FN1 and COL9A1

Number of citations of the paper that reports this interaction (PubMedID 21768108)
61

Data Source:
BioGRID (two hybrid, pull down)

		FN1	COL9A1
Description		fibronectin 1	collagen type IX alpha 1 chain
Image
GO Annotations	Cellular Component	Extracellular Region Fibrinogen Complex Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Plasma Membrane Apical Plasma Membrane Extracellular Matrix Platelet Alpha Granule Lumen Extracellular Exosome Blood Microparticle	Extracellular Region Collagen Trimer Collagen Type IX Trimer Endoplasmic Reticulum Lumen Extracellular Matrix
	Molecular Function	Protease Binding Signaling Receptor Binding Integrin Binding Extracellular Matrix Structural Constituent Protein Binding Collagen Binding Heparin Binding Peptidase Activator Activity Identical Protein Binding Proteoglycan Binding Receptor Ligand Activity	Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Carbohydrate Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Angiogenesis Regulation Of Protein Phosphorylation Acute-phase Response Cell-substrate Junction Assembly Cell Adhesion Cell-matrix Adhesion Calcium-independent Cell-matrix Adhesion Integrin-mediated Signaling Pathway Nervous System Development Heart Development Positive Regulation Of Cell Population Proliferation Regulation Of Cell Shape Response To Wounding Positive Regulation Of Gene Expression Response To Muscle Activity Integrin Activation Substrate Adhesion-dependent Cell Spreading Endodermal Cell Differentiation Wound Healing Endothelial Cell Migration Positive Regulation Of Axon Extension Positive Regulation Of Fibroblast Proliferation Biological Process Involved In Interaction With Symbiont Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Transforming Growth Factor Beta Production Blood Coagulation, Fibrin Clot Formation Negative Regulation Of Monocyte Activation Neural Crest Cell Migration Involved In Autonomic Nervous System Development Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate	Animal Organ Morphogenesis
Pathways		Platelet degranulation Degradation of the extracellular matrix Degradation of the extracellular matrix Fibronectin matrix formation Cell surface interactions at the vascular wall Molecules associated with elastic fibres Integrin cell surface interactions Syndecan interactions Non-integrin membrane-ECM interactions ECM proteoglycans Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) MAP2K and MAPK activation Interleukin-4 and Interleukin-13 signaling Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF MET activates PTK2 signaling Post-translational protein phosphorylation GPER1 signaling Attachment of bacteria to epithelial cells Signaling downstream of RAS mutants Signaling by RAF1 mutants ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Developmental Lineage of Pancreatic Ductal Cells	Collagen degradation Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions ECM proteoglycans NCAM1 interactions Collagen chain trimerization
Drugs		Zinc Lanoteplase Ocriplasmin Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Cholesterol, total ( 26780889) Coronary artery disease ( 33020668 32469254 29212778 28714974) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Diastolic blood pressure ( 30578418) Iron status biomarkers (ferritin levels) ( 33536631) LDL cholesterol ( 24097068) LDL cholesterol levels ( 28334899 32203549) Lymphocyte count ( 32888494) Monocyte count ( 32888494) Myocardial infarction ( 33532862) Negative urgency ( 30718321) Pulse pressure ( 30578418 28135244 27841878) Systolic blood pressure ( 30578418 27841878) Total cholesterol levels ( 28334899) White blood cell count ( 32888494)
Interacting Genes		111 interacting genes: ADAMTS4 AMBP ANOS1 APCS ATXN10 ATXN7 C1QA CCN3 CD44 CDKN2A COL13A1 COL1A1 COL1A2 COL2A1 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 COL6A2 COL7A1 COL9A1 COMP CRP CTSD CXCL12 DCN DSCR9 DUSP10 EGFR F13A1 FAM86B3P FASLG FBLN1 FBLN2 FST FSTL3 GALNT6 GRB2 GSN HGF HOXA1 HRG HSP90AA1 HSPG2 IGFBP3 IGFBP5 ITGA2B ITGA3 ITGA4 ITGA5 ITGA8 ITGB1 ITGB3 ITGB6 ITGB7 KLK3 KPNA2 LACRT LGALS3BP LPA LRG1 LTBP1 MAG MATN2 MEP1A MEP1B MIA MMP9 MTDH MTNR1A MYOC NR0B2 NT5E PELI2 PKD1 PLAT PLG PRELP PRPF40A RARA RBL1 REG3A RPS6KA5 RSPH1 SCGB1A1 SDC2 SGCA SH3GLB1 SKIL SMAD4 SMAD9 SPARC STAT5A TAB1 TAB2 TAC1 TGFBI TGM2 THBS1 TIMD4 TLR4 TMPRSS6 TNC TNFRSF11B TSHR TTN UBQLN1 VEGFA VHL	4 interacting genes: CFTR COMP FN1 MAG
Entrez ID		2335	1297
HPRD ID		00626	00367
Ensembl ID		ENSG00000115414	ENSG00000112280
Uniprot IDs		B7ZLE5 P02751 Q9UQS6	A0A804HIB6 P20849
PDB IDs		1E88 1E8B 1FBR 1FNA 1FNF 1FNH 1J8K 1O9A 1OWW 1Q38 1QGB 1QO6 1TTF 1TTG 2CG6 2CG7 2CK2 2CKU 2EC3 2FN2 2FNB 2GEE 2H41 2H45 2HA1 2MNU 2N1K 2OCF 2RKY 2RKZ 2RL0 3CAL 3EJH 3GXE 3M7P 3MQL 3R8Q 3T1W 3ZRZ 4GH7 4JE4 4JEG 4LXO 4MMX 4MMY 4MMZ 4PZ5 5DC0 5DC4 5DC9 5DFT 5J6Z 5J7C 5M0A 5N47 5N48 6HNF 6MFA 6MSV 6NAJ 6XAX 6XAY 7NWL 8PEQ	2UUR 5CTD 5CTI 5CVA 5CVB
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Extracellular Region Extracellular Space Extracellular Matrix Structural Constituent Extracellular Matrix Structural Constituent Conferring Tensile Strength Fibronectin Binding Extracellular Matrix Organization Extracellular Structure Organization Basement Membrane Collagen Trimer Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Integrin Binding Cell Adhesion Endoplasmic Reticulum Lumen Cell Surface Developmental Process Negative Regulation Of Multicellular Organismal Process Collagen Type IV Trimer Integrin Complex Signal Transduction Negative Regulation Of Developmental Process Regulation Of Multicellular Organismal Process Response To Growth Factor Cell-matrix Adhesion Regulation Of Cell Adhesion Extracellular Matrix Binding Anatomical Structure Morphogenesis Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Regulation Of Vasculature Development Cell-cell Adhesion Positive Regulation Of Cell Migration Regulation Of Cell Migration Positive Regulation Of Cell Motility Regulation Of Developmental Process Regulation Of Multicellular Organismal Development Positive Regulation Of Locomotion Regulation Of Apoptotic Process Collagen-activated Signaling Pathway Regulation Of Angiogenesis Regulation Of Cell Motility Collagen Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Cell-substrate Adhesion Cell Adhesion Mediated By Integrin Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Programmed Cell Death Regulation Of Cell Population Proliferation Regulation Of Locomotion Integrin-mediated Signaling Pathway	Proteoglycan Binding Vesicle Docking Involved In Exocytosis Regulation Of Developmental Process Regulation Of Developmental Growth Regulation Of Multicellular Organismal Process Vesicle Docking Collagen Binding Regulation Of Cell Growth Positive Regulation Of Developmental Process Regulation Of Multicellular Organismal Development Organelle Localization By Membrane Tethering Regulation Of Axon Extension Membrane Docking Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Protease Binding Regulation Of Growth Extracellular Matrix Structural Constituent Regulation Of Nervous System Process Positive Regulation Of Anion Channel Activity Mesaxon Positive Regulation Of Monoatomic Anion Transport Heparin Binding Integrin Binding Positive Regulation Of Cell Growth Negative Regulation Of Monocyte Activation Regulation Of Axonogenesis Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Ganglioside GT1b Binding Positive Regulation Of Developmental Growth Regulation Of Exocytosis Positive Regulation Of Enamel Mineralization Anatomical Structure Formation Involved In Morphogenesis Cell Adhesion Tendon Development Cartilage Homeostasis Calcium-independent Cell-matrix Adhesion Regulation Of Anatomical Structure Morphogenesis Compact Myelin Nervous System Process Transepithelial Water Transport Response To Wounding Myelin Sheath Adaxonal Region Acrosomal Vesicle Exocytosis Positive Regulation Of Tooth Mineralization Cellular Component Assembly Positive Regulation Of Neurogenesis Neural Crest Cell Migration Involved In Autonomic Nervous System Development Central Nervous System Myelin Formation
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