrane Membrane Trans-Golgi Network Transport Vesicle	Membrane
	Molecular Function	Protein Binding CD4 Receptor Binding	Protein Binding
	Biological Process	Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Locomotory Behavior Gene Expression Neuron Maturation Collateral Sprouting Antigen Receptor-mediated Signaling Pathway Neuromuscular Process Limb Development Response To Epidermal Growth Factor
Pathways
Drugs
Diseases		Hereditary spastic paraplegia (SPG)
GWAS			Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Depressive symptom (appetite changes) (binary trait) ( 31530331) Depressive symptoms (binary sum-score) ( 31530331) Depressive symptoms (sum-score) ( 31530331) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		161 interacting genes: - ACOT13 AGTR1 AGTRAP AKIRIN2 APOC1 ARL6IP1 ARMC12 ARMC7 ATP5ME BORCS6 BSND CCDC102B CCDC33 CCHCR1 CD4 CDK2AP1 CDKN2B CEP76 CEPT1 CFAP410 CIDEB CLDN22 CMTM4 CMTM5 CMTM6 COG3 COG6 CPSF7 CRX CRYAA CT55 CTIF CTPS2 CUTC DCTPP1 DRC12 DRC4 DTX3L EFHC2 EIF1B EIF4H EYA2 FAM114A1 FAM86C1P FBXO44 FLACC1 GAD2 GEMIN2 GEMIN4 GGA2 GOLGA2 GOLT1B GRPEL1 GSK3A HNRNPH1 HPRT1 HSD17B13 IKZF3 INCA1 IQCB1 KCTD9 KRT13 KRT15 KRT19 KRT31 LEPROTL1 LMNA LMO1 LNX1 LSMEM2 MAB21L3 MID2 MPC2 MTMR9 MTUS2 MYG1 MYOG N4BP3 NAB2 NDUFAF2 NIF3L1 NME4 NQO2 NR1D1 NRDE2 NUP54 PAX6 PBX4 PCBD2 PCNA PDE5A PEF1 PFDN5 PLP2 PNMA5 PPM1J PRPS1 PRTFDC1 PSMB4 PTPA RABAC1 RAD51C REEP6 REL ROPN1 RPRD1B RPS19 RTL8B RTN4 S100B SATB1 SCAMP1 SEPTIN5 SFT2D1 SH3GL1 SLC35E3 SORBS3 SPMIP5 SPMIP6 SPRED1 SPRED2 SRGAP2B SSBP4 SWSAP1 SYNGR1 SYNGR3 SYP TCF12 TCF4 TEKT4 TFG TFIP11 TLE5 TMEM208 TMEM239 TOX2 TPD52 TRAF1 TRAF2 TRIB3 TRIM14 TRIM23 TRIM50 TRIM54 TRIM9 TSGA10IP TSNAXIP1 TTC23L TXN TXNL4B UFSP1 USHBP1 VMAC VPS25 YPEL3 ZBTB42 ZMYND12 ZNF263 ZNF581 ZNF629	19 interacting genes: APP CD72 CLDN7 CLEC12B CTXN3 CXCL9 EMP1 GIMAP5 KLRC1 LSMEM1 PLN SEC22A SFTPC SGTA SMIM3 SPACA1 SPG21 TMEM143 TMEM218
Entrez ID		51324	132228
HPRD ID		10492	08789
Ensembl ID		ENSG00000090487	ENSG00000179564
Uniprot IDs		Q9NZD8	Q8N112
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Binding Identical Protein Binding Motile Cilium Structural Molecule Activity Guanine Salvage Purine Nucleobase Biosynthetic Process Hypoxanthine Phosphoribosyltransferase Activity Flagellated Sperm Motility Sperm Motility Cilium-dependent Cell Motility Sperm Flagellum Cilium Movement Involved In Cell Motility Hypoxanthine Biosynthetic Process Protein-containing Complex Organization	Natural Killer Cell Inhibitory Signaling Pathway Membrane Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Immune Response-inhibiting Signal Transduction Collateral Sprouting Negative Regulation Of Blood Circulation Regulation Of Calcium Ion Transmembrane Transport Neuron Maturation External Side Of Plasma Membrane Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Acrosome Assembly Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Carbohydrate Binding Inhibitory MHC Class Ib Receptor Activity Circadian Sleep/wake Cycle, Sleep Phospholamban Complex Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process Locomotory Behavior
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