FN1 and THBS1

Number of citations of the paper that reports this interaction (PMID 11773026)
30

Data Source:
HPRD (in vitro)

		FN1	THBS1
Gene Name		fibronectin 1	thrombospondin 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Fibrinogen Complex Basal Lamina Extracellular Space Endoplasmic Reticulum-Golgi Intermediate Compartment Apical Plasma Membrane Extracellular Matrix Platelet Alpha Granule Lumen Extracellular Vesicular Exosome Blood Microparticle	Extracellular Region Fibrinogen Complex Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen External Side Of Plasma Membrane Cell Surface Sarcoplasmic Reticulum Secretory Granule Extracellular Matrix Platelet Alpha Granule Platelet Alpha Granule Lumen Extracellular Vesicular Exosome
	Molecular Function	Protease Binding Integrin Binding Protein Binding Collagen Binding Heparin Binding Peptidase Activator Activity	Phosphatidylserine Binding Glycoprotein Binding Fibronectin Binding Integrin Binding Calcium Ion Binding Protein Binding Heparin Binding Fibroblast Growth Factor Binding Low-density Lipoprotein Particle Binding Identical Protein Binding Laminin Binding Proteoglycan Binding Transforming Growth Factor Beta Binding Fibrinogen Binding Collagen V Binding
	Biological Process	Angiogenesis Platelet Degranulation Acute-phase Response Cell-substrate Junction Assembly Cell Adhesion Calcium-independent Cell-matrix Adhesion Blood Coagulation Regulation Of Cell Shape Response To Wounding Positive Regulation Of Peptidase Activity Peptide Cross-linking Extracellular Matrix Disassembly Platelet Activation Extracellular Matrix Organization Integrin Activation Substrate Adhesion-dependent Cell Spreading Endodermal Cell Differentiation Positive Regulation Of Axon Extension Leukocyte Migration	Activation Of MAPK Activity Response To Hypoxia Negative Regulation Of Endothelial Cell Proliferation Negative Regulation Of Cell-matrix Adhesion Sprouting Angiogenesis Chronic Inflammatory Response Platelet Degranulation Negative Regulation Of Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Negative Regulation Of Dendritic Cell Antigen Processing And Presentation Outflow Tract Morphogenesis Endocardial Cushion Development Growth Plate Cartilage Development Protein O-linked Glycosylation Immune Response Response To Unfolded Protein Cell Cycle Arrest Cell Adhesion Blood Coagulation Response To Mechanical Stimulus Response To Glucose Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Negative Regulation Of Nitric Oxide Mediated Signal Transduction Negative Regulation Of CGMP-mediated Signaling Negative Regulation Of Plasminogen Activation Positive Regulation Of Macrophage Chemotaxis Positive Regulation Of Fibroblast Migration Positive Regulation Of Cell-substrate Adhesion Cell Migration Negative Regulation Of Angiogenesis Peptide Cross-linking Platelet Activation Positive Regulation Of Blood Coagulation Extracellular Matrix Organization Positive Regulation Of Cell Migration Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of CGMP Metabolic Process Response To Magnesium Ion Response To Progesterone Negative Regulation Of Interleukin-12 Production Positive Regulation Of Transforming Growth Factor Beta1 Production Response To Testosterone Cellular Response To Heat Response To Endoplasmic Reticulum Stress Protein O-linked Fucosylation Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Phosphorylation Response To Drug Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Positive Regulation Of Macrophage Activation Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Engulfment Of Apoptotic Cell Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Translation Positive Regulation Of Angiogenesis Behavioral Response To Pain Positive Regulation Of Chemotaxis Response To Calcium Ion Negative Regulation Of Focal Adhesion Assembly Positive Regulation Of Protein Kinase B Signaling Negative Regulation Of Fibrinolysis Cellular Response To Tumor Necrosis Factor Cellular Response To Growth Factor Stimulus Cellular Response To Nitric Oxide Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Endothelial Cell Chemotaxis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Elastic fibre formation p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling GRB2:SOS provides linkage to MAPK signaling for Integrins Non-integrin membrane-ECM interactions Platelet degranulation Platelet Aggregation (Plug Formation) Degradation of the extracellular matrix Cell surface interactions at the vascular wall Molecules associated with elastic fibres Syndecan interactions ECM proteoglycans Fibronectin matrix formation Response to elevated platelet cytosolic Ca2+ Integrin cell surface interactions Platelet activation, signaling and aggregation	Signaling by PDGF Post-translational protein modification Non-integrin membrane-ECM interactions Platelet degranulation O-glycosylation of TSR domain-containing proteins O-linked glycosylation Syndecan interactions Response to elevated platelet cytosolic Ca2+ Integrin cell surface interactions Platelet activation, signaling and aggregation
Drugs		Ocriplasmin
Diseases
GWAS
Protein-Protein Interactions		96 interactors: ADAMTS4 AMBP APCS ATXN10 ATXN7 C1QA CD44 CDKN2A COL13A1 COL1A1 COL1A2 COL2A1 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 COL6A2 COL7A1 COMP CRP CTSD CXCL12 DCN DUSP10 EGFR F13A1 FAM86B3P FASLG FBLN1 FBLN2 FST FSTL3 GALNT6 GRB2 GSN HGF HRG HSPG2 IGFBP3 IGFBP5 ITGA3 ITGA4 ITGA5 ITGA8 ITGB1 ITGB3 ITGB6 ITGB7 KLK3 KPNA2 LACRT LGALS3BP LPA LRG1 LTBP1 MAG MATN2 MEP1A MEP1B MIA MMP9 MYOC NOV NR0B2 NT5E PELI2 PKD1 PLAT PLG PRELP PRPF40A RARA RBL1 REG3A RPS6KA5 SCGB1A1 SDC2 SKIL SMAD4 SMAD9 SPARC STAT5A TAB1 TAB2 TAC1 TGFBI TGM2 THBS1 TMPRSS6 TNC TNFRSF11B TSHR UBQLN1 VHL	39 interactors: CALCR CALR CD36 CD47 CFH COL1A1 COL2A1 COL3A1 COL4A1 COL5A1 COL7A1 CORO1A CTSG DCN DHFR ELANE F2 FGA FGF2 FN1 HRG IGFBP5 ITGB3 JAG1 KNG1 LAMB3 LRP1 LRP2 LRP5 MMP2 MMP9 PDGFB PLG SCARB2 SPARC TFPI TGFB1 TNFAIP6 TNFRSF11B
Entrez ID		2335	7057
HPRD ID		00626	01765
Ensembl ID		ENSG00000115414
Uniprot IDs		P02751 Q6MZF4 Q6MZM7 Q6N084 Q9UQS6	P07996
PDB IDs		1E88 1E8B 1FBR 1FNA 1FNF 1FNH 1J8K 1O9A 1OWW 1Q38 1QGB 1QO6 1TTF 1TTG 2CG6 2CG7 2CK2 2CKU 2EC3 2FN2 2FNB 2GEE 2H41 2H45 2HA1 2OCF 2RKY 2RKZ 2RL0 3CAL 3EJH 3GXE 3M7P 3MQL 3R8Q 3T1W 3ZRZ 4GH7 4JE4 4JEG	1LSL 1UX6 1Z78 1ZA4 2ERF 2ES3 2OUH 2OUJ 3R6B
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Developmental Process Multicellular Organismal Development Anatomical Structure Morphogenesis System Development Anatomical Structure Development Collagen Catabolic Process Response To Stimulus Response To External Stimulus Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Locomotion Multicellular Organismal Metabolic Process Cell Differentiation Wound Healing Tissue Development Response To Wounding Axon Guidance Response To Growth Factor Response To Organic Substance Organ Development Response To Stress Cellular Response To Stimulus Cell Morphogenesis Involved In Differentiation Movement Of Cell Or Subcellular Component Neurogenesis Generation Of Neurons Chemotaxis Regulation Of Cell Adhesion Cell Adhesion Axon Development Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Axonogenesis Cell Projection Organization Cell Morphogenesis Cardiovascular System Development Nervous System Development Neuron Projection Development Skeletal System Development Cell Morphogenesis Involved In Neuron Differentiation Anatomical Structure Formation Involved In Morphogenesis Neuron Development Regulation Of Locomotion Organ Morphogenesis Cell Communication Neuron Projection Morphogenesis	Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Wound Healing Platelet Activation Response To Wounding Platelet Degranulation Blood Coagulation Hemostasis Vesicle-mediated Transport Collagen Catabolic Process Regulation Of Locomotion Response To External Stimulus Collagen Metabolic Process Regulation Of Body Fluid Levels Cardiovascular System Development Regulation Of Cell Migration Multicellular Organismal Macromolecule Metabolic Process Locomotion Multicellular Organismal Metabolic Process Regulation Of Cell Motility Blood Vessel Development Vasculature Development Response To Stimulus Regulation Of Cellular Component Movement Tissue Development Response To Stress Leukocyte Migration Response To Organic Substance Movement Of Cell Or Subcellular Component Negative Regulation Of Wound Healing Endocytosis Cell Migration Regulation Of Wound Healing Cell Activation Blood Vessel Morphogenesis Cell Motility Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Anatomical Structure Morphogenesis Exocytosis Positive Regulation Of Cellular Component Movement Immune System Process Positive Regulation Of Locomotion Regulation Of Blood Coagulation Multicellular Organismal Development Negative Regulation Of Blood Coagulation Anatomical Structure Development Negative Regulation Of Coagulation System Development
Tagcloud ?		2q33 2q34 artificial bcg brazilian exon il8 il8r il8ra il8rb ity leishmaniasis leprosy linkage lod lsh nramp pedigrees proline pseudogene q35 q37 segregating sh3 synteny tnp1 typed vil1 visceral	bag1 bcl2l2 bctis ccna2 comprehend ctsb deregulations fgf1 fosl1 gabrp gsn hnepi id2 il6r itgb4 klf5 klk5 map2k7 microdissected ngfb ngfr ontological pappa plau scgb1d2 scgb2a1 serpinb5 serpine1 thbs2
Tagcloud (Difference) ?		2q33 2q34 artificial bcg brazilian exon il8 il8r il8ra il8rb ity leishmaniasis leprosy linkage lod lsh nramp pedigrees proline pseudogene q35 q37 segregating sh3 synteny tnp1 typed vil1 visceral	bag1 bcl2l2 bctis ccna2 comprehend ctsb deregulations fgf1 fosl1 gabrp gsn hnepi id2 il6r itgb4 klf5 klk5 map2k7 microdissected ngfb ngfr ontological pappa plau scgb1d2 scgb2a1 serpinb5 serpine1 thbs2
Tagcloud (Intersection) ?