FN1 and TSHR

Number of citations of the paper that reports this interaction (PMID 11981027)
3

Data Source:
HPRD (in vivo)

		FN1	TSHR
Gene Name		fibronectin 1	thyroid stimulating hormone receptor
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Fibrinogen Complex Basal Lamina Extracellular Space Endoplasmic Reticulum-Golgi Intermediate Compartment Apical Plasma Membrane Extracellular Matrix Platelet Alpha Granule Lumen Extracellular Vesicular Exosome Blood Microparticle	Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex
	Molecular Function	Protease Binding Integrin Binding Protein Binding Collagen Binding Heparin Binding Peptidase Activator Activity	Thyroid-stimulating Hormone Receptor Activity Protein Binding
	Biological Process	Angiogenesis Platelet Degranulation Acute-phase Response Cell-substrate Junction Assembly Cell Adhesion Calcium-independent Cell-matrix Adhesion Blood Coagulation Regulation Of Cell Shape Response To Wounding Positive Regulation Of Peptidase Activity Peptide Cross-linking Extracellular Matrix Disassembly Platelet Activation Extracellular Matrix Organization Integrin Activation Substrate Adhesion-dependent Cell Spreading Endodermal Cell Differentiation Positive Regulation Of Axon Extension Leukocyte Migration	G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell-cell Signaling Positive Regulation Of Cell Proliferation Thyroid-stimulating Hormone Signaling Pathway
Pathways		Elastic fibre formation p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling GRB2:SOS provides linkage to MAPK signaling for Integrins Non-integrin membrane-ECM interactions Platelet degranulation Platelet Aggregation (Plug Formation) Degradation of the extracellular matrix Cell surface interactions at the vascular wall Molecules associated with elastic fibres Syndecan interactions ECM proteoglycans Fibronectin matrix formation Response to elevated platelet cytosolic Ca2+ Integrin cell surface interactions Platelet activation, signaling and aggregation	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) Hormone ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs		Ocriplasmin	Thyrotropin Alfa
Diseases
GWAS			Graves' disease ( 21841780) Hair morphology ( 19896111) Optic disc size (rim) ( 20395239) Visceral fat ( 22589738)
Protein-Protein Interactions		96 interactors: ADAMTS4 AMBP APCS ATXN10 ATXN7 C1QA CD44 CDKN2A COL13A1 COL1A1 COL1A2 COL2A1 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 COL6A2 COL7A1 COMP CRP CTSD CXCL12 DCN DUSP10 EGFR F13A1 FAM86B3P FASLG FBLN1 FBLN2 FST FSTL3 GALNT6 GRB2 GSN HGF HRG HSPG2 IGFBP3 IGFBP5 ITGA3 ITGA4 ITGA5 ITGA8 ITGB1 ITGB3 ITGB6 ITGB7 KLK3 KPNA2 LACRT LGALS3BP LPA LRG1 LTBP1 MAG MATN2 MEP1A MEP1B MIA MMP9 MYOC NOV NR0B2 NT5E PELI2 PKD1 PLAT PLG PRELP PRPF40A RARA RBL1 REG3A RPS6KA5 SCGB1A1 SDC2 SKIL SMAD4 SMAD9 SPARC STAT5A TAB1 TAB2 TAC1 TGFBI TGM2 THBS1 TMPRSS6 TNC TNFRSF11B TSHR UBQLN1 VHL	24 interactors: ADRB2 CALR CANX FLNB FN1 GNA11 GNA12 GNA13 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ GNAS HSPA5 JAK1 JAK2 LHCGR PIK3R1 RABAC1 SCRIB STAT3 TSHB UBC
Entrez ID		2335	7253
HPRD ID		00626	04537
Ensembl ID		ENSG00000115414	ENSG00000165409
Uniprot IDs		P02751 Q6MZF4 Q6MZM7 Q6N084 Q9UQS6	F5GYU5 P16473
PDB IDs		1E88 1E8B 1FBR 1FNA 1FNF 1FNH 1J8K 1O9A 1OWW 1Q38 1QGB 1QO6 1TTF 1TTG 2CG6 2CG7 2CK2 2CKU 2EC3 2FN2 2FNB 2GEE 2H41 2H45 2HA1 2OCF 2RKY 2RKZ 2RL0 3CAL 3EJH 3GXE 3M7P 3MQL 3R8Q 3T1W 3ZRZ 4GH7 4JE4 4JEG	1XUM 2XWT 3G04
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Developmental Process Multicellular Organismal Development Anatomical Structure Morphogenesis System Development Anatomical Structure Development Collagen Catabolic Process Response To Stimulus Response To External Stimulus Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Locomotion Multicellular Organismal Metabolic Process Cell Differentiation Wound Healing Tissue Development Response To Wounding Axon Guidance Response To Growth Factor Response To Organic Substance Organ Development Response To Stress Cellular Response To Stimulus Cell Morphogenesis Involved In Differentiation Movement Of Cell Or Subcellular Component Neurogenesis Generation Of Neurons Chemotaxis Regulation Of Cell Adhesion Cell Adhesion Axon Development Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Axonogenesis Cell Projection Organization Cell Morphogenesis Cardiovascular System Development Nervous System Development Neuron Projection Development Skeletal System Development Cell Morphogenesis Involved In Neuron Differentiation Anatomical Structure Formation Involved In Morphogenesis Neuron Development Regulation Of Locomotion Organ Morphogenesis Cell Communication Neuron Projection Morphogenesis	G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Platelet Activation Blood Coagulation Hemostasis Wound Healing Response To Wounding Regulation Of Body Fluid Levels Signaling Cell Communication Response To Stress Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Cell Activation Signal Transduction Positive Regulation Of Catalytic Activity Regulation Of Catalytic Activity Response To Stimulus Regulation Of Adenylate Cyclase Activity Developmental Process Regulation Of Cyclase Activity Cellular Response To Stimulus Regulation Of CAMP Biosynthetic Process Dopamine Receptor Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of CAMP Metabolic Process Response To Organic Substance Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Hydrolase Activity Regulation Of Signal Transduction Regulation Of Kinase Activity Cellular Localization Anatomical Structure Development Establishment Of Localization In Cell Regulation Of Signaling Regulation Of Cell Migration Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Motility Growth Hormone Receptor Signaling Pathway Response To Hormone Cellular Response To Growth Hormone Stimulus Regulation Of Locomotion Regulation Of Cellular Component Movement Cell Differentiation Multicellular Organismal Development Activation Of Adenylate Cyclase Activity Response To Cytokine Regulation Of Cellular Process Cellular Response To Organic Substance
Tagcloud ?		2q33 2q34 artificial bcg brazilian exon il8 il8r il8ra il8rb ity leishmaniasis leprosy linkage lod lsh nramp pedigrees proline pseudogene q35 q37 segregating sh3 synteny tnp1 typed vil1 visceral	adenomas autonomous autonomy characterised constitutive disseminated evaluates f fdg focal focally gain goiters head hypermetabolism invoked iodine metabolism neck nodules pet radioiodine served simultaneous ten thyroid thyrotropin toxic twenty
Tagcloud (Difference) ?		2q33 2q34 artificial bcg brazilian exon il8 il8r il8ra il8rb ity leishmaniasis leprosy linkage lod lsh nramp pedigrees proline pseudogene q35 q37 segregating sh3 synteny tnp1 typed vil1 visceral	adenomas autonomous autonomy characterised constitutive disseminated evaluates f fdg focal focally gain goiters head hypermetabolism invoked iodine metabolism neck nodules pet radioiodine served simultaneous ten thyroid thyrotropin toxic twenty
Tagcloud (Intersection) ?