SMAD9 and PPARD

Number of citations of the paper that reports this interaction (PMID 15231748)
65

Data Source:
HPRD (two hybrid)

		SMAD9	PPARD
Gene Name		SMAD family member 9	peroxisome proliferator-activated receptor delta
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol	Nucleus Nucleoplasm
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transforming Growth Factor Beta Receptor, Pathway-specific Cytoplasmic Mediator Activity Metal Ion Binding	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Transcription Coactivator Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Drug Binding Zinc Ion Binding Lipid Binding Sequence-specific DNA Binding NF-kappaB Binding Linoleic Acid Binding
	Biological Process	Ureteric Bud Development Response To Hypoxia Mullerian Duct Regression Transcription, DNA-templated Protein Phosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway BMP Signaling Pathway Midbrain Development Hindbrain Development Intracellular Signal Transduction Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription, DNA-templated Cartilage Development Bone Development Cellular Response To Organic Cyclic Compound	Negative Regulation Of Transcription From RNA Polymerase II Promoter Glucose Metabolic Process Proteoglycan Metabolic Process Generation Of Precursor Metabolites And Energy Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Lipid Metabolic Process Fatty Acid Beta-oxidation Vitamin A Metabolic Process Heart Development Embryo Implantation Cholesterol Metabolic Process Cell Proliferation Positive Regulation Of Cell Proliferation Axon Ensheathment Phospholipid Biosynthetic Process Fatty Acid Catabolic Process MRNA Transcription Response To Glucose Gene Expression Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Response To Activity Negative Regulation Of Smooth Muscle Cell Migration Glucose Transport Fatty Acid Transport Cell Differentiation Negative Regulation Of Cell Growth Intracellular Receptor Signaling Pathway Cell-substrate Adhesion Positive Regulation Of Insulin Secretion Negative Regulation Of Collagen Biosynthetic Process Response To Vitamin A Wound Healing Negative Regulation Of Apoptotic Process Steroid Hormone Mediated Signaling Pathway Keratinocyte Proliferation Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Epidermis Development Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Vasodilation Decidualization Negative Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Inflammatory Response Keratinocyte Migration Adipose Tissue Development Cellular Response To Hypoxia Apoptotic Signaling Pathway
Pathways		Signaling by BMP	Regulation of pyruvate dehydrogenase (PDH) complex Pyruvate metabolism Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Generic Transcription Pathway Signaling by Retinoic Acid Import of palmitoyl-CoA into the mitochondrial matrix Pyruvate metabolism and Citric Acid (TCA) cycle Nuclear Receptor transcription pathway The citric acid (TCA) cycle and respiratory electron transport
Drugs			Icosapent Treprostinil Sulindac Bezafibrate Heptyl-Beta-D-Glucopyranoside (11E)-OCTADEC-11-ENOIC ACID (2S)-2-{3-[({[2-fluoro-4-(trifluoromethyl)phenyl]carbonyl}amino)methyl]-4-methoxybenzyl}butanoic acid 2-({[3-(3,4-dihydroisoquinolin-2(1H)-ylsulfonyl)phenyl]carbonyl}amino)benzoic acid 3-{5-methoxy-1-[(4-methoxyphenyl)sulfonyl]-1H-indol-3-yl}propanoic acid {4-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]phenoxy}acetic acid
Diseases
GWAS			Cataracts in type 2 diabetes ( 23137000) Height ( 21998595) Pulmonary function (interaction) ( 23284291) Response to antipsychotic treatment ( 20195266)
Protein-Protein Interactions		117 interactors: ABTB1 ACTB ACVR1 AFF1 AP2A1 ARHGAP9 ARID1B ARNT ASB2 ASH2L BAZ1A BTG2 C10orf2 CAMSAP1 CEP135 CHPF CLPB CPXM2 CSH1 CSH2 CTR9 CXXC5 CYP11A1 DIAPH3 DKK1 DNAJA3 DNAJC7 DST DSTN E4F1 EIF3C EIF3E EIF3F ERVV-1 EVC2 EXPH5 FLI1 FN1 FTL GRN HEY1 HEYL HUWE1 KDM1A KDM6A KIAA0226 KMT2D LEMD3 LMO4 LNPEP LRP5 MAN1A2 MAN1C1 MAN2B1 MBD1 MCM3AP METAP1 MGAT1 MTMR10 MTMR11 NAGK OTUB1 PABPC4 PAPPA PELP1 PHKA2 PIR PKP2 PLEC PNPLA2 PPARD PPP2R5E PRMT6 PSAP PSMD8 QARS RANBP9 RFX1 RMND5A RNF123 RRBP1 SECISBP2 SF3B1 SIL1 SMAD2 SMAD3 SMAD4 SMG1 SNRNP70 SPTBN1 STAG1 SVEP1 TBCD TERF1 TINAGL1 TMEM57 TOB1 TRIM29 TRIP12 TTC37 UBA6 UBE3A UBQLN1 UBQLN4 UNC45A VCPIP1 VPS8 XAB2 YWHAQ ZEB2 ZNF484 ZNF557 ZNF587 ZNF587B ZNF592 ZNF83 ZSCAN4	39 interactors: BCL6 CEP350 DUT EIF3I EP300 GADD45B GADD45G GLUL HDAC1 HDAC2 HDAC3 HDAC4 HDAC7 HSP90AA1 ITGB5 KDM1A KRTAP10-3 KRTAP10-7 NCOA1 NCOA2 NCOA3 NCOR1 NCOR2 NR0B2 NRIP1 PEBP1 PPARGC1A PRDX6 PRMT3 PROX1 RANBP9 RXRA RXRB RXRG SHMT2 SMAD9 SPEN SRC TNP1
Entrez ID		4093	5467
HPRD ID		04484	02679
Ensembl ID		ENSG00000120693	ENSG00000112033
Uniprot IDs		O15198	F1D8S7 Q03181
PDB IDs			1GWX 1Y0S 2AWH 2B50 2BAW 2ENV 2GWX 2J14 2Q5G 2XYJ 2XYW 2XYX 2ZNP 2ZNQ 3D5F 3DY6 3ET2 3GWX 3GZ9 3OZ0 3PEQ 3SP9 3TKM
Enriched GO Terms of Interacting Partners?		Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Gene Expression Cellular Metabolic Process Transcription, DNA-templated Biosynthetic Process RNA Metabolic Process RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Cellular Process Cellular Protein Metabolic Process Protein Metabolic Process Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Gastrulation Anterior/posterior Pattern Specification Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Developmental Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Multicellular Organismal Development Atrioventricular Valve Morphogenesis Endoderm Development Nitrogen Compound Metabolic Process Formation Of Primary Germ Layer Cell Differentiation Atrioventricular Valve Development Regulation Of Transcription From RNA Polymerase II Promoter Anatomical Structure Development Transcription From RNA Polymerase II Promoter Organ Development Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Metabolic Process Embryo Development Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process SMAD Protein Complex Assembly Posttranscriptional Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Pattern Specification Process	Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Transcription, DNA-templated Negative Regulation Of Gene Expression Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Rhythmic Process Chromatin Organization Positive Regulation Of Macromolecule Biosynthetic Process Chromatin Modification Positive Regulation Of Metabolic Process Circadian Rhythm Response To Organic Substance Histone Modification Cellular Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Intracellular Receptor Signaling Pathway Circadian Regulation Of Gene Expression Gene Expression Regulation Of Transcription, DNA-templated Histone H4 Deacetylation Multicellular Organismal Development Cellular Response To Organic Substance Organelle Organization Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Biosynthetic Process RNA Metabolic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Chromosome Organization Developmental Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Cell Differentiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Metabolic Process Histone H3 Deacetylation
Tagcloud ?			almendro birc5 casein catenin cd44 deregulate distinguished dvl1 ffpe fzd7 gonen ly294002 martins mimicking mmp7 modulators notch1 pam50 park pten readout subpopulation sulfide sulindac tnbc wp xav939 zymograph
Tagcloud (Difference) ?			almendro birc5 casein catenin cd44 deregulate distinguished dvl1 ffpe fzd7 gonen ly294002 martins mimicking mmp7 modulators notch1 pam50 park pten readout subpopulation sulfide sulindac tnbc wp xav939 zymograph
Tagcloud (Intersection) ?