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SMAD9 and HUWE1
Number of citations of the paper that reports this interaction (PMID
15231748
)
65
Data Source:
HPRD
(two hybrid)
SMAD9
HUWE1
Gene Name
SMAD family member 9
HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Intracellular
Nucleus
Nucleoplasm
Transcription Factor Complex
Cytoplasm
Cytosol
Nucleus
Nucleoplasm
Cytoplasm
Membrane
Extracellular Vesicular Exosome
Molecular Function
DNA Binding
Sequence-specific DNA Binding Transcription Factor Activity
Protein Binding
Transforming Growth Factor Beta Receptor, Pathway-specific Cytoplasmic Mediator Activity
Metal Ion Binding
DNA Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Ligase Activity
Poly(A) RNA Binding
Biological Process
Ureteric Bud Development
Response To Hypoxia
Mullerian Duct Regression
Transcription, DNA-templated
Protein Phosphorylation
Transforming Growth Factor Beta Receptor Signaling Pathway
BMP Signaling Pathway
Midbrain Development
Hindbrain Development
Intracellular Signal Transduction
Positive Regulation Of Cell Differentiation
Positive Regulation Of Transcription, DNA-templated
Cartilage Development
Bone Development
Cellular Response To Organic Cyclic Compound
Protein Polyubiquitination
Base-excision Repair
Protein Monoubiquitination
Histone Ubiquitination
Cell Differentiation
Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Pathways
Signaling by BMP
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions
117 interactors:
ABTB1
ACTB
ACVR1
AFF1
AP2A1
ARHGAP9
ARID1B
ARNT
ASB2
ASH2L
BAZ1A
BTG2
C10orf2
CAMSAP1
CEP135
CHPF
CLPB
CPXM2
CSH1
CSH2
CTR9
CXXC5
CYP11A1
DIAPH3
DKK1
DNAJA3
DNAJC7
DST
DSTN
E4F1
EIF3C
EIF3E
EIF3F
ERVV-1
EVC2
EXPH5
FLI1
FN1
FTL
GRN
HEY1
HEYL
HUWE1
KDM1A
KDM6A
KIAA0226
KMT2D
LEMD3
LMO4
LNPEP
LRP5
MAN1A2
MAN1C1
MAN2B1
MBD1
MCM3AP
METAP1
MGAT1
MTMR10
MTMR11
NAGK
OTUB1
PABPC4
PAPPA
PELP1
PHKA2
PIR
PKP2
PLEC
PNPLA2
PPARD
PPP2R5E
PRMT6
PSAP
PSMD8
QARS
RANBP9
RFX1
RMND5A
RNF123
RRBP1
SECISBP2
SF3B1
SIL1
SMAD2
SMAD3
SMAD4
SMG1
SNRNP70
SPTBN1
STAG1
SVEP1
TBCD
TERF1
TINAGL1
TMEM57
TOB1
TRIM29
TRIP12
TTC37
UBA6
UBE3A
UBQLN1
UBQLN4
UNC45A
VCPIP1
VPS8
XAB2
YWHAQ
ZEB2
ZNF484
ZNF557
ZNF587
ZNF587B
ZNF592
ZNF83
ZSCAN4
20 interactors:
ABL1
CALM1
CCL1
CDKN2A
HDAC2
LAPTM5
MCL1
MYC
PIAS2
POLB
RNF11
SMAD2
SMAD9
TP53
UBE2D1
UBE2D2
UBE2D3
UBE2G1
UBE2L3
USP4
Entrez ID
4093
10075
HPRD ID
04484
06608
Ensembl ID
ENSG00000120693
ENSG00000086758
Uniprot IDs
O15198
Q7Z6Z7
PDB IDs
2EKK
3G1N
3H1D
Enriched GO Terms of Interacting Partners
?
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Gene Expression
Cellular Metabolic Process
Transcription, DNA-templated
Biosynthetic Process
RNA Metabolic Process
RNA Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Regulation Of Metabolic Process
Cellular Process
Cellular Protein Metabolic Process
Protein Metabolic Process
Regulation Of Gene Expression
Nucleobase-containing Compound Metabolic Process
Gastrulation
Anterior/posterior Pattern Specification
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Positive Regulation Of Gene Expression
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Protein Metabolic Process
Positive Regulation Of Transcription, DNA-templated
Negative Regulation Of Gene Expression
Developmental Process
Cellular Nitrogen Compound Metabolic Process
Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Multicellular Organismal Development
Atrioventricular Valve Morphogenesis
Endoderm Development
Nitrogen Compound Metabolic Process
Formation Of Primary Germ Layer
Cell Differentiation
Atrioventricular Valve Development
Regulation Of Transcription From RNA Polymerase II Promoter
Anatomical Structure Development
Transcription From RNA Polymerase II Promoter
Organ Development
Negative Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Metabolic Process
Embryo Development
Negative Regulation Of RNA Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
SMAD Protein Complex Assembly
Posttranscriptional Regulation Of Gene Expression
Negative Regulation Of Transcription, DNA-templated
Pattern Specification Process
Transforming Growth Factor Beta Receptor Signaling Pathway
Protein Polyubiquitination
Cellular Response To Transforming Growth Factor Beta Stimulus
Response To Transforming Growth Factor Beta
Cellular Response To Growth Factor Stimulus
Response To Growth Factor
Enzyme Linked Receptor Protein Signaling Pathway
Protein Modification By Small Protein Conjugation
Protein K48-linked Ubiquitination
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Cellular Response To Stress
Response To Organic Substance
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Cellular Protein Modification Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Protein Ubiquitination
Protein Catabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Protein Ubiquitination
Signal Transduction
Cellular Response To Organic Substance
Regulation Of Ubiquitin-protein Transferase Activity
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Negative Regulation Of Cell Cycle
Cellular Response To Hypoxia
Response To Abiotic Stimulus
Cellular Response To Decreased Oxygen Levels
Positive Regulation Of Cellular Metabolic Process
Negative Regulation Of Protein Ubiquitination
Positive Regulation Of Cellular Protein Metabolic Process
Cellular Response To Stimulus
Signaling
Cellular Response To Oxygen Levels
Negative Regulation Of Cellular Metabolic Process
Cell Communication
Response To Stress
Positive Regulation Of Protein Metabolic Process
Regulation Of Response To DNA Damage Stimulus
Response To Hypoxia
Cellular Macromolecule Catabolic Process
Transcription, DNA-templated
Cellular Protein Metabolic Process
Cell Cycle Arrest
Catabolic Process
Regulation Of Cell Cycle
RNA Biosynthetic Process
Intracellular Signal Transduction
Tagcloud
?
attractive
bicyclic
biol
catalyze
chem
cys
displacement
druggable
e2
e3
freund
heclin
hect
heinis
hek293
huge
kills
ligase
ligases
makes
mule
nat
phage
proven
rutherford
smurf2
thioesters
winter
wwp1
Tagcloud (Difference)
?
attractive
bicyclic
biol
catalyze
chem
cys
displacement
druggable
e2
e3
freund
heclin
hect
heinis
hek293
huge
kills
ligase
ligases
makes
mule
nat
phage
proven
rutherford
smurf2
thioesters
winter
wwp1
Tagcloud (Intersection)
?