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SMAD9 and PSMD8
Number of citations of the paper that reports this interaction (PMID
15231748
)
65
Data Source:
HPRD
(two hybrid)
SMAD9
PSMD8
Gene Name
SMAD family member 9
proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Intracellular
Nucleus
Nucleoplasm
Transcription Factor Complex
Cytoplasm
Cytosol
Proteasome Complex
Nucleus
Nucleoplasm
Cytosol
Proteasome Regulatory Particle
Proteasome Accessory Complex
Extracellular Vesicular Exosome
Molecular Function
DNA Binding
Sequence-specific DNA Binding Transcription Factor Activity
Protein Binding
Transforming Growth Factor Beta Receptor, Pathway-specific Cytoplasmic Mediator Activity
Metal Ion Binding
Biological Process
Ureteric Bud Development
Response To Hypoxia
Mullerian Duct Regression
Transcription, DNA-templated
Protein Phosphorylation
Transforming Growth Factor Beta Receptor Signaling Pathway
BMP Signaling Pathway
Midbrain Development
Hindbrain Development
Intracellular Signal Transduction
Positive Regulation Of Cell Differentiation
Positive Regulation Of Transcription, DNA-templated
Cartilage Development
Bone Development
Cellular Response To Organic Cyclic Compound
G1/S Transition Of Mitotic Cell Cycle
Protein Polyubiquitination
Mitotic Cell Cycle
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Regulation Of Cellular Amino Acid Metabolic Process
Apoptotic Process
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Gene Expression
Viral Process
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cellular Nitrogen Compound Metabolic Process
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Small Molecule Metabolic Process
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways
Signaling by BMP
Hedgehog 'off' state
misspliced GSK3beta mutants stabilize beta-catenin
Hh ligand biogenesis disease
T41 mutants of beta-catenin aren't phosphorylated
Downstream signaling events of B Cell Receptor (BCR)
Degradation of beta-catenin by the destruction complex
Stabilization of p53
S33 mutants of beta-catenin aren't phosphorylated
AXIN mutants destabilize the destruction complex, activating WNT signaling
Removal of licensing factors from origins
Switching of origins to a post-replicative state
Mitotic G1-G1/S phases
Regulation of mRNA stability by proteins that bind AU-rich elements
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
DNA Replication Pre-Initiation
S45 mutants of beta-catenin aren't phosphorylated
APC/C:Cdc20 mediated degradation of mitotic proteins
Regulation of APC/C activators between G1/S and early anaphase
SCF(Skp2)-mediated degradation of p27/p21
deletions in the AMER1 gene destabilize the destruction complex
Autodegradation of the E3 ubiquitin ligase COP1
AMER1 mutants destabilize the destruction complex
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
PCP/CE pathway
Adaptive Immune System
CDK-mediated phosphorylation and removal of Cdc6
Hedgehog ligand biogenesis
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
HIV Infection
Ubiquitin-dependent degradation of Cyclin D
APC truncation mutants have impaired AXIN binding
Assembly of the pre-replicative complex
Autodegradation of Cdh1 by Cdh1:APC/C
p53-Dependent G1 DNA Damage Response
S37 mutants of beta-catenin aren't phosphorylated
XAV939 inhibits tankyrase, stabilizing AXIN
p53-Independent DNA Damage Response
p53-Independent G1/S DNA damage checkpoint
G1/S DNA Damage Checkpoints
Vpu mediated degradation of CD4
Synthesis of DNA
M/G1 Transition
Ubiquitin-dependent degradation of Cyclin D1
TCF dependent signaling in response to WNT
SCF-beta-TrCP mediated degradation of Emi1
degradation of AXIN
Signaling by Hedgehog
Regulation of mitotic cell cycle
Degradation of GLI1 by the proteasome
degradation of DVL
Cell Cycle Checkpoints
Signaling by WNT in cancer
GLI3 is processed to GLI3R by the proteasome
Regulation of Apoptosis
Degradation of GLI2 by the proteasome
Signaling by the B Cell Receptor (BCR)
Vif-mediated degradation of APOBEC3G
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
p53-Dependent G1/S DNA damage checkpoint
truncated APC mutants destabilize the destruction complex
TCF7L2 mutants don't bind CTBP
Signaling by Wnt
Cyclin E associated events during G1/S transition
APC/C:Cdc20 mediated degradation of Securin
AUF1 (hnRNP D0) destabilizes mRNA
CDK-mediated phosphorylation and removal of Cdc6
RNF mutants show enhanced WNT signaling and proliferation
G1/S Transition
truncations of AMER1 destabilize the destruction complex
Processing-defective Hh variants abrogate ligand secretion
Host Interactions of HIV factors
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
Regulation of activated PAK-2p34 by proteasome mediated degradation
AXIN missense mutants destabilize the destruction complex
S Phase
APC/C-mediated degradation of cell cycle proteins
Cyclin A:Cdk2-associated events at S phase entry
SCF(Skp2)-mediated degradation of p27/p21
Mitotic Metaphase and Anaphase
Regulation of ornithine decarboxylase (ODC)
Antigen processing: Ubiquitination & Proteasome degradation
Orc1 removal from chromatin
Mitotic Anaphase
M Phase
APC truncation mutants are not K63 polyubiquitinated
Metabolism of amino acids and derivatives
Hedgehog 'on' state
Programmed Cell Death
Class I MHC mediated antigen processing & presentation
Regulation of DNA replication
Cell Cycle, Mitotic
beta-catenin independent WNT signaling
Orc1 removal from chromatin
Activation of NF-kappaB in B cells
Asymmetric localization of PCP proteins
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
Cross-presentation of soluble exogenous antigens (endosomes)
Antigen processing-Cross presentation
CDT1 association with the CDC6:ORC:origin complex
ER-Phagosome pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions
117 interactors:
ABTB1
ACTB
ACVR1
AFF1
AP2A1
ARHGAP9
ARID1B
ARNT
ASB2
ASH2L
BAZ1A
BTG2
C10orf2
CAMSAP1
CEP135
CHPF
CLPB
CPXM2
CSH1
CSH2
CTR9
CXXC5
CYP11A1
DIAPH3
DKK1
DNAJA3
DNAJC7
DST
DSTN
E4F1
EIF3C
EIF3E
EIF3F
ERVV-1
EVC2
EXPH5
FLI1
FN1
FTL
GRN
HEY1
HEYL
HUWE1
KDM1A
KDM6A
KIAA0226
KMT2D
LEMD3
LMO4
LNPEP
LRP5
MAN1A2
MAN1C1
MAN2B1
MBD1
MCM3AP
METAP1
MGAT1
MTMR10
MTMR11
NAGK
OTUB1
PABPC4
PAPPA
PELP1
PHKA2
PIR
PKP2
PLEC
PNPLA2
PPARD
PPP2R5E
PRMT6
PSAP
PSMD8
QARS
RANBP9
RFX1
RMND5A
RNF123
RRBP1
SECISBP2
SF3B1
SIL1
SMAD2
SMAD3
SMAD4
SMG1
SNRNP70
SPTBN1
STAG1
SVEP1
TBCD
TERF1
TINAGL1
TMEM57
TOB1
TRIM29
TRIP12
TTC37
UBA6
UBE3A
UBQLN1
UBQLN4
UNC45A
VCPIP1
VPS8
XAB2
YWHAQ
ZEB2
ZNF484
ZNF557
ZNF587
ZNF587B
ZNF592
ZNF83
ZSCAN4
3 interactors:
SMAD2
SMAD9
UCHL5
Entrez ID
4093
5714
HPRD ID
04484
10171
Ensembl ID
ENSG00000120693
ENSG00000099341
Uniprot IDs
O15198
P48556
PDB IDs
Enriched GO Terms of Interacting Partners
?
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Gene Expression
Cellular Metabolic Process
Transcription, DNA-templated
Biosynthetic Process
RNA Metabolic Process
RNA Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Regulation Of Metabolic Process
Cellular Process
Cellular Protein Metabolic Process
Protein Metabolic Process
Regulation Of Gene Expression
Nucleobase-containing Compound Metabolic Process
Gastrulation
Anterior/posterior Pattern Specification
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Positive Regulation Of Gene Expression
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Protein Metabolic Process
Positive Regulation Of Transcription, DNA-templated
Negative Regulation Of Gene Expression
Developmental Process
Cellular Nitrogen Compound Metabolic Process
Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Multicellular Organismal Development
Atrioventricular Valve Morphogenesis
Endoderm Development
Nitrogen Compound Metabolic Process
Formation Of Primary Germ Layer
Cell Differentiation
Atrioventricular Valve Development
Regulation Of Transcription From RNA Polymerase II Promoter
Anatomical Structure Development
Transcription From RNA Polymerase II Promoter
Organ Development
Negative Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Metabolic Process
Embryo Development
Negative Regulation Of RNA Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
SMAD Protein Complex Assembly
Posttranscriptional Regulation Of Gene Expression
Negative Regulation Of Transcription, DNA-templated
Pattern Specification Process
Transforming Growth Factor Beta Receptor Signaling Pathway
Cellular Response To Transforming Growth Factor Beta Stimulus
Response To Transforming Growth Factor Beta
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Cellular Response To Growth Factor Stimulus
Response To Growth Factor
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Midbrain Development
Enzyme Linked Receptor Protein Signaling Pathway
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Negative Regulation Of Cellular Response To Growth Factor Stimulus
Ureteric Bud Development
Mesonephric Tubule Development
Mesonephric Epithelium Development
Mesonephros Development
Kidney Epithelium Development
Regulation Of Cellular Response To Growth Factor Stimulus
Positive Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry
Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry
Zygotic Specification Of Dorsal/ventral Axis
Kidney Development
Cellular Response To Organic Substance
Renal System Development
Positive Regulation Of Mesoderm Development
Primary MiRNA Processing
Urogenital System Development
Regulation Of Nodal Signaling Pathway
Common-partner SMAD Protein Phosphorylation
Cellular Response To Organic Cyclic Compound
Positive Regulation Of Activin Receptor Signaling Pathway
Mullerian Duct Regression
Transcription, DNA-templated
RNA Biosynthetic Process
Anatomical Structure Morphogenesis
Response To Organic Substance
SMAD Protein Complex Assembly
Skeletal System Development
Paraxial Mesoderm Morphogenesis
Nodal Signaling Pathway
Organ Development
Anatomical Structure Regression
Cell Surface Receptor Signaling Pathway
RNA Metabolic Process
Cellular Protein Modification Process
Tube Development
Production Of MiRNAs Involved In Gene Silencing By MiRNA
Embryonic Foregut Morphogenesis
Forebrain Morphogenesis
Foregut Morphogenesis
Tagcloud
?
bewo
bioinformatics
cd44
cdc123
chfr
choose
choriocarcinoma
consist
curable
dissimilar
has2
htr8
ic
jeg3
mimicking
muc3a
park7
placenta
placental
possesses
s100
s100p
svneo
taf7
trimester
trophoblast
trophoblastic
tumorigenesis
uterus
Tagcloud (Difference)
?
bewo
bioinformatics
cd44
cdc123
chfr
choose
choriocarcinoma
consist
curable
dissimilar
has2
htr8
ic
jeg3
mimicking
muc3a
park7
placenta
placental
possesses
s100
s100p
svneo
taf7
trimester
trophoblast
trophoblastic
tumorigenesis
uterus
Tagcloud (Intersection)
?