FN1 and HSPG2

Number of citations of the paper that reports this interaction (PMID 19738201)
51

Data Source:
BioGRID (pull down, affinity chromatography technology)

		FN1	HSPG2
Gene Name		fibronectin 1	heparan sulfate proteoglycan 2
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Fibrinogen Complex Basal Lamina Extracellular Space Endoplasmic Reticulum-Golgi Intermediate Compartment Apical Plasma Membrane Extracellular Matrix Platelet Alpha Granule Lumen Extracellular Vesicular Exosome Blood Microparticle	Extracellular Region Basal Lamina Extracellular Space Golgi Lumen Plasma Membrane Focal Adhesion Extracellular Matrix Lysosomal Lumen Extracellular Vesicular Exosome
	Molecular Function	Protease Binding Integrin Binding Protein Binding Collagen Binding Heparin Binding Peptidase Activator Activity	Protein Binding Protein C-terminus Binding Metal Ion Binding
	Biological Process	Angiogenesis Platelet Degranulation Acute-phase Response Cell-substrate Junction Assembly Cell Adhesion Calcium-independent Cell-matrix Adhesion Blood Coagulation Regulation Of Cell Shape Response To Wounding Positive Regulation Of Peptidase Activity Peptide Cross-linking Extracellular Matrix Disassembly Platelet Activation Extracellular Matrix Organization Integrin Activation Substrate Adhesion-dependent Cell Spreading Endodermal Cell Differentiation Positive Regulation Of Axon Extension Leukocyte Migration	Retinoid Metabolic Process Angiogenesis Endochondral Ossification Chondrocyte Differentiation Carbohydrate Metabolic Process Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Brain Development Phototransduction, Visible Light Protein Localization Pathogenesis Extracellular Matrix Disassembly Extracellular Matrix Organization Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Lipoprotein Metabolic Process Small Molecule Metabolic Process Embryonic Skeletal System Morphogenesis Cardiac Muscle Tissue Development Cartilage Development Involved In Endochondral Bone Morphogenesis
Pathways		Elastic fibre formation p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling GRB2:SOS provides linkage to MAPK signaling for Integrins Non-integrin membrane-ECM interactions Platelet degranulation Platelet Aggregation (Plug Formation) Degradation of the extracellular matrix Cell surface interactions at the vascular wall Molecules associated with elastic fibres Syndecan interactions ECM proteoglycans Fibronectin matrix formation Response to elevated platelet cytosolic Ca2+ Integrin cell surface interactions Platelet activation, signaling and aggregation	Lipoprotein metabolism Metabolism of lipids and lipoproteins MPS I - Hurler syndrome MPS IX - Natowicz syndrome Glycosaminoglycan metabolism Degradation of the extracellular matrix Amyloids Defective CHST14 causes EDS, musculocontractural type Laminin interactions Myoclonic epilepsy of Lafora MPS IIID - Sanfilippo syndrome D Glycogen storage diseases Defective CHST6 causes MCDC1 Retinoid metabolism and transport Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 Diseases associated with visual transduction MPS IV - Morquio syndrome A Integrin cell surface interactions Metabolism of carbohydrates HS-GAG biosynthesis MPS VI - Maroteaux-Lamy syndrome MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Heparan sulfate/heparin (HS-GAG) metabolism Defective B4GALT7 causes EDS, progeroid type Chylomicron-mediated lipid transport Chondroitin sulfate/dermatan sulfate metabolism Defective SLC26A2 causes chondrodysplasias Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A A tetrasaccharide linker sequence is required for GAG synthesis MPS IIIC - Sanfilippo syndrome C MPS II - Hunter syndrome Defective CHST3 causes SEDCJD Defective B3GAT3 causes JDSSDHD Lipid digestion, mobilization, and transport Non-integrin membrane-ECM interactions Defective EXT1 causes exostoses 1, TRPS2 and CHDS Visual phototransduction Defective CHSY1 causes TPBS MPS IV - Morquio syndrome B MPS VII - Sly syndrome HS-GAG degradation
Drugs		Ocriplasmin	Palifermin
Diseases
GWAS
Protein-Protein Interactions		96 interactors: ADAMTS4 AMBP APCS ATXN10 ATXN7 C1QA CD44 CDKN2A COL13A1 COL1A1 COL1A2 COL2A1 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 COL6A2 COL7A1 COMP CRP CTSD CXCL12 DCN DUSP10 EGFR F13A1 FAM86B3P FASLG FBLN1 FBLN2 FST FSTL3 GALNT6 GRB2 GSN HGF HRG HSPG2 IGFBP3 IGFBP5 ITGA3 ITGA4 ITGA5 ITGA8 ITGB1 ITGB3 ITGB6 ITGB7 KLK3 KPNA2 LACRT LGALS3BP LPA LRG1 LTBP1 MAG MATN2 MEP1A MEP1B MIA MMP9 MYOC NOV NR0B2 NT5E PELI2 PKD1 PLAT PLG PRELP PRPF40A RARA RBL1 REG3A RPS6KA5 SCGB1A1 SDC2 SKIL SMAD4 SMAD9 SPARC STAT5A TAB1 TAB2 TAC1 TGFBI TGM2 THBS1 TMPRSS6 TNC TNFRSF11B TSHR UBQLN1 VHL	29 interactors: APP ATF7IP ATN1 BMP1 CACNA1A COL13A1 CTGF ECM1 FBLN1 FBLN2 FBN1 FGF2 FGF7 FGFBP1 FN1 GFI1B GRN ITGA2 ITGB1 LAMA1 NID1 NID2 PDGFA PDGFB PRELP PRPF40A SPARC TTR VWA1
Entrez ID		2335	3339
HPRD ID		00626	00804
Ensembl ID		ENSG00000115414	ENSG00000142798
Uniprot IDs		P02751 Q6MZF4 Q6MZM7 Q6N084 Q9UQS6	P98160
PDB IDs		1E88 1E8B 1FBR 1FNA 1FNF 1FNH 1J8K 1O9A 1OWW 1Q38 1QGB 1QO6 1TTF 1TTG 2CG6 2CG7 2CK2 2CKU 2EC3 2FN2 2FNB 2GEE 2H41 2H45 2HA1 2OCF 2RKY 2RKZ 2RL0 3CAL 3EJH 3GXE 3M7P 3MQL 3R8Q 3T1W 3ZRZ 4GH7 4JE4 4JEG	3SH4 3SH5
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Developmental Process Multicellular Organismal Development Anatomical Structure Morphogenesis System Development Anatomical Structure Development Collagen Catabolic Process Response To Stimulus Response To External Stimulus Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Locomotion Multicellular Organismal Metabolic Process Cell Differentiation Wound Healing Tissue Development Response To Wounding Axon Guidance Response To Growth Factor Response To Organic Substance Organ Development Response To Stress Cellular Response To Stimulus Cell Morphogenesis Involved In Differentiation Movement Of Cell Or Subcellular Component Neurogenesis Generation Of Neurons Chemotaxis Regulation Of Cell Adhesion Cell Adhesion Axon Development Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Axonogenesis Cell Projection Organization Cell Morphogenesis Cardiovascular System Development Nervous System Development Neuron Projection Development Skeletal System Development Cell Morphogenesis Involved In Neuron Differentiation Anatomical Structure Formation Involved In Morphogenesis Neuron Development Regulation Of Locomotion Organ Morphogenesis Cell Communication Neuron Projection Morphogenesis	Extracellular Matrix Organization Extracellular Structure Organization Multicellular Organismal Development Cell-matrix Adhesion System Development Developmental Process Anatomical Structure Development Cell-substrate Adhesion Response To Wounding Organ Development Locomotion Regulation Of Cell Migration Positive Regulation Of Cell Proliferation Platelet Degranulation Blood Vessel Morphogenesis Regulation Of Cell Motility Cardiovascular System Development Positive Regulation Of Epithelial Cell Migration Regulation Of Locomotion Regulation Of Cellular Component Movement Positive Regulation Of Cell Migration Extracellular Matrix Disassembly Positive Regulation Of Cell Motility Blood Vessel Development Secretion By Cell Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Vasculature Development Anatomical Structure Morphogenesis Response To Growth Factor Wound Healing Positive Regulation Of Cellular Protein Metabolic Process Chemotaxis Regulation Of Cell Proliferation Blood Coagulation Secretion Hemostasis Regulation Of Epithelial Cell Migration Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Metabolic Process Regulation Of Epithelial Cell Proliferation Regulation Of Cellular Protein Metabolic Process Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Phosphatidylinositol Biosynthetic Process Organ Morphogenesis Angiogenesis Tissue Development Exocytosis Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor
Tagcloud ?		2q33 2q34 artificial bcg brazilian exon il8 il8r il8ra il8rb ity leishmaniasis leprosy linkage lod lsh nramp pedigrees proline pseudogene q35 q37 segregating sh3 synteny tnp1 typed vil1 visceral	akathisia bradykinesia drd3 drd4 dyskinesia dystonia fluctuating grin2a grin2b htr2c naturalistic nominal orofacial parkinsonism preferably rater rs10772715 rs11644461 rs11866328 rs1345423 rs1650420 rs2192970 rs324035 rs4911871 rs7192557 tardive td tremor truncal
Tagcloud (Difference) ?		2q33 2q34 artificial bcg brazilian exon il8 il8r il8ra il8rb ity leishmaniasis leprosy linkage lod lsh nramp pedigrees proline pseudogene q35 q37 segregating sh3 synteny tnp1 typed vil1 visceral	akathisia bradykinesia drd3 drd4 dyskinesia dystonia fluctuating grin2a grin2b htr2c naturalistic nominal orofacial parkinsonism preferably rater rs10772715 rs11644461 rs11866328 rs1345423 rs1650420 rs2192970 rs324035 rs4911871 rs7192557 tardive td tremor truncal
Tagcloud (Intersection) ?