FN1 and MIA

Number of citations of the paper that reports this interaction (PMID 11157741)
9

Data Source:
HPRD (in vivo)

		FN1	MIA
Gene Name		fibronectin 1	melanoma inhibitory activity
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Fibrinogen Complex Basal Lamina Extracellular Space Endoplasmic Reticulum-Golgi Intermediate Compartment Apical Plasma Membrane Extracellular Matrix Platelet Alpha Granule Lumen Extracellular Vesicular Exosome Blood Microparticle	Extracellular Space
	Molecular Function	Protease Binding Integrin Binding Protein Binding Collagen Binding Heparin Binding Peptidase Activator Activity	Growth Factor Activity
	Biological Process	Angiogenesis Platelet Degranulation Acute-phase Response Cell-substrate Junction Assembly Cell Adhesion Calcium-independent Cell-matrix Adhesion Blood Coagulation Regulation Of Cell Shape Response To Wounding Positive Regulation Of Peptidase Activity Peptide Cross-linking Extracellular Matrix Disassembly Platelet Activation Extracellular Matrix Organization Integrin Activation Substrate Adhesion-dependent Cell Spreading Endodermal Cell Differentiation Positive Regulation Of Axon Extension Leukocyte Migration	Cell Proliferation
Pathways		Elastic fibre formation p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling GRB2:SOS provides linkage to MAPK signaling for Integrins Non-integrin membrane-ECM interactions Platelet degranulation Platelet Aggregation (Plug Formation) Degradation of the extracellular matrix Cell surface interactions at the vascular wall Molecules associated with elastic fibres Syndecan interactions ECM proteoglycans Fibronectin matrix formation Response to elevated platelet cytosolic Ca2+ Integrin cell surface interactions Platelet activation, signaling and aggregation
Drugs		Ocriplasmin
Diseases
GWAS			Kawasaki disease ( 22446962)
Protein-Protein Interactions		96 interactors: ADAMTS4 AMBP APCS ATXN10 ATXN7 C1QA CD44 CDKN2A COL13A1 COL1A1 COL1A2 COL2A1 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 COL6A2 COL7A1 COMP CRP CTSD CXCL12 DCN DUSP10 EGFR F13A1 FAM86B3P FASLG FBLN1 FBLN2 FST FSTL3 GALNT6 GRB2 GSN HGF HRG HSPG2 IGFBP3 IGFBP5 ITGA3 ITGA4 ITGA5 ITGA8 ITGB1 ITGB3 ITGB6 ITGB7 KLK3 KPNA2 LACRT LGALS3BP LPA LRG1 LTBP1 MAG MATN2 MEP1A MEP1B MIA MMP9 MYOC NOV NR0B2 NT5E PELI2 PKD1 PLAT PLG PRELP PRPF40A RARA RBL1 REG3A RPS6KA5 SCGB1A1 SDC2 SKIL SMAD4 SMAD9 SPARC STAT5A TAB1 TAB2 TAC1 TGFBI TGM2 THBS1 TMPRSS6 TNC TNFRSF11B TSHR UBQLN1 VHL	2 interactors: FASLG FN1
Entrez ID		2335	8190
HPRD ID		00626	03216
Ensembl ID		ENSG00000115414	ENSG00000261857
Uniprot IDs		P02751 Q6MZF4 Q6MZM7 Q6N084 Q9UQS6	Q16674
PDB IDs		1E88 1E8B 1FBR 1FNA 1FNF 1FNH 1J8K 1O9A 1OWW 1Q38 1QGB 1QO6 1TTF 1TTG 2CG6 2CG7 2CK2 2CKU 2EC3 2FN2 2FNB 2GEE 2H41 2H45 2HA1 2OCF 2RKY 2RKZ 2RL0 3CAL 3EJH 3GXE 3M7P 3MQL 3R8Q 3T1W 3ZRZ 4GH7 4JE4 4JEG	1HJD 1I1J 1K0X
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Developmental Process Multicellular Organismal Development Anatomical Structure Morphogenesis System Development Anatomical Structure Development Collagen Catabolic Process Response To Stimulus Response To External Stimulus Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Locomotion Multicellular Organismal Metabolic Process Cell Differentiation Wound Healing Tissue Development Response To Wounding Axon Guidance Response To Growth Factor Response To Organic Substance Organ Development Response To Stress Cellular Response To Stimulus Cell Morphogenesis Involved In Differentiation Movement Of Cell Or Subcellular Component Neurogenesis Generation Of Neurons Chemotaxis Regulation Of Cell Adhesion Cell Adhesion Axon Development Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Axonogenesis Cell Projection Organization Cell Morphogenesis Cardiovascular System Development Nervous System Development Neuron Projection Development Skeletal System Development Cell Morphogenesis Involved In Neuron Differentiation Anatomical Structure Formation Involved In Morphogenesis Neuron Development Regulation Of Locomotion Organ Morphogenesis Cell Communication Neuron Projection Morphogenesis	Positive Regulation Of Peptidase Activity Positive Regulation Of Proteolysis Endosomal Lumen Acidification Regulation Of Peptidase Activity Retinal Cell Programmed Cell Death Calcium-independent Cell-matrix Adhesion Necroptotic Signaling Pathway Cellular Chloride Ion Homeostasis Inflammatory Cell Apoptotic Process Chloride Ion Homeostasis Regulation Of Proteolysis Positive Regulation Of Endothelial Cell Apoptotic Process Integrin Activation T Cell Apoptotic Process Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Intracellular PH Reduction PH Reduction Positive Regulation Of Hydrolase Activity Positive Regulation Of ERBB Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Endosome Organization Necroptotic Process Positive Regulation Of Protein Metabolic Process Regulation Of Endothelial Cell Apoptotic Process Endodermal Cell Differentiation Acute-phase Response Developmental Programmed Cell Death Positive Regulation Of Axon Extension Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Substrate Adhesion-dependent Cell Spreading Regulation Of Intracellular PH Programmed Necrotic Cell Death Anion Homeostasis Peptide Cross-linking Regulation Of Cellular PH Necrotic Cell Death Positive Regulation Of Catalytic Activity Cell-substrate Junction Assembly Endoderm Formation Positive Regulation Of Neuron Apoptotic Process Platelet Degranulation Regulation Of Axon Extension Cell Development Regulation Of PH Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Acute Inflammatory Response Positive Regulation Of Neuron Death Positive Regulation Of Axonogenesis Regulation Of ERBB Signaling Pathway Negative Regulation Of Angiogenesis
Tagcloud ?		2q33 2q34 artificial bcg brazilian exon il8 il8r il8ra il8rb ity leishmaniasis leprosy linkage lod lsh nramp pedigrees proline pseudogene q35 q37 segregating sh3 synteny tnp1 typed vil1 visceral	agar autocrine cloned colonies differed escape formed hypothesize independence insensitive kinetics loop media neutralization nude nutrient paca panc potentiated proliferate quiescence rapidly representative seeded soft tgf transferrin tumorigenic tumorigenicity
Tagcloud (Difference) ?		2q33 2q34 artificial bcg brazilian exon il8 il8r il8ra il8rb ity leishmaniasis leprosy linkage lod lsh nramp pedigrees proline pseudogene q35 q37 segregating sh3 synteny tnp1 typed vil1 visceral	agar autocrine cloned colonies differed escape formed hypothesize independence insensitive kinetics loop media neutralization nude nutrient paca panc potentiated proliferate quiescence rapidly representative seeded soft tgf transferrin tumorigenic tumorigenicity
Tagcloud (Intersection) ?