FN1 and TMPRSS6

Number of citations of the paper that reports this interaction (PMID 12149247)
44

Data Source:
HPRD (in vitro)

		FN1	TMPRSS6
Gene Name		fibronectin 1	transmembrane protease, serine 6
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Fibrinogen Complex Basal Lamina Extracellular Space Endoplasmic Reticulum-Golgi Intermediate Compartment Apical Plasma Membrane Extracellular Matrix Platelet Alpha Granule Lumen Extracellular Vesicular Exosome Blood Microparticle	Plasma Membrane Integral Component Of Membrane
	Molecular Function	Protease Binding Integrin Binding Protein Binding Collagen Binding Heparin Binding Peptidase Activator Activity	Serine-type Endopeptidase Activity Protein Binding
	Biological Process	Angiogenesis Platelet Degranulation Acute-phase Response Cell-substrate Junction Assembly Cell Adhesion Calcium-independent Cell-matrix Adhesion Blood Coagulation Regulation Of Cell Shape Response To Wounding Positive Regulation Of Peptidase Activity Peptide Cross-linking Extracellular Matrix Disassembly Platelet Activation Extracellular Matrix Organization Integrin Activation Substrate Adhesion-dependent Cell Spreading Endodermal Cell Differentiation Positive Regulation Of Axon Extension Leukocyte Migration	Angiogenesis Proteolysis Extracellular Matrix Organization Negative Regulation Of BMP Signaling Pathway Intracellular Signal Transduction Fibrinolysis Iron Ion Homeostasis
Pathways		Elastic fibre formation p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling GRB2:SOS provides linkage to MAPK signaling for Integrins Non-integrin membrane-ECM interactions Platelet degranulation Platelet Aggregation (Plug Formation) Degradation of the extracellular matrix Cell surface interactions at the vascular wall Molecules associated with elastic fibres Syndecan interactions ECM proteoglycans Fibronectin matrix formation Response to elevated platelet cytosolic Ca2+ Integrin cell surface interactions Platelet activation, signaling and aggregation
Drugs		Ocriplasmin
Diseases
GWAS			Glycated hemoglobin levels ( 20858683) Hematocrit ( 19862010) Hematological and biochemical traits ( 20139978) Hematological parameters ( 19820697) Hematology traits ( 23263863 19853236) Hemoglobin ( 19820698 19862010) Hepcidin levels ( 21785125) Iron levels ( 19880490 21208937) Iron status biomarkers ( 21149283 19820699 19084217) Mean corpuscular hemoglobin ( 23263863 20139978 19862010) Mean corpuscular hemoglobin concentration ( 23263863 20139978) Mean corpuscular volume ( 23263863 20139978 19862010) Red blood cell traits ( 20927387 23222517)
Protein-Protein Interactions		96 interactors: ADAMTS4 AMBP APCS ATXN10 ATXN7 C1QA CD44 CDKN2A COL13A1 COL1A1 COL1A2 COL2A1 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 COL6A2 COL7A1 COMP CRP CTSD CXCL12 DCN DUSP10 EGFR F13A1 FAM86B3P FASLG FBLN1 FBLN2 FST FSTL3 GALNT6 GRB2 GSN HGF HRG HSPG2 IGFBP3 IGFBP5 ITGA3 ITGA4 ITGA5 ITGA8 ITGB1 ITGB3 ITGB6 ITGB7 KLK3 KPNA2 LACRT LGALS3BP LPA LRG1 LTBP1 MAG MATN2 MEP1A MEP1B MIA MMP9 MYOC NOV NR0B2 NT5E PELI2 PKD1 PLAT PLG PRELP PRPF40A RARA RBL1 REG3A RPS6KA5 SCGB1A1 SDC2 SKIL SMAD4 SMAD9 SPARC STAT5A TAB1 TAB2 TAC1 TGFBI TGM2 THBS1 TMPRSS6 TNC TNFRSF11B TSHR UBQLN1 VHL	3 interactors: COL1A1 FN1 LAMA1
Entrez ID		2335	164656
HPRD ID		00626	10270
Ensembl ID		ENSG00000115414	ENSG00000187045
Uniprot IDs		P02751 Q6MZF4 Q6MZM7 Q6N084 Q9UQS6	Q8IU80
PDB IDs		1E88 1E8B 1FBR 1FNA 1FNF 1FNH 1J8K 1O9A 1OWW 1Q38 1QGB 1QO6 1TTF 1TTG 2CG6 2CG7 2CK2 2CKU 2EC3 2FN2 2FNB 2GEE 2H41 2H45 2HA1 2OCF 2RKY 2RKZ 2RL0 3CAL 3EJH 3GXE 3M7P 3MQL 3R8Q 3T1W 3ZRZ 4GH7 4JE4 4JEG
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Developmental Process Multicellular Organismal Development Anatomical Structure Morphogenesis System Development Anatomical Structure Development Collagen Catabolic Process Response To Stimulus Response To External Stimulus Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Locomotion Multicellular Organismal Metabolic Process Cell Differentiation Wound Healing Tissue Development Response To Wounding Axon Guidance Response To Growth Factor Response To Organic Substance Organ Development Response To Stress Cellular Response To Stimulus Cell Morphogenesis Involved In Differentiation Movement Of Cell Or Subcellular Component Neurogenesis Generation Of Neurons Chemotaxis Regulation Of Cell Adhesion Cell Adhesion Axon Development Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Axonogenesis Cell Projection Organization Cell Morphogenesis Cardiovascular System Development Nervous System Development Neuron Projection Development Skeletal System Development Cell Morphogenesis Involved In Neuron Differentiation Anatomical Structure Formation Involved In Morphogenesis Neuron Development Regulation Of Locomotion Organ Morphogenesis Cell Communication Neuron Projection Morphogenesis	Extracellular Matrix Organization Extracellular Structure Organization Blood Vessel Development Vasculature Development Extracellular Matrix Disassembly Cardiovascular System Development Cellular Response To Fluoride Positive Regulation Of Cell Morphogenesis Involved In Differentiation Locomotion Platelet Activation Tooth Eruption Response To Fluoride Movement Of Cell Or Subcellular Component Leukocyte Migration Tissue Development Calcium-independent Cell-matrix Adhesion Retinal Blood Vessel Morphogenesis Cellular Response To Vitamin E Establishment Of Epithelial Cell Apical/basal Polarity Establishment Of Apical/basal Cell Polarity Polarized Epithelial Cell Differentiation Blood Coagulation Blood Vessel Morphogenesis Hemostasis Anatomical Structure Morphogenesis Regulation Of Cell Morphogenesis Establishment Of Monopolar Cell Polarity Intramembranous Ossification Tooth Mineralization Positive Regulation Of Cell Development Bone Trabecula Formation Protein Heterotrimerization Integrin Activation Retina Vasculature Morphogenesis In Camera-type Eye Collagen Biosynthetic Process Regulation Of Body Fluid Levels Regulation Of Cell Migration Wound Healing Regulation Of Cell Adhesion Regulation Of Cell Motility Establishment Of Epithelial Cell Polarity Bone Trabecula Morphogenesis Regulation Of Locomotion Cell Activation Response To Vitamin E Regulation Of Cellular Component Movement Response To Wounding Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Cell Morphogenesis Involved In Differentiation Retina Vasculature Development In Camera-type Eye
Tagcloud ?		2q33 2q34 artificial bcg brazilian exon il8 il8r il8ra il8rb ity leishmaniasis leprosy linkage lod lsh nramp pedigrees proline pseudogene q35 q37 segregating sh3 synteny tnp1 typed vil1 visceral	addressed africa allele anaemia breastfeeding comparatively falciparum ferritin haematological haemoglobin hb household id income odds outweigh plasmodium preventable rs855791 rural rwanda rwandan saharan southern substantially tended thalassaemia uncommon verified
Tagcloud (Difference) ?		2q33 2q34 artificial bcg brazilian exon il8 il8r il8ra il8rb ity leishmaniasis leprosy linkage lod lsh nramp pedigrees proline pseudogene q35 q37 segregating sh3 synteny tnp1 typed vil1 visceral	addressed africa allele anaemia breastfeeding comparatively falciparum ferritin haematological haemoglobin hb household id income odds outweigh plasmodium preventable rs855791 rural rwanda rwandan saharan southern substantially tended thalassaemia uncommon verified
Tagcloud (Intersection) ?