FN1 and C1QA

Number of citations of the paper that reports this interaction (PubMedID 6981115)
29

Data Source:
HPRD (in vitro)

		FN1	C1QA
Description		fibronectin 1	complement C1q A chain
Image
GO Annotations	Cellular Component	Extracellular Region Fibrinogen Complex Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Plasma Membrane Apical Plasma Membrane Extracellular Matrix Platelet Alpha Granule Lumen Extracellular Exosome Blood Microparticle	Extracellular Region Collagen Trimer Complement Component C1 Complex Cell Surface Extracellular Matrix Synapse Complement Component C1q Complex Postsynapse Extrinsic Component Of Presynaptic Membrane Extrinsic Component Of Postsynaptic Membrane Glutamatergic Synapse Symbiont Cell Surface
	Molecular Function	Protease Binding Signaling Receptor Binding Integrin Binding Extracellular Matrix Structural Constituent Protein Binding Collagen Binding Heparin Binding Peptidase Activator Activity Identical Protein Binding Proteoglycan Binding Receptor Ligand Activity	Amyloid-beta Binding Phosphatidylserine Binding IgM Binding Protein Binding IgG Binding
	Biological Process	Angiogenesis Regulation Of Protein Phosphorylation Acute-phase Response Cell-substrate Junction Assembly Cell Adhesion Cell-matrix Adhesion Calcium-independent Cell-matrix Adhesion Integrin-mediated Signaling Pathway Nervous System Development Heart Development Positive Regulation Of Cell Population Proliferation Regulation Of Cell Shape Response To Wounding Positive Regulation Of Gene Expression Response To Muscle Activity Integrin Activation Substrate Adhesion-dependent Cell Spreading Endodermal Cell Differentiation Wound Healing Endothelial Cell Migration Positive Regulation Of Axon Extension Positive Regulation Of Fibroblast Proliferation Biological Process Involved In Interaction With Symbiont Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Transforming Growth Factor Beta Production Blood Coagulation, Fibrin Clot Formation Negative Regulation Of Monocyte Activation Neural Crest Cell Migration Involved In Autonomic Nervous System Development Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate	Microglial Cell Activation Immune System Process Complement Activation Complement Activation, Classical Pathway Cell-cell Signaling Neuron Remodeling Innate Immune Response Astrocyte Activation Synapse Organization Synapse Pruning Complement-mediated Synapse Pruning Vertebrate Eye-specific Patterning
Pathways		Platelet degranulation Degradation of the extracellular matrix Degradation of the extracellular matrix Fibronectin matrix formation Cell surface interactions at the vascular wall Molecules associated with elastic fibres Integrin cell surface interactions Syndecan interactions Non-integrin membrane-ECM interactions ECM proteoglycans Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) MAP2K and MAPK activation Interleukin-4 and Interleukin-13 signaling Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF MET activates PTK2 signaling Post-translational protein phosphorylation GPER1 signaling Attachment of bacteria to epithelial cells Signaling downstream of RAS mutants Signaling by RAF1 mutants ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Developmental Lineage of Pancreatic Ductal Cells	Initial triggering of complement Classical antibody-mediated complement activation Regulation of Complement cascade
Drugs		Zinc Lanoteplase Ocriplasmin Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Cetuximab Etanercept Palivizumab Daclizumab Bevacizumab
Diseases			Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency
GWAS		Apolipoprotein B levels ( 32203549) Cholesterol, total ( 26780889) Coronary artery disease ( 33020668 32469254 29212778 28714974) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Diastolic blood pressure ( 30578418) Iron status biomarkers (ferritin levels) ( 33536631) LDL cholesterol ( 24097068) LDL cholesterol levels ( 28334899 32203549) Lymphocyte count ( 32888494) Monocyte count ( 32888494) Myocardial infarction ( 33532862) Negative urgency ( 30718321) Pulse pressure ( 30578418 28135244 27841878) Systolic blood pressure ( 30578418 27841878) Total cholesterol levels ( 28334899) White blood cell count ( 32888494)	Inflammatory biomarkers (multivariate analysis) ( 33110245)
Interacting Genes		111 interacting genes: ADAMTS4 AMBP ANOS1 APCS ATXN10 ATXN7 C1QA CCN3 CD44 CDKN2A COL13A1 COL1A1 COL1A2 COL2A1 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 COL6A2 COL7A1 COL9A1 COMP CRP CTSD CXCL12 DCN DSCR9 DUSP10 EGFR F13A1 FAM86B3P FASLG FBLN1 FBLN2 FST FSTL3 GALNT6 GRB2 GSN HGF HOXA1 HRG HSP90AA1 HSPG2 IGFBP3 IGFBP5 ITGA2B ITGA3 ITGA4 ITGA5 ITGA8 ITGB1 ITGB3 ITGB6 ITGB7 KLK3 KPNA2 LACRT LGALS3BP LPA LRG1 LTBP1 MAG MATN2 MEP1A MEP1B MIA MMP9 MTDH MTNR1A MYOC NR0B2 NT5E PELI2 PKD1 PLAT PLG PRELP PRPF40A RARA RBL1 REG3A RPS6KA5 RSPH1 SCGB1A1 SDC2 SGCA SH3GLB1 SKIL SMAD4 SMAD9 SPARC STAT5A TAB1 TAB2 TAC1 TGFBI TGM2 THBS1 TIMD4 TLR4 TMPRSS6 TNC TNFRSF11B TSHR TTN UBQLN1 VEGFA VHL	31 interacting genes: APCS BAG6 C1QB C1QBP C1QC C1R C1S CD93 COL2A1 CR1 CRP CSPG4 DCN FN1 GNPNAT1 HIPK3 HMGB1 HRG HSPB2 NLGN3 PIAS2 PPP1CA PPP1CC PTX3 SGTA SGTB SLC25A47 TXN UBQLN1 UBQLN2 USP40
Entrez ID		2335	712
HPRD ID		00626	00393
Ensembl ID		ENSG00000115414	ENSG00000173372
Uniprot IDs		B7ZLE5 P02751 Q9UQS6	P02745
PDB IDs		1E88 1E8B 1FBR 1FNA 1FNF 1FNH 1J8K 1O9A 1OWW 1Q38 1QGB 1QO6 1TTF 1TTG 2CG6 2CG7 2CK2 2CKU 2EC3 2FN2 2FNB 2GEE 2H41 2H45 2HA1 2MNU 2N1K 2OCF 2RKY 2RKZ 2RL0 3CAL 3EJH 3GXE 3M7P 3MQL 3R8Q 3T1W 3ZRZ 4GH7 4JE4 4JEG 4LXO 4MMX 4MMY 4MMZ 4PZ5 5DC0 5DC4 5DC9 5DFT 5J6Z 5J7C 5M0A 5N47 5N48 6HNF 6MFA 6MSV 6NAJ 6XAX 6XAY 7NWL 8PEQ	1PK6 2JG8 2JG9 2WNU 2WNV 5HKJ 5HZF 6FCZ 6Z6V 9C9L 9C9U
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Extracellular Region Extracellular Space Extracellular Matrix Structural Constituent Extracellular Matrix Structural Constituent Conferring Tensile Strength Fibronectin Binding Extracellular Matrix Organization Extracellular Structure Organization Basement Membrane Collagen Trimer Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Integrin Binding Cell Adhesion Endoplasmic Reticulum Lumen Cell Surface Developmental Process Negative Regulation Of Multicellular Organismal Process Collagen Type IV Trimer Integrin Complex Signal Transduction Negative Regulation Of Developmental Process Regulation Of Multicellular Organismal Process Response To Growth Factor Cell-matrix Adhesion Regulation Of Cell Adhesion Extracellular Matrix Binding Anatomical Structure Morphogenesis Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Regulation Of Vasculature Development Cell-cell Adhesion Positive Regulation Of Cell Migration Regulation Of Cell Migration Positive Regulation Of Cell Motility Regulation Of Developmental Process Regulation Of Multicellular Organismal Development Positive Regulation Of Locomotion Regulation Of Apoptotic Process Collagen-activated Signaling Pathway Regulation Of Angiogenesis Regulation Of Cell Motility Collagen Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Cell-substrate Adhesion Cell Adhesion Mediated By Integrin Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Programmed Cell Death Regulation Of Cell Population Proliferation Regulation Of Locomotion Integrin-mediated Signaling Pathway	Complement Component C1q Complex Binding Complement Activation, Classical Pathway Complement Component C1 Complex Complement Activation Blood Microparticle Cell Surface Opsonization Immune Effector Process Positive Regulation Of ERAD Pathway Symbiont Cell Surface Defense Response To Symbiont Defense Response To Other Organism Regulation Of ERAD Pathway Innate Immune Response Regulation Of Protein Metabolic Process Extracellular Region Response To Stress Humoral Immune Response Virion Binding Activation Of Immune Response Extracellular Matrix Positive Regulation Of Response To Endoplasmic Reticulum Stress Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Response To External Biotic Stimulus Regulation Of Immune System Process Immune System Process Positive Regulation Of Immune Response Defense Response Response To Other Organism Negative Regulation By Host Of Viral Glycoprotein Metabolic Process TRC Complex Regulation Of Immune Response Immune Response Extracellular Space Identical Protein Binding Negative Regulation Of Endothelial Cell Migration Complement Component C1q Complex Positive Regulation Of Immune System Process Protein Targeting To ER Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway Regulation Of Multicellular Organismal Development Establishment Of Protein Localization To Endoplasmic Reticulum IgM Binding Positive Regulation Of Proteolysis Negative Regulation Of Immune System Process Polyubiquitin Modification-dependent Protein Binding Acute-phase Response Positive Regulation Of Proteasomal Protein Catabolic Process Postsynapse
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