FN1 and KPNA2

Number of citations of the paper that reports this interaction (PMID 19738201)
51

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		FN1	KPNA2
Gene Name		fibronectin 1	karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Fibrinogen Complex Basal Lamina Extracellular Space Endoplasmic Reticulum-Golgi Intermediate Compartment Apical Plasma Membrane Extracellular Matrix Platelet Alpha Granule Lumen Extracellular Vesicular Exosome Blood Microparticle	Nucleoplasm Cytoplasm Cytosol Membrane
	Molecular Function	Protease Binding Integrin Binding Protein Binding Collagen Binding Heparin Binding Peptidase Activator Activity	Protein Binding Nuclear Localization Sequence Binding Protein Transporter Activity Histone Deacetylase Binding Poly(A) RNA Binding
	Biological Process	Angiogenesis Platelet Degranulation Acute-phase Response Cell-substrate Junction Assembly Cell Adhesion Calcium-independent Cell-matrix Adhesion Blood Coagulation Regulation Of Cell Shape Response To Wounding Positive Regulation Of Peptidase Activity Peptide Cross-linking Extracellular Matrix Disassembly Platelet Activation Extracellular Matrix Organization Integrin Activation Substrate Adhesion-dependent Cell Spreading Endodermal Cell Differentiation Positive Regulation Of Axon Extension Leukocyte Migration	Regulation Of DNA Recombination DNA Metabolic Process NLS-bearing Protein Import Into Nucleus Viral Process Cytokine-mediated Signaling Pathway
Pathways		Elastic fibre formation p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling GRB2:SOS provides linkage to MAPK signaling for Integrins Non-integrin membrane-ECM interactions Platelet degranulation Platelet Aggregation (Plug Formation) Degradation of the extracellular matrix Cell surface interactions at the vascular wall Molecules associated with elastic fibres Syndecan interactions ECM proteoglycans Fibronectin matrix formation Response to elevated platelet cytosolic Ca2+ Integrin cell surface interactions Platelet activation, signaling and aggregation	ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Antiviral mechanism by IFN-stimulated genes
Drugs		Ocriplasmin
Diseases
GWAS
Protein-Protein Interactions		96 interactors: ADAMTS4 AMBP APCS ATXN10 ATXN7 C1QA CD44 CDKN2A COL13A1 COL1A1 COL1A2 COL2A1 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 COL6A2 COL7A1 COMP CRP CTSD CXCL12 DCN DUSP10 EGFR F13A1 FAM86B3P FASLG FBLN1 FBLN2 FST FSTL3 GALNT6 GRB2 GSN HGF HRG HSPG2 IGFBP3 IGFBP5 ITGA3 ITGA4 ITGA5 ITGA8 ITGB1 ITGB3 ITGB6 ITGB7 KLK3 KPNA2 LACRT LGALS3BP LPA LRG1 LTBP1 MAG MATN2 MEP1A MEP1B MIA MMP9 MYOC NOV NR0B2 NT5E PELI2 PKD1 PLAT PLG PRELP PRPF40A RARA RBL1 REG3A RPS6KA5 SCGB1A1 SDC2 SKIL SMAD4 SMAD9 SPARC STAT5A TAB1 TAB2 TAC1 TGFBI TGM2 THBS1 TMPRSS6 TNC TNFRSF11B TSHR UBQLN1 VHL	104 interactors: ACTN1 ACTN4 ANKIB1 AP2B1 APOBEC1 APP ARL4A ARL5A BRCA1 BTBD2 CASP2 CCDC107 CDA CDK5RAP3 CHD3 CHEK2 CORO1B CREB3L3 CREBBP CSE1L CSNK1A1 CUL4B DCTN2 DDIT3 EP300 EPB41 FEZ2 FN1 FTH1 GART GMCL1 GRB2 H1F0 HAP1 HMG20A HNRNPC HOMER2 HOMEZ HSPA4 IFT20 IMMT INO80E ITK JUN KLC4 KPNB1 KRT18 KRT40 KRT8 LAMB2 LEF1 LZTS2 MAGED1 MAGEH1 MDFI MLH1 MORC3 MVP MYC NECAB2 NFKBIB NMNAT1 NR3C1 NUP153 NUP50 NUP62 NUTM1 PAX5 PLAG1 PNMA5 PRKD3 PTMA RAG1 RAN RANBP2 RBM48 RBPMS RECQL RELA RELB RGL2 RILP RNMT SART3 SERTAD3 SGK1 SLC2A2 SPRY1 SRPK1 TADA2A TAF3 TAF8 TANK TBPL2 TP53 TRAF1 TRIM54 TSC22D4 TXNIP UBR5 USHBP1 ZBTB7B ZC3H12A ZNF131
Entrez ID		2335	3838
HPRD ID		00626	02818
Ensembl ID		ENSG00000115414	ENSG00000182481
Uniprot IDs		P02751 Q6MZF4 Q6MZM7 Q6N084 Q9UQS6	P52292 Q7Z726
PDB IDs		1E88 1E8B 1FBR 1FNA 1FNF 1FNH 1J8K 1O9A 1OWW 1Q38 1QGB 1QO6 1TTF 1TTG 2CG6 2CG7 2CK2 2CKU 2EC3 2FN2 2FNB 2GEE 2H41 2H45 2HA1 2OCF 2RKY 2RKZ 2RL0 3CAL 3EJH 3GXE 3M7P 3MQL 3R8Q 3T1W 3ZRZ 4GH7 4JE4 4JEG	1EFX 1QGK 1QGR 3FEX 3FEY 4E4V
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Developmental Process Multicellular Organismal Development Anatomical Structure Morphogenesis System Development Anatomical Structure Development Collagen Catabolic Process Response To Stimulus Response To External Stimulus Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Locomotion Multicellular Organismal Metabolic Process Cell Differentiation Wound Healing Tissue Development Response To Wounding Axon Guidance Response To Growth Factor Response To Organic Substance Organ Development Response To Stress Cellular Response To Stimulus Cell Morphogenesis Involved In Differentiation Movement Of Cell Or Subcellular Component Neurogenesis Generation Of Neurons Chemotaxis Regulation Of Cell Adhesion Cell Adhesion Axon Development Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Axonogenesis Cell Projection Organization Cell Morphogenesis Cardiovascular System Development Nervous System Development Neuron Projection Development Skeletal System Development Cell Morphogenesis Involved In Neuron Differentiation Anatomical Structure Formation Involved In Morphogenesis Neuron Development Regulation Of Locomotion Organ Morphogenesis Cell Communication Neuron Projection Morphogenesis	Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Regulation Of Cellular Process RNA Biosynthetic Process Gene Expression Response To Stimulus Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Cell Death Death Apoptotic Process Transcription, DNA-templated Regulation Of RNA Metabolic Process Programmed Cell Death Viral Process Organelle Organization Regulation Of Nucleic Acid-templated Transcription Signal Transduction Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Developmental Process Regulation Of Transcription, DNA-templated Signaling Positive Regulation Of Transcription, DNA-templated Protein Localization To Nucleus Macromolecule Biosynthetic Process Cellular Localization Cell Cycle Negative Regulation Of Biosynthetic Process Cell Communication Negative Regulation Of Nucleic Acid-templated Transcription Cellular Process Negative Regulation Of RNA Biosynthetic Process Cell Cycle Process Response To Stress Positive Regulation Of Gene Expression Nucleocytoplasmic Transport Negative Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Response To Abiotic Stimulus Negative Regulation Of Transcription, DNA-templated Nuclear Transport Positive Regulation Of Macromolecule Biosynthetic Process Multicellular Organismal Development
Tagcloud ?		2q33 2q34 artificial bcg brazilian exon il8 il8r il8ra il8rb ity leishmaniasis leprosy linkage lod lsh nramp pedigrees proline pseudogene q35 q37 segregating sh3 synteny tnp1 typed vil1 visceral	aggressive aggressiveness assembled attempt carcinomas curable diagnostics disregarding eic emgd endometrial entities figo immunoreactivity interplay introducing malignancy mediator mfe microarrays nucleocytoplasmic precancerous regimens surgically tmas trp53 tumour untreatable uterus
Tagcloud (Difference) ?		2q33 2q34 artificial bcg brazilian exon il8 il8r il8ra il8rb ity leishmaniasis leprosy linkage lod lsh nramp pedigrees proline pseudogene q35 q37 segregating sh3 synteny tnp1 typed vil1 visceral	aggressive aggressiveness assembled attempt carcinomas curable diagnostics disregarding eic emgd endometrial entities figo immunoreactivity interplay introducing malignancy mediator mfe microarrays nucleocytoplasmic precancerous regimens surgically tmas trp53 tumour untreatable uterus
Tagcloud (Intersection) ?