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FN1 and PLAT
Number of citations of the paper that reports this interaction (PubMedID
8360181
)
0
Data Source:
BioGRID
(pull down)
FN1
PLAT
Description
fibronectin 1
plasminogen activator, tissue type
Image
GO Annotations
Cellular Component
Extracellular Region
Fibrinogen Complex
Basement Membrane
Extracellular Space
Endoplasmic Reticulum Lumen
Endoplasmic Reticulum-Golgi Intermediate Compartment
Plasma Membrane
Apical Plasma Membrane
Extracellular Matrix
Platelet Alpha Granule Lumen
Extracellular Exosome
Blood Microparticle
Extracellular Region
Extracellular Space
Cytoplasm
Cell Surface
Secretory Granule
Extracellular Matrix
Apical Part Of Cell
Extracellular Exosome
Serine Protease Inhibitor Complex
Schaffer Collateral - CA1 Synapse
Glutamatergic Synapse
Molecular Function
Protease Binding
Signaling Receptor Binding
Integrin Binding
Extracellular Matrix Structural Constituent
Protein Binding
Collagen Binding
Heparin Binding
Peptidase Activator Activity
Identical Protein Binding
Proteoglycan Binding
Receptor Ligand Activity
Serine-type Endopeptidase Activity
Signaling Receptor Binding
Protein Binding
Peptidase Activity
Serine-type Peptidase Activity
Hydrolase Activity
Phosphoprotein Binding
Biological Process
Angiogenesis
Regulation Of Protein Phosphorylation
Acute-phase Response
Cell-substrate Junction Assembly
Cell Adhesion
Cell-matrix Adhesion
Calcium-independent Cell-matrix Adhesion
Integrin-mediated Signaling Pathway
Nervous System Development
Heart Development
Positive Regulation Of Cell Population Proliferation
Regulation Of Cell Shape
Response To Wounding
Positive Regulation Of Gene Expression
Response To Muscle Activity
Integrin Activation
Substrate Adhesion-dependent Cell Spreading
Endodermal Cell Differentiation
Wound Healing
Endothelial Cell Migration
Positive Regulation Of Axon Extension
Positive Regulation Of Fibroblast Proliferation
Biological Process Involved In Interaction With Symbiont
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of ERK1 And ERK2 Cascade
Negative Regulation Of Transforming Growth Factor Beta Production
Blood Coagulation, Fibrin Clot Formation
Negative Regulation Of Monocyte Activation
Neural Crest Cell Migration Involved In Autonomic Nervous System Development
Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate
Response To Hypoxia
Proteolysis
Blood Coagulation
Negative Regulation Of Plasminogen Activation
Smooth Muscle Cell Migration
Zymogen Activation
Plasminogen Activation
Protein Modification Process
Fibrinolysis
Negative Regulation Of Proteolysis
Platelet-derived Growth Factor Receptor Signaling Pathway
Negative Regulation Of Fibrinolysis
Prevention Of Polyspermy
Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission
Pathways
Platelet degranulation
Degradation of the extracellular matrix
Degradation of the extracellular matrix
Fibronectin matrix formation
Cell surface interactions at the vascular wall
Molecules associated with elastic fibres
Integrin cell surface interactions
Syndecan interactions
Non-integrin membrane-ECM interactions
ECM proteoglycans
Integrin signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
MAP2K and MAPK activation
Interleukin-4 and Interleukin-13 signaling
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF1 fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
MET activates PTK2 signaling
Post-translational protein phosphorylation
GPER1 signaling
Attachment of bacteria to epithelial cells
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
ALK mutants bind TKIs
Signaling by ALK fusions and activated point mutants
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Developmental Lineage of Pancreatic Ductal Cells
Signaling by PDGF
Dissolution of Fibrin Clot
Drugs
Zinc
Lanoteplase
Ocriplasmin
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Aminocaproic acid
Iloprost
Human C1-esterase inhibitor
5-(DIMETHYLAMINO)-2-NAPHTHALENESULFONIC ACID
Dexibuprofen
Conestat alfa
Diseases
GWAS
Apolipoprotein B levels (
32203549
)
Cholesterol, total (
26780889
)
Coronary artery disease (
33020668
32469254
29212778
28714974
)
Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) (
28714975
)
Diastolic blood pressure (
30578418
)
Iron status biomarkers (ferritin levels) (
33536631
)
LDL cholesterol (
24097068
)
LDL cholesterol levels (
28334899
32203549
)
Lymphocyte count (
32888494
)
Monocyte count (
32888494
)
Myocardial infarction (
33532862
)
Negative urgency (
30718321
)
Pulse pressure (
30578418
28135244
27841878
)
Systolic blood pressure (
30578418
27841878
)
Total cholesterol levels (
28334899
)
White blood cell count (
32888494
)
Blood protein levels (
30072576
)
Plasma plasminogen activator levels (
24578379
)
Systemic lupus erythematosus (
28714469
)
Interacting Genes
111 interacting genes:
ADAMTS4
AMBP
ANOS1
APCS
ATXN10
ATXN7
C1QA
CCN3
CD44
CDKN2A
COL13A1
COL1A1
COL1A2
COL2A1
COL4A1
COL4A2
COL4A3
COL4A4
COL4A5
COL4A6
COL6A2
COL7A1
COL9A1
COMP
CRP
CTSD
CXCL12
DCN
DSCR9
DUSP10
EGFR
F13A1
FAM86B3P
FASLG
FBLN1
FBLN2
FST
FSTL3
GALNT6
GRB2
GSN
HGF
HOXA1
HRG
HSP90AA1
HSPG2
IGFBP3
IGFBP5
ITGA2B
ITGA3
ITGA4
ITGA5
ITGA8
ITGB1
ITGB3
ITGB6
ITGB7
KLK3
KPNA2
LACRT
LGALS3BP
LPA
LRG1
LTBP1
MAG
MATN2
MEP1A
MEP1B
MIA
MMP9
MTDH
MTNR1A
MYOC
NR0B2
NT5E
PELI2
PKD1
PLAT
PLG
PRELP
PRPF40A
RARA
RBL1
REG3A
RPS6KA5
RSPH1
SCGB1A1
SDC2
SGCA
SH3GLB1
SKIL
SMAD4
SMAD9
SPARC
STAT5A
TAB1
TAB2
TAC1
TGFBI
TGM2
THBS1
TIMD4
TLR4
TMPRSS6
TNC
TNFRSF11B
TSHR
TTN
UBQLN1
VEGFA
VHL
28 interacting genes:
ANXA2
APP
CALR
CKAP4
CLEC3B
F10
FGA
FN1
GRIN1
HMGB1
KRT8
LAMA1
LAMA3
LRP1
LRP1B
MAPK1
MAPK3
MTDH
PDGFC
PLAU
PLG
SERPINA5
SERPINE1
SERPING1
SERPINI1
SNCA
SPARC
VDAC1
Entrez ID
2335
5327
HPRD ID
00626
01419
Ensembl ID
ENSG00000115414
ENSG00000104368
Uniprot IDs
B7ZLE5
P02751
Q9UQS6
B4DN26
P00750
PDB IDs
1E88
1E8B
1FBR
1FNA
1FNF
1FNH
1J8K
1O9A
1OWW
1Q38
1QGB
1QO6
1TTF
1TTG
2CG6
2CG7
2CK2
2CKU
2EC3
2FN2
2FNB
2GEE
2H41
2H45
2HA1
2MNU
2N1K
2OCF
2RKY
2RKZ
2RL0
3CAL
3EJH
3GXE
3M7P
3MQL
3R8Q
3T1W
3ZRZ
4GH7
4JE4
4JEG
4LXO
4MMX
4MMY
4MMZ
4PZ5
5DC0
5DC4
5DC9
5DFT
5J6Z
5J7C
5M0A
5N47
5N48
6HNF
6MFA
6MSV
6NAJ
6XAX
6XAY
7NWL
8PEQ
1A5H
1BDA
1PK2
1PML
1RTF
1TPG
1TPK
1TPM
1TPN
5BRR
5ZLZ
Enriched GO Terms of Interacting Partners
?
Extracellular Matrix
Extracellular Region
Extracellular Space
Extracellular Matrix Structural Constituent
Extracellular Matrix Structural Constituent Conferring Tensile Strength
Fibronectin Binding
Extracellular Matrix Organization
Extracellular Structure Organization
Basement Membrane
Collagen Trimer
Enzyme-linked Receptor Protein Signaling Pathway
Cell Surface Receptor Signaling Pathway
Integrin Binding
Cell Adhesion
Endoplasmic Reticulum Lumen
Cell Surface
Developmental Process
Negative Regulation Of Multicellular Organismal Process
Collagen Type IV Trimer
Integrin Complex
Signal Transduction
Negative Regulation Of Developmental Process
Regulation Of Multicellular Organismal Process
Response To Growth Factor
Cell-matrix Adhesion
Regulation Of Cell Adhesion
Extracellular Matrix Binding
Anatomical Structure Morphogenesis
Collagen-activated Tyrosine Kinase Receptor Signaling Pathway
Regulation Of Vasculature Development
Cell-cell Adhesion
Positive Regulation Of Cell Migration
Regulation Of Cell Migration
Positive Regulation Of Cell Motility
Regulation Of Developmental Process
Regulation Of Multicellular Organismal Development
Positive Regulation Of Locomotion
Regulation Of Apoptotic Process
Collagen-activated Signaling Pathway
Regulation Of Angiogenesis
Regulation Of Cell Motility
Collagen Binding
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Cell-substrate Adhesion
Cell Adhesion Mediated By Integrin
Regulation Of Cellular Response To Growth Factor Stimulus
Regulation Of Programmed Cell Death
Regulation Of Cell Population Proliferation
Regulation Of Locomotion
Integrin-mediated Signaling Pathway
Fibrinolysis
Extracellular Space
Regulation Of Locomotion
Regulation Of Cell Migration
Platelet Alpha Granule Lumen
Positive Regulation Of Cell Migration
Positive Regulation Of Cell Motility
Regulation Of Cell Motility
Extracellular Region
Positive Regulation Of Locomotion
Endoplasmic Reticulum Lumen
Negative Regulation Of Blood Coagulation
Extracellular Matrix
Negative Regulation Of Hemostasis
Negative Regulation Of Coagulation
Regulation Of Blood Coagulation
Negative Regulation Of Wound Healing
Regulation Of Hemostasis
Regulation Of Wound Healing
Serine-type Endopeptidase Inhibitor Activity
Regulation Of Plasminogen Activation
Positive Regulation Of Leukocyte Chemotaxis
Positive Regulation Of Mononuclear Cell Migration
Platelet Alpha Granule
Regulation Of Cell Adhesion
Cell Surface
Regulation Of Response To Wounding
Regulation Of Multicellular Organismal Process
Regulation Of Vesicle-mediated Transport
Regulation Of Protein Maturation
Positive Regulation Of Signaling
Extracellular Exosome
Positive Regulation Of Chemotaxis
Regulation Of Mononuclear Cell Migration
Positive Regulation Of Leukocyte Migration
Positive Regulation Of Endocytosis
Basement Membrane
Plasma Membrane
Negative Regulation Of Fibrinolysis
Regulation Of Body Fluid Levels
Positive Regulation Of Cell Communication
Blood Coagulation
Positive Regulation Of Cellular Component Organization
Coagulation
Protease Binding
Hemostasis
Peptidase Inhibitor Activity
Regulation Of Endocytosis
Negative Regulation Of Multicellular Organismal Process
Calcium Ion Binding
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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