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SMAD9 and HEYL
Number of citations of the paper that reports this interaction (PMID
15231748
)
65
Data Source:
HPRD
(two hybrid)
SMAD9
HEYL
Gene Name
SMAD family member 9
hes-related family bHLH transcription factor with YRPW motif-like
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Intracellular
Nucleus
Nucleoplasm
Transcription Factor Complex
Cytoplasm
Cytosol
Nucleus
Nucleoplasm
Cytoplasm
Molecular Function
DNA Binding
Sequence-specific DNA Binding Transcription Factor Activity
Protein Binding
Transforming Growth Factor Beta Receptor, Pathway-specific Cytoplasmic Mediator Activity
Metal Ion Binding
RNA Polymerase II Core Promoter Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Sequence-specific DNA Binding Transcription Factor Activity
Protein Binding Transcription Factor Activity
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription
RNA Polymerase II Transcription Corepressor Activity
Sequence-specific DNA Binding Transcription Factor Activity
Transcription Corepressor Activity
Protein Binding
Transcription Factor Binding
Microsatellite Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
AF-1 Domain Binding
Biological Process
Ureteric Bud Development
Response To Hypoxia
Mullerian Duct Regression
Transcription, DNA-templated
Protein Phosphorylation
Transforming Growth Factor Beta Receptor Signaling Pathway
BMP Signaling Pathway
Midbrain Development
Hindbrain Development
Intracellular Signal Transduction
Positive Regulation Of Cell Differentiation
Positive Regulation Of Transcription, DNA-templated
Cartilage Development
Bone Development
Cellular Response To Organic Cyclic Compound
Outflow Tract Morphogenesis
Atrioventricular Valve Morphogenesis
Pulmonary Valve Morphogenesis
Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Endocardial Cushion Morphogenesis
Cardiac Ventricle Morphogenesis
Transcription From RNA Polymerase II Promoter
Notch Signaling Pathway
Mesenchymal Cell Development
Glomerulus Development
Skeletal Muscle Cell Differentiation
Positive Regulation Of Neuron Differentiation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Cardiac Epithelial To Mesenchymal Transition
Ventricular Septum Morphogenesis
Negative Regulation Of Androgen Receptor Signaling Pathway
Cellular Response To BMP Stimulus
Proximal Tubule Development
Negative Regulation Of Androgen Receptor Activity
Pathways
Signaling by BMP
Signaling by NOTCH1 HD Domain Mutants in Cancer
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
Signaling by NOTCH
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
NOTCH1 Intracellular Domain Regulates Transcription
Signaling by NOTCH1
Signaling by NOTCH1 PEST Domain Mutants in Cancer
Signaling by NOTCH1 in Cancer
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Constitutive Signaling by NOTCH1 PEST Domain Mutants
FBXW7 Mutants and NOTCH1 in Cancer
Drugs
Diseases
GWAS
Red blood cell traits (
23222517
)
Protein-Protein Interactions
117 interactors:
ABTB1
ACTB
ACVR1
AFF1
AP2A1
ARHGAP9
ARID1B
ARNT
ASB2
ASH2L
BAZ1A
BTG2
C10orf2
CAMSAP1
CEP135
CHPF
CLPB
CPXM2
CSH1
CSH2
CTR9
CXXC5
CYP11A1
DIAPH3
DKK1
DNAJA3
DNAJC7
DST
DSTN
E4F1
EIF3C
EIF3E
EIF3F
ERVV-1
EVC2
EXPH5
FLI1
FN1
FTL
GRN
HEY1
HEYL
HUWE1
KDM1A
KDM6A
KIAA0226
KMT2D
LEMD3
LMO4
LNPEP
LRP5
MAN1A2
MAN1C1
MAN2B1
MBD1
MCM3AP
METAP1
MGAT1
MTMR10
MTMR11
NAGK
OTUB1
PABPC4
PAPPA
PELP1
PHKA2
PIR
PKP2
PLEC
PNPLA2
PPARD
PPP2R5E
PRMT6
PSAP
PSMD8
QARS
RANBP9
RFX1
RMND5A
RNF123
RRBP1
SECISBP2
SF3B1
SIL1
SMAD2
SMAD3
SMAD4
SMG1
SNRNP70
SPTBN1
STAG1
SVEP1
TBCD
TERF1
TINAGL1
TMEM57
TOB1
TRIM29
TRIP12
TTC37
UBA6
UBE3A
UBQLN1
UBQLN4
UNC45A
VCPIP1
VPS8
XAB2
YWHAQ
ZEB2
ZNF484
ZNF557
ZNF587
ZNF587B
ZNF592
ZNF83
ZSCAN4
18 interactors:
APP
ATF7IP
ATXN1
HAND1
HAND2
HIPK3
HTT
LAPTM5
MDFI
PPP1CA
RBPMS
RPGRIP1
SKIL
SMAD3
SMAD7
SMAD9
SP8
ZNF512B
Entrez ID
4093
26508
HPRD ID
04484
16419
Ensembl ID
ENSG00000120693
ENSG00000163909
Uniprot IDs
O15198
F5H3V9
Q9NQ87
PDB IDs
Enriched GO Terms of Interacting Partners
?
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Gene Expression
Cellular Metabolic Process
Transcription, DNA-templated
Biosynthetic Process
RNA Metabolic Process
RNA Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Regulation Of Metabolic Process
Cellular Process
Cellular Protein Metabolic Process
Protein Metabolic Process
Regulation Of Gene Expression
Nucleobase-containing Compound Metabolic Process
Gastrulation
Anterior/posterior Pattern Specification
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Positive Regulation Of Gene Expression
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Protein Metabolic Process
Positive Regulation Of Transcription, DNA-templated
Negative Regulation Of Gene Expression
Developmental Process
Cellular Nitrogen Compound Metabolic Process
Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Multicellular Organismal Development
Atrioventricular Valve Morphogenesis
Endoderm Development
Nitrogen Compound Metabolic Process
Formation Of Primary Germ Layer
Cell Differentiation
Atrioventricular Valve Development
Regulation Of Transcription From RNA Polymerase II Promoter
Anatomical Structure Development
Transcription From RNA Polymerase II Promoter
Organ Development
Negative Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Metabolic Process
Embryo Development
Negative Regulation Of RNA Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
SMAD Protein Complex Assembly
Posttranscriptional Regulation Of Gene Expression
Negative Regulation Of Transcription, DNA-templated
Pattern Specification Process
Regulation Of Gene Expression
Transcription, DNA-templated
RNA Biosynthetic Process
Anatomical Structure Morphogenesis
RNA Metabolic Process
Transforming Growth Factor Beta Receptor Signaling Pathway
Gene Expression
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Organ Development
Regulation Of Transcription From RNA Polymerase II Promoter
Cellular Response To Transforming Growth Factor Beta Stimulus
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Response To Transforming Growth Factor Beta
Heterocycle Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Tube Development
Epithelium Development
Negative Regulation Of Signal Transduction
Positive Regulation Of Gene Expression
Regulation Of Metabolic Process
Regulation Of Signal Transduction
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Pattern Specification Process
Negative Regulation Of Signaling
Regulation Of Binding
Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Cellular Macromolecule Biosynthetic Process
Negative Regulation Of Cellular Response To Growth Factor Stimulus
Macromolecule Biosynthetic Process
Tissue Development
Nitrogen Compound Metabolic Process
Nucleobase-containing Compound Metabolic Process
Regulation Of Signaling
Positive Regulation Of Transcription, DNA-templated
Multicellular Organismal Development
Cellular Aromatic Compound Metabolic Process
Biosynthetic Process
Cardiac Right Ventricle Formation
Anatomical Structure Development
Positive Regulation Of Cellular Metabolic Process
Organ Morphogenesis
Negative Regulation Of DNA Binding
Embryonic Morphogenesis
System Development
Tagcloud
?
bad
bromide
cancerous
dimethylthiazol
diphenyltetrazolium
egfp
eighty
expressional
hairy
hcc
hep
hypermethylation
inactivated
lentiviral
overexpress
p19
pheyl
preceded
qpcr
repressor
resected
ribose
shheyl
silence
sk
split
surgically
yrpw
Tagcloud (Difference)
?
bad
bromide
cancerous
dimethylthiazol
diphenyltetrazolium
egfp
eighty
expressional
hairy
hcc
hep
hypermethylation
inactivated
lentiviral
overexpress
p19
pheyl
preceded
qpcr
repressor
resected
ribose
shheyl
silence
sk
split
surgically
yrpw
Tagcloud (Intersection)
?