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SMAD9 and PAPPA
Number of citations of the paper that reports this interaction (PMID
15231748
)
65
Data Source:
HPRD
(two hybrid)
SMAD9
PAPPA
Gene Name
SMAD family member 9
pregnancy-associated plasma protein A, pappalysin 1
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Intracellular
Nucleus
Nucleoplasm
Transcription Factor Complex
Cytoplasm
Cytosol
Extracellular Region
Membrane
Molecular Function
DNA Binding
Sequence-specific DNA Binding Transcription Factor Activity
Protein Binding
Transforming Growth Factor Beta Receptor, Pathway-specific Cytoplasmic Mediator Activity
Metal Ion Binding
Metalloendopeptidase Activity
Metallopeptidase Activity
Zinc Ion Binding
Biological Process
Ureteric Bud Development
Response To Hypoxia
Mullerian Duct Regression
Transcription, DNA-templated
Protein Phosphorylation
Transforming Growth Factor Beta Receptor Signaling Pathway
BMP Signaling Pathway
Midbrain Development
Hindbrain Development
Intracellular Signal Transduction
Positive Regulation Of Cell Differentiation
Positive Regulation Of Transcription, DNA-templated
Cartilage Development
Bone Development
Cellular Response To Organic Cyclic Compound
Proteolysis
Female Pregnancy
Cell Differentiation
Cellular Protein Metabolic Process
Pathways
Signaling by BMP
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Drugs
Diseases
GWAS
Height (
20881960
18391950
)
Protein-Protein Interactions
117 interactors:
ABTB1
ACTB
ACVR1
AFF1
AP2A1
ARHGAP9
ARID1B
ARNT
ASB2
ASH2L
BAZ1A
BTG2
C10orf2
CAMSAP1
CEP135
CHPF
CLPB
CPXM2
CSH1
CSH2
CTR9
CXXC5
CYP11A1
DIAPH3
DKK1
DNAJA3
DNAJC7
DST
DSTN
E4F1
EIF3C
EIF3E
EIF3F
ERVV-1
EVC2
EXPH5
FLI1
FN1
FTL
GRN
HEY1
HEYL
HUWE1
KDM1A
KDM6A
KIAA0226
KMT2D
LEMD3
LMO4
LNPEP
LRP5
MAN1A2
MAN1C1
MAN2B1
MBD1
MCM3AP
METAP1
MGAT1
MTMR10
MTMR11
NAGK
OTUB1
PABPC4
PAPPA
PELP1
PHKA2
PIR
PKP2
PLEC
PNPLA2
PPARD
PPP2R5E
PRMT6
PSAP
PSMD8
QARS
RANBP9
RFX1
RMND5A
RNF123
RRBP1
SECISBP2
SF3B1
SIL1
SMAD2
SMAD3
SMAD4
SMG1
SNRNP70
SPTBN1
STAG1
SVEP1
TBCD
TERF1
TINAGL1
TMEM57
TOB1
TRIM29
TRIP12
TTC37
UBA6
UBE3A
UBQLN1
UBQLN4
UNC45A
VCPIP1
VPS8
XAB2
YWHAQ
ZEB2
ZNF484
ZNF557
ZNF587
ZNF587B
ZNF592
ZNF83
ZSCAN4
10 interactors:
ATF7IP
C3
IGFBP4
PLG
PRG2
SKIL
SMAD2
SMAD3
SMAD9
TNNI3
Entrez ID
4093
5069
HPRD ID
04484
01448
Ensembl ID
ENSG00000120693
ENSG00000182752
Uniprot IDs
O15198
Q13219
Q7Z613
Q86YM8
Q8IWT8
PDB IDs
Enriched GO Terms of Interacting Partners
?
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Gene Expression
Cellular Metabolic Process
Transcription, DNA-templated
Biosynthetic Process
RNA Metabolic Process
RNA Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Regulation Of Metabolic Process
Cellular Process
Cellular Protein Metabolic Process
Protein Metabolic Process
Regulation Of Gene Expression
Nucleobase-containing Compound Metabolic Process
Gastrulation
Anterior/posterior Pattern Specification
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Positive Regulation Of Gene Expression
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Protein Metabolic Process
Positive Regulation Of Transcription, DNA-templated
Negative Regulation Of Gene Expression
Developmental Process
Cellular Nitrogen Compound Metabolic Process
Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Multicellular Organismal Development
Atrioventricular Valve Morphogenesis
Endoderm Development
Nitrogen Compound Metabolic Process
Formation Of Primary Germ Layer
Cell Differentiation
Atrioventricular Valve Development
Regulation Of Transcription From RNA Polymerase II Promoter
Anatomical Structure Development
Transcription From RNA Polymerase II Promoter
Organ Development
Negative Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Metabolic Process
Embryo Development
Negative Regulation Of RNA Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
SMAD Protein Complex Assembly
Posttranscriptional Regulation Of Gene Expression
Negative Regulation Of Transcription, DNA-templated
Pattern Specification Process
Transforming Growth Factor Beta Receptor Signaling Pathway
Cellular Response To Transforming Growth Factor Beta Stimulus
Response To Transforming Growth Factor Beta
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Primary MiRNA Processing
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
SMAD Protein Complex Assembly
Paraxial Mesoderm Morphogenesis
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Negative Regulation Of Cellular Response To Growth Factor Stimulus
Ureteric Bud Development
Mesonephric Tubule Development
Mesonephric Epithelium Development
Mesonephros Development
Nodal Signaling Pathway
Embryonic Foregut Morphogenesis
Tissue Development
Foregut Morphogenesis
Paraxial Mesoderm Development
Kidney Epithelium Development
Positive Regulation Of Cell Morphogenesis Involved In Differentiation
Production Of MiRNAs Involved In Gene Silencing By MiRNA
In Utero Embryonic Development
Transcription Initiation From RNA Polymerase II Promoter
Pericardium Development
Regulation Of Cellular Component Organization
Regulation Of Cellular Response To Growth Factor Stimulus
Skeletal System Development
Signal Transduction Involved In Regulation Of Gene Expression
Cellular Response To Growth Factor Stimulus
Lens Fiber Cell Differentiation
Response To Growth Factor
Activin Receptor Signaling Pathway
Positive Regulation Of Epithelial To Mesenchymal Transition
Regulation Of Gene Expression, Epigenetic
Positive Regulation Of Signal Transduction
Gene Silencing By MiRNA
DNA-templated Transcription, Initiation
Cellular Response To DsRNA
Posttranscriptional Gene Silencing
Developmental Growth
SMAD Protein Signal Transduction
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Stem Cell Differentiation
Chordate Embryonic Development
Embryo Development Ending In Birth Or Egg Hatching
Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of Cellular Metabolic Process
Kidney Development
Tagcloud
?
alleviate
altering
alternating
american
capillaries
ccl2
closer
coat
concave
convex
dawley
diepoxide
endometrium
eosin
follicles
ginseng
glands
hematoxylin
nell1
ovarian
pla2g4a
pof
premature
sprague
stc2
uterine
vcd
vinylcyclohexene
visible
Tagcloud (Difference)
?
alleviate
altering
alternating
american
capillaries
ccl2
closer
coat
concave
convex
dawley
diepoxide
endometrium
eosin
follicles
ginseng
glands
hematoxylin
nell1
ovarian
pla2g4a
pof
premature
sprague
stc2
uterine
vcd
vinylcyclohexene
visible
Tagcloud (Intersection)
?