FN1 and NT5E

Number of citations of the paper that reports this interaction (PMID 10470109)
9

Data Source:
HPRD (in vivo)

		FN1	NT5E
Gene Name		fibronectin 1	5-nucleotidase, ecto (CD73)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Fibrinogen Complex Basal Lamina Extracellular Space Endoplasmic Reticulum-Golgi Intermediate Compartment Apical Plasma Membrane Extracellular Matrix Platelet Alpha Granule Lumen Extracellular Vesicular Exosome Blood Microparticle	Cytoplasm Plasma Membrane Cell Surface Membrane Anchored Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Protease Binding Integrin Binding Protein Binding Collagen Binding Heparin Binding Peptidase Activator Activity	Nucleotide Binding 5'-nucleotidase Activity Metal Ion Binding
	Biological Process	Angiogenesis Platelet Degranulation Acute-phase Response Cell-substrate Junction Assembly Cell Adhesion Calcium-independent Cell-matrix Adhesion Blood Coagulation Regulation Of Cell Shape Response To Wounding Positive Regulation Of Peptidase Activity Peptide Cross-linking Extracellular Matrix Disassembly Platelet Activation Extracellular Matrix Organization Integrin Activation Substrate Adhesion-dependent Cell Spreading Endodermal Cell Differentiation Positive Regulation Of Axon Extension Leukocyte Migration	Purine Nucleobase Metabolic Process Purine Nucleotide Catabolic Process AMP Catabolic Process Pyrimidine Nucleobase Metabolic Process DNA Metabolic Process Dephosphorylation Small Molecule Metabolic Process Adenosine Biosynthetic Process Pyrimidine Nucleoside Catabolic Process Negative Regulation Of Inflammatory Response Nucleobase-containing Small Molecule Metabolic Process
Pathways		Elastic fibre formation p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling GRB2:SOS provides linkage to MAPK signaling for Integrins Non-integrin membrane-ECM interactions Platelet degranulation Platelet Aggregation (Plug Formation) Degradation of the extracellular matrix Cell surface interactions at the vascular wall Molecules associated with elastic fibres Syndecan interactions ECM proteoglycans Fibronectin matrix formation Response to elevated platelet cytosolic Ca2+ Integrin cell surface interactions Platelet activation, signaling and aggregation	Purine catabolism Pyrimidine catabolism Purine metabolism Pyrimidine metabolism Metabolism of nucleotides
Drugs		Ocriplasmin	Pentoxifylline
Diseases
GWAS			Metabolic traits ( 21886157)
Protein-Protein Interactions		96 interactors: ADAMTS4 AMBP APCS ATXN10 ATXN7 C1QA CD44 CDKN2A COL13A1 COL1A1 COL1A2 COL2A1 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 COL6A2 COL7A1 COMP CRP CTSD CXCL12 DCN DUSP10 EGFR F13A1 FAM86B3P FASLG FBLN1 FBLN2 FST FSTL3 GALNT6 GRB2 GSN HGF HRG HSPG2 IGFBP3 IGFBP5 ITGA3 ITGA4 ITGA5 ITGA8 ITGB1 ITGB3 ITGB6 ITGB7 KLK3 KPNA2 LACRT LGALS3BP LPA LRG1 LTBP1 MAG MATN2 MEP1A MEP1B MIA MMP9 MYOC NOV NR0B2 NT5E PELI2 PKD1 PLAT PLG PRELP PRPF40A RARA RBL1 REG3A RPS6KA5 SCGB1A1 SDC2 SKIL SMAD4 SMAD9 SPARC STAT5A TAB1 TAB2 TAC1 TGFBI TGM2 THBS1 TMPRSS6 TNC TNFRSF11B TSHR UBQLN1 VHL	4 interactors: ACTB AFF1 FN1 LAMA1
Entrez ID		2335	4907
HPRD ID		00626	00552
Ensembl ID		ENSG00000115414	ENSG00000135318
Uniprot IDs		P02751 Q6MZF4 Q6MZM7 Q6N084 Q9UQS6	P21589 Q6NZX3
PDB IDs		1E88 1E8B 1FBR 1FNA 1FNF 1FNH 1J8K 1O9A 1OWW 1Q38 1QGB 1QO6 1TTF 1TTG 2CG6 2CG7 2CK2 2CKU 2EC3 2FN2 2FNB 2GEE 2H41 2H45 2HA1 2OCF 2RKY 2RKZ 2RL0 3CAL 3EJH 3GXE 3M7P 3MQL 3R8Q 3T1W 3ZRZ 4GH7 4JE4 4JEG	4H1S 4H1Y 4H2B 4H2F 4H2G 4H2I
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Developmental Process Multicellular Organismal Development Anatomical Structure Morphogenesis System Development Anatomical Structure Development Collagen Catabolic Process Response To Stimulus Response To External Stimulus Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Locomotion Multicellular Organismal Metabolic Process Cell Differentiation Wound Healing Tissue Development Response To Wounding Axon Guidance Response To Growth Factor Response To Organic Substance Organ Development Response To Stress Cellular Response To Stimulus Cell Morphogenesis Involved In Differentiation Movement Of Cell Or Subcellular Component Neurogenesis Generation Of Neurons Chemotaxis Regulation Of Cell Adhesion Cell Adhesion Axon Development Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Axonogenesis Cell Projection Organization Cell Morphogenesis Cardiovascular System Development Nervous System Development Neuron Projection Development Skeletal System Development Cell Morphogenesis Involved In Neuron Differentiation Anatomical Structure Formation Involved In Morphogenesis Neuron Development Regulation Of Locomotion Organ Morphogenesis Cell Communication Neuron Projection Morphogenesis	Cell Morphogenesis Involved In Differentiation Cell Morphogenesis Platelet Activation Cell Junction Assembly Cell Adhesion Locomotion Calcium-independent Cell-matrix Adhesion Retinal Blood Vessel Morphogenesis Establishment Of Epithelial Cell Apical/basal Polarity Movement Of Cell Or Subcellular Component Generation Of Neurons Establishment Of Apical/basal Cell Polarity Polarized Epithelial Cell Differentiation Neurogenesis Extracellular Matrix Organization Extracellular Structure Organization Axon Guidance Establishment Of Monopolar Cell Polarity Cell Development Blood Coagulation Blood Vessel Morphogenesis Hemostasis Integrin Activation Retina Vasculature Morphogenesis In Camera-type Eye Blood Vessel Development Axonogenesis Establishment Of Epithelial Cell Polarity Vasculature Development Axon Development Nervous System Development Regulation Of Body Fluid Levels Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Cell Morphogenesis Involved In Neuron Differentiation Wound Healing Chemotaxis Retina Vasculature Development In Camera-type Eye Anatomical Structure Morphogenesis Morphogenesis Of A Polarized Epithelium Neuron Projection Morphogenesis Establishment Or Maintenance Of Apical/basal Cell Polarity Cell Activation Response To Wounding Branching Involved In Salivary Gland Morphogenesis Substantia Nigra Development Endodermal Cell Differentiation Platelet Aggregation Acute-phase Response Neuron Projection Development Positive Regulation Of Axon Extension Cell Projection Morphogenesis
Tagcloud ?		2q33 2q34 artificial bcg brazilian exon il8 il8r il8ra il8rb ity leishmaniasis leprosy linkage lod lsh nramp pedigrees proline pseudogene q35 q37 segregating sh3 synteny tnp1 typed vil1 visceral	amphiregulin areg betacellulin btc calgb cd73 cetuximab chemo dusp4 epgn epigen epiregulin erbb3 erbb4 ereg folfiri folfox formalin hbegf her3 her4 implicate kras mcrc modeled multiplicative pfs phlda1 tgfa
Tagcloud (Difference) ?		2q33 2q34 artificial bcg brazilian exon il8 il8r il8ra il8rb ity leishmaniasis leprosy linkage lod lsh nramp pedigrees proline pseudogene q35 q37 segregating sh3 synteny tnp1 typed vil1 visceral	amphiregulin areg betacellulin btc calgb cd73 cetuximab chemo dusp4 epgn epigen epiregulin erbb3 erbb4 ereg folfiri folfox formalin hbegf her3 her4 implicate kras mcrc modeled multiplicative pfs phlda1 tgfa
Tagcloud (Intersection) ?