SMAD9 and KDM6A

Number of citations of the paper that reports this interaction (PMID 15231748)
65

Data Source:
HPRD (two hybrid)

		SMAD9	KDM6A
Gene Name		SMAD family member 9	lysine (K)-specific demethylase 6A
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol	Nucleus Nucleoplasm Histone Methyltransferase Complex
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transforming Growth Factor Beta Receptor, Pathway-specific Cytoplasmic Mediator Activity Metal Ion Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Identical Protein Binding Metal Ion Binding Dioxygenase Activity Histone Demethylase Activity (H3-K27 Specific)
	Biological Process	Ureteric Bud Development Response To Hypoxia Mullerian Duct Regression Transcription, DNA-templated Protein Phosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway BMP Signaling Pathway Midbrain Development Hindbrain Development Intracellular Signal Transduction Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription, DNA-templated Cartilage Development Bone Development Cellular Response To Organic Cyclic Compound	In Utero Embryonic Development Neural Tube Closure Heart Morphogenesis Respiratory System Process Chromatin Organization Regulation Of Gene Expression Somite Rostral/caudal Axis Specification Multicellular Organism Growth Mesodermal Cell Differentiation Notochord Morphogenesis Histone H3-K4 Methylation Oxidation-reduction Process Canonical Wnt Signaling Pathway Histone H3-K27 Demethylation
Pathways		Signaling by BMP	Chromatin modifying enzymes Chromatin organization HDMs demethylate histones
Drugs
Diseases
GWAS
Protein-Protein Interactions		117 interactors: ABTB1 ACTB ACVR1 AFF1 AP2A1 ARHGAP9 ARID1B ARNT ASB2 ASH2L BAZ1A BTG2 C10orf2 CAMSAP1 CEP135 CHPF CLPB CPXM2 CSH1 CSH2 CTR9 CXXC5 CYP11A1 DIAPH3 DKK1 DNAJA3 DNAJC7 DST DSTN E4F1 EIF3C EIF3E EIF3F ERVV-1 EVC2 EXPH5 FLI1 FN1 FTL GRN HEY1 HEYL HUWE1 KDM1A KDM6A KIAA0226 KMT2D LEMD3 LMO4 LNPEP LRP5 MAN1A2 MAN1C1 MAN2B1 MBD1 MCM3AP METAP1 MGAT1 MTMR10 MTMR11 NAGK OTUB1 PABPC4 PAPPA PELP1 PHKA2 PIR PKP2 PLEC PNPLA2 PPARD PPP2R5E PRMT6 PSAP PSMD8 QARS RANBP9 RFX1 RMND5A RNF123 RRBP1 SECISBP2 SF3B1 SIL1 SMAD2 SMAD3 SMAD4 SMG1 SNRNP70 SPTBN1 STAG1 SVEP1 TBCD TERF1 TINAGL1 TMEM57 TOB1 TRIM29 TRIP12 TTC37 UBA6 UBE3A UBQLN1 UBQLN4 UNC45A VCPIP1 VPS8 XAB2 YWHAQ ZEB2 ZNF484 ZNF557 ZNF587 ZNF587B ZNF592 ZNF83 ZSCAN4	8 interactors: HIST1H3A HIST2H3C HIST3H3 NKX2-5 SMAD9 SRF TBX5 TLE1
Entrez ID		4093	7403
HPRD ID		04484	02131
Ensembl ID		ENSG00000120693	ENSG00000147050
Uniprot IDs		O15198	F5H5V6 F5H6S1 F8W8R6 O15550 Q59HG3
PDB IDs			3AVR 3AVS
Enriched GO Terms of Interacting Partners?		Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Gene Expression Cellular Metabolic Process Transcription, DNA-templated Biosynthetic Process RNA Metabolic Process RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Cellular Process Cellular Protein Metabolic Process Protein Metabolic Process Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Gastrulation Anterior/posterior Pattern Specification Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Developmental Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Multicellular Organismal Development Atrioventricular Valve Morphogenesis Endoderm Development Nitrogen Compound Metabolic Process Formation Of Primary Germ Layer Cell Differentiation Atrioventricular Valve Development Regulation Of Transcription From RNA Polymerase II Promoter Anatomical Structure Development Transcription From RNA Polymerase II Promoter Organ Development Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Metabolic Process Embryo Development Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process SMAD Protein Complex Assembly Posttranscriptional Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Pattern Specification Process	Bundle Of His Development Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cardioblast Differentiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cardiac Muscle Cell Differentiation DNA Methylation On Cytosine Cardiac Ventricle Formation Cardiac Chamber Formation Cardiac Conduction System Development Nitrogen Compound Metabolic Process Cardiocyte Differentiation Gene Expression Positive Regulation Of Transcription Via Serum Response Element Binding Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Chromatin Silencing At RDNA Coronary Vasculature Development Cardiac Chamber Development Heart Trabecula Formation Positive Regulation Of DNA-templated Transcription, Initiation Atrial Septum Morphogenesis Atrial Septum Development Regulation Of DNA-templated Transcription, Initiation Cardiac Myofibril Assembly Cardiac Muscle Tissue Development Heart Trabecula Morphogenesis Regulation Of Transcription, DNA-templated Heart Morphogenesis Regulation Of Nucleic Acid-templated Transcription Striated Muscle Cell Differentiation Regulation Of RNA Biosynthetic Process Cardiac Atrium Morphogenesis Tube Development Positive Regulation Of Gene Expression Regulation Of RNA Metabolic Process Chromatin Silencing Regulation Of Developmental Growth Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of Cell Differentiation Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Trabecula Morphogenesis Striated Muscle Tissue Development Regulation Of Transcription From RNA Polymerase II Promoter Muscle Cell Differentiation Sarcomere Organization Positive Regulation Of Stem Cell Differentiation Ventricular Cardiac Muscle Tissue Development
Tagcloud ?			aacr bladder brca2 carriers clin clinicopathologic discovering drivers ercc2 exome fancd2 multimodality mutational noncarriers palb2 perioperative pt2 ptn res resected rfs somatic staging suboptimal tsc1 unc5c undiscovered usage warranted
Tagcloud (Difference) ?			aacr bladder brca2 carriers clin clinicopathologic discovering drivers ercc2 exome fancd2 multimodality mutational noncarriers palb2 perioperative pt2 ptn res resected rfs somatic staging suboptimal tsc1 unc5c undiscovered usage warranted
Tagcloud (Intersection) ?