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FN1 and CTSD
Number of citations of the paper that reports this interaction (PubMedID
3988746
)
0
Data Source:
HPRD
(in vivo)
FN1
CTSD
Description
fibronectin 1
cathepsin D
Image
GO Annotations
Cellular Component
Extracellular Region
Fibrinogen Complex
Basement Membrane
Extracellular Space
Endoplasmic Reticulum Lumen
Endoplasmic Reticulum-Golgi Intermediate Compartment
Plasma Membrane
Apical Plasma Membrane
Extracellular Matrix
Platelet Alpha Granule Lumen
Extracellular Exosome
Blood Microparticle
Extracellular Region
Extracellular Space
Cytoplasm
Lysosome
Lysosomal Membrane
Cytosol
Endosome Membrane
Extracellular Matrix
Endosome Lumen
Specific Granule Lumen
Melanosome
Lysosomal Lumen
Membrane Raft
Extracellular Exosome
Tertiary Granule Lumen
Ficolin-1-rich Granule Lumen
Molecular Function
Protease Binding
Signaling Receptor Binding
Integrin Binding
Extracellular Matrix Structural Constituent
Protein Binding
Collagen Binding
Heparin Binding
Peptidase Activator Activity
Identical Protein Binding
Proteoglycan Binding
Receptor Ligand Activity
Endopeptidase Activity
Aspartic-type Endopeptidase Activity
Cysteine-type Endopeptidase Activity
Protein Binding
Peptidase Activity
Hydrolase Activity
Aspartic-type Peptidase Activity
Biological Process
Angiogenesis
Regulation Of Protein Phosphorylation
Acute-phase Response
Cell-substrate Junction Assembly
Cell Adhesion
Cell-matrix Adhesion
Calcium-independent Cell-matrix Adhesion
Integrin-mediated Signaling Pathway
Nervous System Development
Heart Development
Positive Regulation Of Cell Population Proliferation
Regulation Of Cell Shape
Response To Wounding
Positive Regulation Of Gene Expression
Response To Muscle Activity
Integrin Activation
Substrate Adhesion-dependent Cell Spreading
Endodermal Cell Differentiation
Wound Healing
Endothelial Cell Migration
Positive Regulation Of Axon Extension
Positive Regulation Of Fibroblast Proliferation
Biological Process Involved In Interaction With Symbiont
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of ERK1 And ERK2 Cascade
Negative Regulation Of Transforming Growth Factor Beta Production
Blood Coagulation, Fibrin Clot Formation
Negative Regulation Of Monocyte Activation
Neural Crest Cell Migration Involved In Autonomic Nervous System Development
Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate
Autophagosome Assembly
Proteolysis
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Insulin Receptor Recycling
Lipoprotein Catabolic Process
Positive Regulation Of Apoptotic Process
Regulation Of Establishment Of Protein Localization
Execution Phase Of Apoptosis
Insulin Catabolic Process
Pathways
Platelet degranulation
Degradation of the extracellular matrix
Degradation of the extracellular matrix
Fibronectin matrix formation
Cell surface interactions at the vascular wall
Molecules associated with elastic fibres
Integrin cell surface interactions
Syndecan interactions
Non-integrin membrane-ECM interactions
ECM proteoglycans
Integrin signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
MAP2K and MAPK activation
Interleukin-4 and Interleukin-13 signaling
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF1 fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
MET activates PTK2 signaling
Post-translational protein phosphorylation
GPER1 signaling
Attachment of bacteria to epithelial cells
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
ALK mutants bind TKIs
Signaling by ALK fusions and activated point mutants
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Developmental Lineage of Pancreatic Ductal Cells
Collagen degradation
Metabolism of Angiotensinogen to Angiotensins
MHC class II antigen presentation
Neutrophil degranulation
Insulin receptor recycling
Estrogen-dependent gene expression
Drugs
Zinc
Lanoteplase
Ocriplasmin
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
S-Methylcysteine
1h-Benoximidazole-2-Carboxylic Acid
2-Morpholinoethylamine
5-Amino-6-cyclohexyl-4-hydroxy-2-isobutyl-hexanoic acid
CYCLOHEXYLMETHYL-2,3-DIHYDROXY-5-METHYL-HEXYLAMIDE
Diseases
Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
Neuronal ceroid lipofuscinosis, including: Infantile Neuronal Ceroid Lipofuscinosis (INCL)/ Santavuori-Haltia Disease (CLN1); Late-Infantile Neuronal Ceroid Lipofuscinosis (LINCL)/ Jansky-Bielschowsky Disease (CLN2); Juvenile Neuronal Ceroid Lipofuscinosis (JNCL)/Batten Disease/ Spielmeyer-Vogt Disease (CLN3); Adult Neuronal Ceroid Lipofuscinosis (ANCL)/ Kufs Disease (CLN4); LINCL variant (CLN5, CLN6, CLN7, CLN8); Batten Disease variant (CLN9); Congenital NCL (CLN10)
GWAS
Apolipoprotein B levels (
32203549
)
Cholesterol, total (
26780889
)
Coronary artery disease (
33020668
32469254
29212778
28714974
)
Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) (
28714975
)
Diastolic blood pressure (
30578418
)
Iron status biomarkers (ferritin levels) (
33536631
)
LDL cholesterol (
24097068
)
LDL cholesterol levels (
28334899
32203549
)
Lymphocyte count (
32888494
)
Monocyte count (
32888494
)
Myocardial infarction (
33532862
)
Negative urgency (
30718321
)
Pulse pressure (
30578418
28135244
27841878
)
Systolic blood pressure (
30578418
27841878
)
Total cholesterol levels (
28334899
)
White blood cell count (
32888494
)
Aspartate aminotransferase levels (
33547301
)
Blood protein levels (
30072576
)
Blood protein levels in cardiovascular risk (
28369058
)
Logical memory (delayed recall) in mild cognitive impairment (
29274321
)
Interacting Genes
111 interacting genes:
ADAMTS4
AMBP
ANOS1
APCS
ATXN10
ATXN7
C1QA
CCN3
CD44
CDKN2A
COL13A1
COL1A1
COL1A2
COL2A1
COL4A1
COL4A2
COL4A3
COL4A4
COL4A5
COL4A6
COL6A2
COL7A1
COL9A1
COMP
CRP
CTSD
CXCL12
DCN
DSCR9
DUSP10
EGFR
F13A1
FAM86B3P
FASLG
FBLN1
FBLN2
FST
FSTL3
GALNT6
GRB2
GSN
HGF
HOXA1
HRG
HSP90AA1
HSPG2
IGFBP3
IGFBP5
ITGA2B
ITGA3
ITGA4
ITGA5
ITGA8
ITGB1
ITGB3
ITGB6
ITGB7
KLK3
KPNA2
LACRT
LGALS3BP
LPA
LRG1
LTBP1
MAG
MATN2
MEP1A
MEP1B
MIA
MMP9
MTDH
MTNR1A
MYOC
NR0B2
NT5E
PELI2
PKD1
PLAT
PLG
PRELP
PRPF40A
RARA
RBL1
REG3A
RPS6KA5
RSPH1
SCGB1A1
SDC2
SGCA
SH3GLB1
SKIL
SMAD4
SMAD9
SPARC
STAT5A
TAB1
TAB2
TAC1
TGFBI
TGM2
THBS1
TIMD4
TLR4
TMPRSS6
TNC
TNFRSF11B
TSHR
TTN
UBQLN1
VEGFA
VHL
25 interacting genes:
APP
BGLAP
CCL21
CD4
CST3
CSTB
CTSB
FN1
HSPB2
IGF2R
IGFBP3
IGFBP4
INS
MAPK1
MAPT
NEAT1
NLGN3
OGT
PSAP
SERPINA4
SHBG
SLC2A4
SNCA
SPRED2
TG
Entrez ID
2335
1509
HPRD ID
00626
00291
Ensembl ID
ENSG00000115414
ENSG00000117984
Uniprot IDs
B7ZLE5
P02751
Q9UQS6
P07339
V9HWI3
PDB IDs
1E88
1E8B
1FBR
1FNA
1FNF
1FNH
1J8K
1O9A
1OWW
1Q38
1QGB
1QO6
1TTF
1TTG
2CG6
2CG7
2CK2
2CKU
2EC3
2FN2
2FNB
2GEE
2H41
2H45
2HA1
2MNU
2N1K
2OCF
2RKY
2RKZ
2RL0
3CAL
3EJH
3GXE
3M7P
3MQL
3R8Q
3T1W
3ZRZ
4GH7
4JE4
4JEG
4LXO
4MMX
4MMY
4MMZ
4PZ5
5DC0
5DC4
5DC9
5DFT
5J6Z
5J7C
5M0A
5N47
5N48
6HNF
6MFA
6MSV
6NAJ
6XAX
6XAY
7NWL
8PEQ
1LYA
1LYB
1LYW
4OBZ
4OC6
4OD9
Enriched GO Terms of Interacting Partners
?
Extracellular Matrix
Extracellular Region
Extracellular Space
Extracellular Matrix Structural Constituent
Extracellular Matrix Structural Constituent Conferring Tensile Strength
Fibronectin Binding
Extracellular Matrix Organization
Extracellular Structure Organization
Basement Membrane
Collagen Trimer
Enzyme-linked Receptor Protein Signaling Pathway
Cell Surface Receptor Signaling Pathway
Integrin Binding
Cell Adhesion
Endoplasmic Reticulum Lumen
Cell Surface
Developmental Process
Negative Regulation Of Multicellular Organismal Process
Collagen Type IV Trimer
Integrin Complex
Signal Transduction
Negative Regulation Of Developmental Process
Regulation Of Multicellular Organismal Process
Response To Growth Factor
Cell-matrix Adhesion
Regulation Of Cell Adhesion
Extracellular Matrix Binding
Anatomical Structure Morphogenesis
Collagen-activated Tyrosine Kinase Receptor Signaling Pathway
Regulation Of Vasculature Development
Cell-cell Adhesion
Positive Regulation Of Cell Migration
Regulation Of Cell Migration
Positive Regulation Of Cell Motility
Regulation Of Developmental Process
Regulation Of Multicellular Organismal Development
Positive Regulation Of Locomotion
Regulation Of Apoptotic Process
Collagen-activated Signaling Pathway
Regulation Of Angiogenesis
Regulation Of Cell Motility
Collagen Binding
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Cell-substrate Adhesion
Cell Adhesion Mediated By Integrin
Regulation Of Cellular Response To Growth Factor Stimulus
Regulation Of Programmed Cell Death
Regulation Of Cell Population Proliferation
Regulation Of Locomotion
Integrin-mediated Signaling Pathway
Extracellular Space
Extracellular Region
Endoplasmic Reticulum Lumen
Regulation Of Small Molecule Metabolic Process
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Synaptic Transmission
Insulin-like Growth Factor II Binding
Regulation Of MAPK Cascade
Cognition
Regulation Of Protein Metabolic Process
Protease Binding
Insulin-like Growth Factor Binding
Regulation Of Phosphorus Metabolic Process
Learning Or Memory
Type B Pancreatic Cell Proliferation
Modulation Of Chemical Synaptic Transmission
Positive Regulation Of Signal Transduction
Regulation Of Lipid Metabolic Process
Regulation Of Developmental Process
Regulation Of Synaptic Plasticity
Amyloid Fibril Formation
Response To Cytokine
Regulation Of Cellular Component Organization
Microglial Cell Activation
Response To Peptide
Regulation Of Multicellular Organismal Process
Regulation Of Glucose Metabolic Process
Regulation Of Cell Communication
Leukocyte Activation Involved In Inflammatory Response
Regulation Of Signaling
Identical Protein Binding
Cysteine-type Endopeptidase Inhibitor Activity
Negative Regulation Of Protein Metabolic Process
Regulation Of Signal Transduction
Cell-cell Signaling
Positive Regulation Of Intracellular Signal Transduction
Peptidase Inhibitor Activity
Main Axon
Cellular Response To Oxygen-containing Compound
Signaling
Negative Regulation Of Protein Catabolic Process
Ficolin-1-rich Granule Lumen
Cell Communication
Regulation Of Generation Of Precursor Metabolites And Energy
Positive Regulation Of MAPK Cascade
Regulation Of Reactive Oxygen Species Metabolic Process
Regulation Of Intracellular Signal Transduction
Regulation Of ERK1 And ERK2 Cascade
Negative Regulation Of Proteolysis
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Tagcloud (Difference)
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Tagcloud (Intersection)
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