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SMAD9 and PSMD8
Number of citations of the paper that reports this interaction (PubMedID
15231748
)
54
Data Source:
HPRD
(two hybrid)
SMAD9
PSMD8
Description
SMAD family member 9
proteasome 26S subunit, non-ATPase 8
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Cytosol
SMAD Protein Complex
Heteromeric SMAD Protein Complex
Proteasome Complex
Nucleus
Nucleoplasm
Cytosol
Proteasome Regulatory Particle
Proteasome Regulatory Particle, Lid Subcomplex
Proteasome Accessory Complex
Protein-containing Complex
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Metal Ion Binding
I-SMAD Binding
Protein Binding
Biological Process
Osteoblast Differentiation
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Intracellular Iron Ion Homeostasis
Transforming Growth Factor Beta Receptor Signaling Pathway
Anatomical Structure Morphogenesis
Cell Differentiation
BMP Signaling Pathway
Developmental Process
Positive Regulation Of Transcription By RNA Polymerase II
Stem Cell Differentiation
SMAD Protein Signal Transduction
Cellular Response To Growth Factor Stimulus
Cellular Response To BMP Stimulus
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Proteolysis
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways
Signaling by BMP
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
Assembly of the pre-replicative complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G2/M Checkpoints
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
KEAP1-NFE2L2 pathway
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
Degradation of CDH1
Somitogenesis
Antigen processing: Ubiquitination & Proteasome degradation
Proteasome assembly
Proteasome assembly
GSK3B-mediated proteasomal degradation of PD-L1(CD274)
SPOP-mediated proteasomal degradation of PD-L1(CD274)
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
Degradation of CRY and PER proteins
Degradation of CRY and PER proteins
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Drugs
Diseases
GWAS
Coronary artery disease (
29212778
)
Heel bone mineral density (
28869591
30598549
)
Perioperative myocardial infarction in coronary artery bypass surgery (
25948407
)
Spontaneous preterm birth (preterm birth) (
25599974
)
Total body bone mineral density (
29304378
)
HDL cholesterol levels (
32203549
)
Interacting Genes
117 interacting genes:
ABTB1
ACTB
ACVR1
AFF1
AP2A1
ARHGAP9
ARID1B
ARNT
ASB2
ASH2L
BAZ1A
BTG2
CAMSAP1
CEP135
CHPF
CLPB
CPXM2
CSH1
CSH2
CTR9
CXXC5
CYP11A1
DIAPH3
DKK1
DNAJA3
DNAJC7
DST
DSTN
E4F1
EIF3C
EIF3E
EIF3F
ERVV-1
EVC2
EXPH5
FLI1
FN1
FTL
GRN
HEY1
HEYL
HUWE1
KDM1A
KDM6A
KMT2D
LEMD3
LMO4
LNPEP
LRP5
MACO1
MAN1A2
MAN1C1
MAN2B1
MBD1
MCM3AP
METAP1
MGAT1
MTMR10
MTMR11
NAGK
OTUB1
PABPC4
PAPPA
PELP1
PHKA2
PIR
PKP2
PLEC
PNPLA2
PPARD
PPP2R5E
PRMT6
PSAP
PSMD8
QARS1
RANBP9
RFX1
RMND5A
RNF123
RRBP1
RUBCN
SECISBP2
SF3B1
SIL1
SKIC3
SMAD2
SMAD3
SMAD4
SMG1
SNRNP70
SPTBN1
STAG1
SVEP1
TBCD
TERF1
TINAGL1
TOB1
TRIM29
TRIP12
TWNK
UBA6
UBE3A
UBQLN1
UBQLN4
UNC45A
VCPIP1
VPS8
XAB2
YWHAQ
ZEB2
ZNF484
ZNF557
ZNF587
ZNF587B
ZNF592
ZNF83
ZSCAN4
10 interacting genes:
GLP1R
GSK3A
GSK3B
MTNR1B
PRDX6
SHC3
SMAD2
SMAD9
UBC
UCHL5
Entrez ID
4093
5714
HPRD ID
04484
10171
Ensembl ID
ENSG00000120693
ENSG00000099341
Uniprot IDs
O15198
P48556
V9HW09
PDB IDs
6FZT
5GJQ
5GJR
5L4K
5LN3
5M32
5T0C
5T0G
5T0H
5T0I
5T0J
5VFP
5VFQ
5VFR
5VFS
5VFT
5VFU
5VGZ
5VHF
5VHH
5VHI
5VHS
6MSB
6MSD
6MSG
6MSH
6MSJ
6MSK
6WJD
6WJN
7QXN
7QXP
7QXU
7QXW
7QXX
7QY7
7QYA
7QYB
7W37
7W38
7W39
7W3A
7W3B
7W3C
7W3F
7W3G
7W3H
7W3I
7W3J
7W3K
7W3M
8CVT
8JRI
8JRT
8JTI
8K0G
8USB
8USC
9E8G
9E8H
9E8I
9E8J
9E8K
9E8L
9E8N
9E8O
9E8Q
Enriched GO Terms of Interacting Partners
?
Macromolecule Metabolic Process
Ameboidal-type Cell Migration
Nucleus
Regulation Of Primary Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Regulation Of Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Macromolecule Catabolic Process
Regulation Of SMAD Protein Signal Transduction
Regulation Of Gene Expression
Macromolecule Biosynthetic Process
SMAD Protein Complex
Protein Metabolic Process
Regulation Of RNA Metabolic Process
Gastrulation
Anterior/posterior Pattern Specification
Heteromeric SMAD Protein Complex
Nucleoplasm
Negative Regulation Of Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
R-SMAD Binding
Histone Methyltransferase Complex
Proteolysis
Activin Receptor Signaling Pathway
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Metal Ion Binding
Positive Regulation Of Epithelial To Mesenchymal Transition
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of RNA Metabolic Process
MLL3/4 Complex
Endoderm Development
Catabolic Process
Protein Catabolic Process
Regionalization
Formation Of Cytoplasmic Translation Initiation Complex
Eukaryotic Translation Initiation Factor 3 Complex
Activin Responsive Factor Complex
Paraxial Mesoderm Morphogenesis
Negative Regulation Of Autophagosome Maturation
Golgi Apparatus Mannose Trimming
Positive Regulation Of Macromolecule Metabolic Process
Chromatin Remodeling
Regulation Of Organelle Organization
Ventricular Septum Morphogenesis
Negative Regulation Of Type B Pancreatic Cell Development
Negative Regulation Of Glycogen (starch) Synthase Activity
Regulation Of Glycogen (starch) Synthase Activity
Tau Protein Binding
Beta-arrestin-dependent Dopamine Receptor Signaling Pathway
Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules
Cellular Response To Interleukin-3
SMAD Protein Complex
Regulation Of Type B Pancreatic Cell Development
Heteromeric SMAD Protein Complex
Negative Regulation Of Glycogen Biosynthetic Process
Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Beta-catenin Destruction Complex
Protein Kinase A Catalytic Subunit Binding
I-SMAD Binding
Tau-protein Kinase Activity
Ubiquitin Protein Ligase Binding
Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
SMAD Protein Signal Transduction
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Viral Protein Processing
Positive Regulation Of Mitochondrial Membrane Permeability
Enzyme-linked Receptor Protein Signaling Pathway
Regulation Of Glycogen Biosynthetic Process
Positive Regulation Of Membrane Permeability
Negative Regulation Of Catalytic Activity
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Regulation Of Glycogen Metabolic Process
Negative Regulation Of Multicellular Organismal Process
Glucagon-like Peptide 1 Receptor Activity
Negative Regulation Of UDP-glucose Catabolic Process
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Microtubule Anchoring At Centrosome
Oxidized DNA Binding
Regulation Of Proteasomal Protein Catabolic Process
Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules
Positive Regulation Of RNA Metabolic Process
Glycogen Metabolic Process
Regulation Of Mitochondrial Membrane Permeability
Excitatory Postsynaptic Potential
Positive Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway
Superior Temporal Gyrus Development
Negative Regulation Of Mesenchymal Stem Cell Differentiation
Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Proteasomal Protein Catabolic Process
Homomeric SMAD Protein Complex
Susceptibility To T Cell Mediated Cytotoxicity
Positive Regulation Of Respiratory Burst Involved In Inflammatory Response
Negative Regulation Of Protein ADP-ribosylation
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