SMAD9 and PHKA2

Number of citations of the paper that reports this interaction (PMID 15231748)
65

Data Source:
HPRD (two hybrid)

		SMAD9	PHKA2
Gene Name		SMAD family member 9	phosphorylase kinase, alpha 2 (liver)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol	Cytosol Plasma Membrane Phosphorylase Kinase Complex
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transforming Growth Factor Beta Receptor, Pathway-specific Cytoplasmic Mediator Activity Metal Ion Binding	Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Phosphorylase Kinase Activity Calmodulin Binding
	Biological Process	Ureteric Bud Development Response To Hypoxia Mullerian Duct Regression Transcription, DNA-templated Protein Phosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway BMP Signaling Pathway Midbrain Development Hindbrain Development Intracellular Signal Transduction Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription, DNA-templated Cartilage Development Bone Development Cellular Response To Organic Cyclic Compound	Carbohydrate Metabolic Process Glycogen Catabolic Process Glucose Metabolic Process Generation Of Precursor Metabolites And Energy Cellular Protein Modification Process Protein Phosphorylation Pathogenesis Small Molecule Metabolic Process
Pathways		Signaling by BMP	Glucose metabolism Glycogen breakdown (glycogenolysis) Myoclonic epilepsy of Lafora Glycogen storage diseases Metabolism of carbohydrates
Drugs
Diseases
GWAS
Protein-Protein Interactions		117 interactors: ABTB1 ACTB ACVR1 AFF1 AP2A1 ARHGAP9 ARID1B ARNT ASB2 ASH2L BAZ1A BTG2 C10orf2 CAMSAP1 CEP135 CHPF CLPB CPXM2 CSH1 CSH2 CTR9 CXXC5 CYP11A1 DIAPH3 DKK1 DNAJA3 DNAJC7 DST DSTN E4F1 EIF3C EIF3E EIF3F ERVV-1 EVC2 EXPH5 FLI1 FN1 FTL GRN HEY1 HEYL HUWE1 KDM1A KDM6A KIAA0226 KMT2D LEMD3 LMO4 LNPEP LRP5 MAN1A2 MAN1C1 MAN2B1 MBD1 MCM3AP METAP1 MGAT1 MTMR10 MTMR11 NAGK OTUB1 PABPC4 PAPPA PELP1 PHKA2 PIR PKP2 PLEC PNPLA2 PPARD PPP2R5E PRMT6 PSAP PSMD8 QARS RANBP9 RFX1 RMND5A RNF123 RRBP1 SECISBP2 SF3B1 SIL1 SMAD2 SMAD3 SMAD4 SMG1 SNRNP70 SPTBN1 STAG1 SVEP1 TBCD TERF1 TINAGL1 TMEM57 TOB1 TRIM29 TRIP12 TTC37 UBA6 UBE3A UBQLN1 UBQLN4 UNC45A VCPIP1 VPS8 XAB2 YWHAQ ZEB2 ZNF484 ZNF557 ZNF587 ZNF587B ZNF592 ZNF83 ZSCAN4	2 interactors: RAF1 SMAD9
Entrez ID		4093	5256
HPRD ID		04484	02380
Ensembl ID		ENSG00000120693	ENSG00000044446
Uniprot IDs		O15198	P46019
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Gene Expression Cellular Metabolic Process Transcription, DNA-templated Biosynthetic Process RNA Metabolic Process RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Cellular Process Cellular Protein Metabolic Process Protein Metabolic Process Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Gastrulation Anterior/posterior Pattern Specification Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Developmental Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Multicellular Organismal Development Atrioventricular Valve Morphogenesis Endoderm Development Nitrogen Compound Metabolic Process Formation Of Primary Germ Layer Cell Differentiation Atrioventricular Valve Development Regulation Of Transcription From RNA Polymerase II Promoter Anatomical Structure Development Transcription From RNA Polymerase II Promoter Organ Development Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Metabolic Process Embryo Development Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process SMAD Protein Complex Assembly Posttranscriptional Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Pattern Specification Process	Death-inducing Signaling Complex Assembly Response To Hypoxia Mullerian Duct Regression Cellular Response To Growth Factor Stimulus Response To Growth Factor Enzyme Linked Receptor Protein Signaling Pathway Anatomical Structure Regression Response To Abiotic Stimulus Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Activation Of Adenylate Cyclase Activity Positive Regulation Of Adenylate Cyclase Activity Protein Phosphorylation Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Positive Regulation Of Lyase Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Cell Differentiation Positive Regulation Of Cellular Biosynthetic Process Regulation Of Adenylate Cyclase Activity Positive Regulation Of CAMP Biosynthetic Process Activation Of MAPKK Activity Regulation Of Cyclase Activity Positive Regulation Of CAMP Metabolic Process Somatic Stem Cell Maintenance Phosphorylation Intracellular Signal Transduction Cellular Response To Organic Substance BMP Signaling Pathway Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Cyclic Nucleotide Metabolic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Midbrain Development Negative Regulation Of Cysteine-type Endopeptidase Activity Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Peptidyl-serine Phosphorylation Extrinsic Apoptotic Signaling Pathway
Tagcloud ?			3614c accompanying breakdown carrier cdna enzymatic examinations female glycogen gsd gsdixa hepatomegaly heterozygous inherited ixa leukocytes manifestation manifested p1205l preferential proband recessive repeatedly serial skewed storage suspected ultrasonographic xci
Tagcloud (Difference) ?			3614c accompanying breakdown carrier cdna enzymatic examinations female glycogen gsd gsdixa hepatomegaly heterozygous inherited ixa leukocytes manifestation manifested p1205l preferential proband recessive repeatedly serial skewed storage suspected ultrasonographic xci
Tagcloud (Intersection) ?