CRYAA and SLC20A1

Number of citations of the paper that reports this interaction (PubMedID 24453475)
30

Data Source:
BioGRID (pull down)

		CRYAA	SLC20A1
Description		crystallin alpha A	solute carrier family 20 member 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex	Plasma Membrane Membrane
	Molecular Function	Structural Molecule Activity Structural Constituent Of Eye Lens Protein Binding Identical Protein Binding Metal Ion Binding Unfolded Protein Binding	Phosphate Transmembrane Transporter Activity High-affinity Phosphate:sodium Symporter Activity Sodium:phosphate Symporter Activity Symporter Activity Signaling Receptor Activity
	Biological Process	Response To Hypoxia Lens Development In Camera-type Eye Lens Morphogenesis In Camera-type Eye Apoptotic Process Mitochondrion Organization Actin Filament Organization Microtubule-based Process Tubulin Complex Assembly Visual Perception Response To Heat Negative Regulation Of Gene Expression Positive Regulation Of Cell Growth Negative Regulation Of Intracellular Transport Protein Refolding Response To Hydrogen Peroxide Camera-type Eye Development Negative Regulation Of Apoptotic Process Embryonic Camera-type Eye Morphogenesis Protein Stabilization Apoptotic Process Involved In Morphogenesis Response To UV-A Lens Fiber Cell Morphogenesis	Phosphate-containing Compound Metabolic Process Monoatomic Ion Transport Sodium Ion Transport Phosphate Ion Transport Cell Population Proliferation Biomineral Tissue Development Phosphate Ion Transmembrane Transport Sodium Ion Transmembrane Transport Positive Regulation Of Canonical NF-kappaB Signal Transduction
Pathways			Sodium-coupled phosphate cotransporters
Drugs
Diseases
GWAS		Age-related nuclear cataracts ( 24951543 33311586) Diastolic blood pressure ( 27618452 27841878 28135244 28739976) Metabolite levels ( 23823483) Systolic blood pressure ( 27618452 27841878 28739976)
Interacting Genes		134 interacting genes: - ADPRHL1 AKT3 ALB ALDH1L2 ANKRD44 APPL2 ARFGAP1 ARMCX4 ARRDC1-AS1 ATG16L1 BCL2L1 BORA BTRC CAMKK2 CD209 CDC40 CEBPZ CENPH CER1 CNOT8 COPB2 CRTAC1 CRYAB CRYBA1 CRYBB2 CRYGC CRYGD CRYZ CS CSTF2T DCAF11 DCAF8 DCK DDX3X DUS4L E2F7 EEPD1 ETFB EYA4 FAM131B FAM131C FAM182A FASN GIGYF2 GLYATL1 GNAI2 GORASP2 GSTZ1 HABP4 HCLS1 HSPB1 HSPB2 IGHG1 IGKV1-5 JKAMP KBTBD12 KIZ KNG1 LALBA LARP6 LIMA1 MAP3K7CL MAPKBP1 MCM7 MCRS1 MINDY1 MIP MPHOSPH6 MTERF4 MYO5C NAT9 NCF4 NTAQ1 NUP43 OSBPL3 OTOGL OTULIN PABIR2 PAFAH1B1 PCYT2 PHC1 PLAUR PMS2 PRM2 PSMB6 PTPN2 PTTG2 QRICH1 RAB24 RAB29 RAB3C RAB40B RAB43 RAD51 RBBP7 RNASEH1 RNGTT RPS6KA5 SDCBP SEC24C SEH1L SESN2 SGCD SLC20A1 SLC25A25 SLC25A26 SLC25A28 SPG21 SSBP4 SULF1 SYK TASL TEAD4 TFDP1 TGOLN2 TLE4 TMEM254 TMEM52B TSR3 TTC27 TTC39B TUBAL3 TUBGCP5 UBR2 UPP1 WDR55 WDR83 WIPI2 WWC2 ZIM2 ZNF3 ZNF639 ZSCAN20	4 interacting genes: BCL10 CRYAA MAPK6 RAPGEF1
Entrez ID		1409	6574
HPRD ID		00427	08846
Ensembl ID		ENSG00000160202	ENSG00000144136
Uniprot IDs		A0A8C8KJZ9 P02489	A7LNJ1 Q8WUM9
PDB IDs		6T1R
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Eye Lens Lens Development In Camera-type Eye	Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Protein-containing Complex Intracellular Signaling Cassette Negative Regulation Of T-helper 1 Cell Differentiation Leukocyte Mediated Immunity Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Lymphocyte Mediated Immunity Interleukin-4 Receptor Activity Septin Cytoskeleton Polkadots Positive Regulation Of Lymphotoxin A Production Negative Regulation Of Mature B Cell Apoptotic Process Regulation Of Production Of Molecular Mediator Of Immune Response CBM Complex Positive Regulation Of Mast Cell Cytokine Production Tubulin Complex Assembly Response To UV-A Lens Fiber Cell Morphogenesis Embryonic Camera-type Eye Morphogenesis Lens Morphogenesis In Camera-type Eye Rap Protein Signal Transduction Nerve Growth Factor Signaling Pathway Positive Regulation Of Lymphocyte Activation Positive Regulation Of Immune Effector Process Positive Regulation Of Cell-cell Adhesion T-helper 2 Cell Differentiation Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of T-helper 1 Type Immune Response Interleukin-4-mediated Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Adaptive Immune Response T-helper 1 Cell Differentiation Immune Effector Process Positive Regulation Of T-helper 2 Cell Differentiation Regulation Of T Cell Activation Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of Cell Activation Positive Regulation Of Mast Cell Degranulation Production Of Molecular Mediator Involved In Inflammatory Response Positive Regulation Of Myoblast Fusion MAP Kinase Activity Negative Regulation Of B Cell Apoptotic Process Kinase Activator Activity Antifungal Innate Immune Response CARD Domain Binding B Cell Apoptotic Process Protein Kinase B Binding General Transcription Initiation Factor Binding
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