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SMAD9 and FN1
Number of citations of the paper that reports this interaction (PMID
15231748
)
65
Data Source:
HPRD
(two hybrid)
SMAD9
FN1
Gene Name
SMAD family member 9
fibronectin 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Intracellular
Nucleus
Nucleoplasm
Transcription Factor Complex
Cytoplasm
Cytosol
Extracellular Region
Fibrinogen Complex
Basal Lamina
Extracellular Space
Endoplasmic Reticulum-Golgi Intermediate Compartment
Apical Plasma Membrane
Extracellular Matrix
Platelet Alpha Granule Lumen
Extracellular Vesicular Exosome
Blood Microparticle
Molecular Function
DNA Binding
Sequence-specific DNA Binding Transcription Factor Activity
Protein Binding
Transforming Growth Factor Beta Receptor, Pathway-specific Cytoplasmic Mediator Activity
Metal Ion Binding
Protease Binding
Integrin Binding
Protein Binding
Collagen Binding
Heparin Binding
Peptidase Activator Activity
Biological Process
Ureteric Bud Development
Response To Hypoxia
Mullerian Duct Regression
Transcription, DNA-templated
Protein Phosphorylation
Transforming Growth Factor Beta Receptor Signaling Pathway
BMP Signaling Pathway
Midbrain Development
Hindbrain Development
Intracellular Signal Transduction
Positive Regulation Of Cell Differentiation
Positive Regulation Of Transcription, DNA-templated
Cartilage Development
Bone Development
Cellular Response To Organic Cyclic Compound
Angiogenesis
Platelet Degranulation
Acute-phase Response
Cell-substrate Junction Assembly
Cell Adhesion
Calcium-independent Cell-matrix Adhesion
Blood Coagulation
Regulation Of Cell Shape
Response To Wounding
Positive Regulation Of Peptidase Activity
Peptide Cross-linking
Extracellular Matrix Disassembly
Platelet Activation
Extracellular Matrix Organization
Integrin Activation
Substrate Adhesion-dependent Cell Spreading
Endodermal Cell Differentiation
Positive Regulation Of Axon Extension
Leukocyte Migration
Pathways
Signaling by BMP
Elastic fibre formation
p130Cas linkage to MAPK signaling for integrins
Integrin alphaIIb beta3 signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
Non-integrin membrane-ECM interactions
Platelet degranulation
Platelet Aggregation (Plug Formation)
Degradation of the extracellular matrix
Cell surface interactions at the vascular wall
Molecules associated with elastic fibres
Syndecan interactions
ECM proteoglycans
Fibronectin matrix formation
Response to elevated platelet cytosolic Ca2+
Integrin cell surface interactions
Platelet activation, signaling and aggregation
Drugs
Ocriplasmin
Diseases
GWAS
Protein-Protein Interactions
117 interactors:
ABTB1
ACTB
ACVR1
AFF1
AP2A1
ARHGAP9
ARID1B
ARNT
ASB2
ASH2L
BAZ1A
BTG2
C10orf2
CAMSAP1
CEP135
CHPF
CLPB
CPXM2
CSH1
CSH2
CTR9
CXXC5
CYP11A1
DIAPH3
DKK1
DNAJA3
DNAJC7
DST
DSTN
E4F1
EIF3C
EIF3E
EIF3F
ERVV-1
EVC2
EXPH5
FLI1
FN1
FTL
GRN
HEY1
HEYL
HUWE1
KDM1A
KDM6A
KIAA0226
KMT2D
LEMD3
LMO4
LNPEP
LRP5
MAN1A2
MAN1C1
MAN2B1
MBD1
MCM3AP
METAP1
MGAT1
MTMR10
MTMR11
NAGK
OTUB1
PABPC4
PAPPA
PELP1
PHKA2
PIR
PKP2
PLEC
PNPLA2
PPARD
PPP2R5E
PRMT6
PSAP
PSMD8
QARS
RANBP9
RFX1
RMND5A
RNF123
RRBP1
SECISBP2
SF3B1
SIL1
SMAD2
SMAD3
SMAD4
SMG1
SNRNP70
SPTBN1
STAG1
SVEP1
TBCD
TERF1
TINAGL1
TMEM57
TOB1
TRIM29
TRIP12
TTC37
UBA6
UBE3A
UBQLN1
UBQLN4
UNC45A
VCPIP1
VPS8
XAB2
YWHAQ
ZEB2
ZNF484
ZNF557
ZNF587
ZNF587B
ZNF592
ZNF83
ZSCAN4
96 interactors:
ADAMTS4
AMBP
APCS
ATXN10
ATXN7
C1QA
CD44
CDKN2A
COL13A1
COL1A1
COL1A2
COL2A1
COL4A1
COL4A2
COL4A3
COL4A4
COL4A5
COL4A6
COL6A2
COL7A1
COMP
CRP
CTSD
CXCL12
DCN
DUSP10
EGFR
F13A1
FAM86B3P
FASLG
FBLN1
FBLN2
FST
FSTL3
GALNT6
GRB2
GSN
HGF
HRG
HSPG2
IGFBP3
IGFBP5
ITGA3
ITGA4
ITGA5
ITGA8
ITGB1
ITGB3
ITGB6
ITGB7
KLK3
KPNA2
LACRT
LGALS3BP
LPA
LRG1
LTBP1
MAG
MATN2
MEP1A
MEP1B
MIA
MMP9
MYOC
NOV
NR0B2
NT5E
PELI2
PKD1
PLAT
PLG
PRELP
PRPF40A
RARA
RBL1
REG3A
RPS6KA5
SCGB1A1
SDC2
SKIL
SMAD4
SMAD9
SPARC
STAT5A
TAB1
TAB2
TAC1
TGFBI
TGM2
THBS1
TMPRSS6
TNC
TNFRSF11B
TSHR
UBQLN1
VHL
Entrez ID
4093
2335
HPRD ID
04484
00626
Ensembl ID
ENSG00000120693
ENSG00000115414
Uniprot IDs
O15198
P02751
Q6MZF4
Q6MZM7
Q6N084
Q9UQS6
PDB IDs
1E88
1E8B
1FBR
1FNA
1FNF
1FNH
1J8K
1O9A
1OWW
1Q38
1QGB
1QO6
1TTF
1TTG
2CG6
2CG7
2CK2
2CKU
2EC3
2FN2
2FNB
2GEE
2H41
2H45
2HA1
2OCF
2RKY
2RKZ
2RL0
3CAL
3EJH
3GXE
3M7P
3MQL
3R8Q
3T1W
3ZRZ
4GH7
4JE4
4JEG
Enriched GO Terms of Interacting Partners
?
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Gene Expression
Cellular Metabolic Process
Transcription, DNA-templated
Biosynthetic Process
RNA Metabolic Process
RNA Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Regulation Of Metabolic Process
Cellular Process
Cellular Protein Metabolic Process
Protein Metabolic Process
Regulation Of Gene Expression
Nucleobase-containing Compound Metabolic Process
Gastrulation
Anterior/posterior Pattern Specification
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Positive Regulation Of Gene Expression
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Protein Metabolic Process
Positive Regulation Of Transcription, DNA-templated
Negative Regulation Of Gene Expression
Developmental Process
Cellular Nitrogen Compound Metabolic Process
Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Multicellular Organismal Development
Atrioventricular Valve Morphogenesis
Endoderm Development
Nitrogen Compound Metabolic Process
Formation Of Primary Germ Layer
Cell Differentiation
Atrioventricular Valve Development
Regulation Of Transcription From RNA Polymerase II Promoter
Anatomical Structure Development
Transcription From RNA Polymerase II Promoter
Organ Development
Negative Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Metabolic Process
Embryo Development
Negative Regulation Of RNA Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
SMAD Protein Complex Assembly
Posttranscriptional Regulation Of Gene Expression
Negative Regulation Of Transcription, DNA-templated
Pattern Specification Process
Extracellular Matrix Organization
Extracellular Structure Organization
Extracellular Matrix Disassembly
Developmental Process
Multicellular Organismal Development
Anatomical Structure Morphogenesis
System Development
Anatomical Structure Development
Collagen Catabolic Process
Response To Stimulus
Response To External Stimulus
Collagen Metabolic Process
Multicellular Organismal Macromolecule Metabolic Process
Locomotion
Multicellular Organismal Metabolic Process
Cell Differentiation
Wound Healing
Tissue Development
Response To Wounding
Axon Guidance
Response To Growth Factor
Response To Organic Substance
Organ Development
Response To Stress
Cellular Response To Stimulus
Cell Morphogenesis Involved In Differentiation
Movement Of Cell Or Subcellular Component
Neurogenesis
Generation Of Neurons
Chemotaxis
Regulation Of Cell Adhesion
Cell Adhesion
Axon Development
Blood Coagulation
Hemostasis
Regulation Of Body Fluid Levels
Axonogenesis
Cell Projection Organization
Cell Morphogenesis
Cardiovascular System Development
Nervous System Development
Neuron Projection Development
Skeletal System Development
Cell Morphogenesis Involved In Neuron Differentiation
Anatomical Structure Formation Involved In Morphogenesis
Neuron Development
Regulation Of Locomotion
Organ Morphogenesis
Cell Communication
Neuron Projection Morphogenesis
Tagcloud
?
2q33
2q34
artificial
bcg
brazilian
exon
il8
il8r
il8ra
il8rb
ity
leishmaniasis
leprosy
linkage
lod
lsh
nramp
pedigrees
proline
pseudogene
q35
q37
segregating
sh3
synteny
tnp1
typed
vil1
visceral
Tagcloud (Difference)
?
2q33
2q34
artificial
bcg
brazilian
exon
il8
il8r
il8ra
il8rb
ity
leishmaniasis
leprosy
linkage
lod
lsh
nramp
pedigrees
proline
pseudogene
q35
q37
segregating
sh3
synteny
tnp1
typed
vil1
visceral
Tagcloud (Intersection)
?