SMAD9 and MAN2B1

Number of citations of the paper that reports this interaction (PubMedID 15231748)
54

Data Source:
HPRD (two hybrid)

		SMAD9	MAN2B1
Description		SMAD family member 9	mannosidase alpha class 2B member 1
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol SMAD Protein Complex Heteromeric SMAD Protein Complex	Extracellular Region Extracellular Space Nucleoplasm Lysosome Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Metal Ion Binding I-SMAD Binding	Catalytic Activity Alpha-mannosidase Activity Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Carbohydrate Binding Metal Ion Binding
	Biological Process	Osteoblast Differentiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Intracellular Iron Ion Homeostasis Transforming Growth Factor Beta Receptor Signaling Pathway Anatomical Structure Morphogenesis Cell Differentiation BMP Signaling Pathway Developmental Process Positive Regulation Of Transcription By RNA Polymerase II Stem Cell Differentiation SMAD Protein Signal Transduction Cellular Response To Growth Factor Stimulus Cellular Response To BMP Stimulus Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway	Carbohydrate Metabolic Process Mannose Metabolic Process Protein Deglycosylation Learning Or Memory Oligosaccharide Catabolic Process Protein Modification Process
Pathways		Signaling by BMP	Neutrophil degranulation Lysosomal oligosaccharide catabolism
Drugs
Diseases			alpha-Mannosidosis
GWAS		Coronary artery disease ( 29212778) Heel bone mineral density ( 28869591 30598549) Perioperative myocardial infarction in coronary artery bypass surgery ( 25948407) Spontaneous preterm birth (preterm birth) ( 25599974) Total body bone mineral density ( 29304378)	Pulmonary emphysema ( 24383474)
Interacting Genes		117 interacting genes: ABTB1 ACTB ACVR1 AFF1 AP2A1 ARHGAP9 ARID1B ARNT ASB2 ASH2L BAZ1A BTG2 CAMSAP1 CEP135 CHPF CLPB CPXM2 CSH1 CSH2 CTR9 CXXC5 CYP11A1 DIAPH3 DKK1 DNAJA3 DNAJC7 DST DSTN E4F1 EIF3C EIF3E EIF3F ERVV-1 EVC2 EXPH5 FLI1 FN1 FTL GRN HEY1 HEYL HUWE1 KDM1A KDM6A KMT2D LEMD3 LMO4 LNPEP LRP5 MACO1 MAN1A2 MAN1C1 MAN2B1 MBD1 MCM3AP METAP1 MGAT1 MTMR10 MTMR11 NAGK OTUB1 PABPC4 PAPPA PELP1 PHKA2 PIR PKP2 PLEC PNPLA2 PPARD PPP2R5E PRMT6 PSAP PSMD8 QARS1 RANBP9 RFX1 RMND5A RNF123 RRBP1 RUBCN SECISBP2 SF3B1 SIL1 SKIC3 SMAD2 SMAD3 SMAD4 SMG1 SNRNP70 SPTBN1 STAG1 SVEP1 TBCD TERF1 TINAGL1 TOB1 TRIM29 TRIP12 TWNK UBA6 UBE3A UBQLN1 UBQLN4 UNC45A VCPIP1 VPS8 XAB2 YWHAQ ZEB2 ZNF484 ZNF557 ZNF587 ZNF587B ZNF592 ZNF83 ZSCAN4	2 interacting genes: NKX3-1 SMAD9
Entrez ID		4093	4125
HPRD ID		04484	02007
Ensembl ID		ENSG00000120693	ENSG00000104774
Uniprot IDs		O15198	A8K6A7 O00754
PDB IDs		6FZT
Enriched GO Terms of Interacting Partners?		Macromolecule Metabolic Process Ameboidal-type Cell Migration Nucleus Regulation Of Primary Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Catabolic Process Regulation Of SMAD Protein Signal Transduction Regulation Of Gene Expression Macromolecule Biosynthetic Process SMAD Protein Complex Protein Metabolic Process Regulation Of RNA Metabolic Process Gastrulation Anterior/posterior Pattern Specification Heteromeric SMAD Protein Complex Nucleoplasm Negative Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process R-SMAD Binding Histone Methyltransferase Complex Proteolysis Activin Receptor Signaling Pathway RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Metal Ion Binding Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Metabolic Process MLL3/4 Complex Endoderm Development Catabolic Process Protein Catabolic Process Regionalization Formation Of Cytoplasmic Translation Initiation Complex Eukaryotic Translation Initiation Factor 3 Complex Activin Responsive Factor Complex Paraxial Mesoderm Morphogenesis Negative Regulation Of Autophagosome Maturation Golgi Apparatus Mannose Trimming Positive Regulation Of Macromolecule Metabolic Process Chromatin Remodeling Regulation Of Organelle Organization Ventricular Septum Morphogenesis	Positive Regulation Of Androgen Secretion MADS Box Domain Binding Dorsal Aorta Development DNA-binding Transcription Factor Activity Heteromeric SMAD Protein Complex SMAD Protein Complex Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Salivary Gland Development Branching Involved In Prostate Gland Morphogenesis Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Epithelial Cell Proliferation Involved In Prostate Gland Development I-SMAD Binding Prostate Gland Development Urogenital System Development Pharyngeal System Development SMAD Protein Signal Transduction Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Prostate Gland Epithelium Morphogenesis Androgen Receptor Signaling Pathway RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Cellular Response To BMP Stimulus DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Chromatin Aorta Development Metanephros Development Nuclear Estrogen Receptor Binding Transcription Regulator Inhibitor Activity Response To Testosterone Positive Regulation Of Transcription By RNA Polymerase II Somitogenesis Artery Development Site Of DNA Damage Cellular Response To Interleukin-1 Segmentation Nuclear Receptor Activity Anatomical Structure Morphogenesis Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Cellular Response To Xenobiotic Stimulus Intracellular Iron Ion Homeostasis Negative Regulation Of Reproductive Process BMP Signaling Pathway Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Response To Interleukin-1 Cellular Response To Steroid Hormone Stimulus Positive Regulation Of Lipid Transport Steroid Hormone Receptor Signaling Pathway
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