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FN1 and CCN3
Number of citations of the paper that reports this interaction (PubMedID
12902636
)
0
Data Source:
HPRD
(in vitro)
FN1
CCN3
Description
fibronectin 1
cellular communication network factor 3
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Fibrinogen Complex
Basement Membrane
Extracellular Space
Endoplasmic Reticulum Lumen
Endoplasmic Reticulum-Golgi Intermediate Compartment
Plasma Membrane
Apical Plasma Membrane
Extracellular Matrix
Platelet Alpha Granule Lumen
Extracellular Exosome
Blood Microparticle
Extracellular Region
Extracellular Space
Cytoplasm
Cytosol
Gap Junction
Extracellular Matrix
Anchoring Junction
Molecular Function
Protease Binding
Signaling Receptor Binding
Integrin Binding
Extracellular Matrix Structural Constituent
Protein Binding
Collagen Binding
Heparin Binding
Peptidase Activator Activity
Identical Protein Binding
Proteoglycan Binding
Receptor Ligand Activity
Signaling Receptor Binding
Notch Binding
Integrin Binding
Hormone Activity
Protein Binding
Growth Factor Activity
Heparin Binding
Biological Process
Angiogenesis
Regulation Of Protein Phosphorylation
Acute-phase Response
Cell-substrate Junction Assembly
Cell Adhesion
Cell-matrix Adhesion
Calcium-independent Cell-matrix Adhesion
Integrin-mediated Signaling Pathway
Nervous System Development
Heart Development
Positive Regulation Of Cell Population Proliferation
Regulation Of Cell Shape
Response To Wounding
Positive Regulation Of Gene Expression
Response To Muscle Activity
Integrin Activation
Substrate Adhesion-dependent Cell Spreading
Endodermal Cell Differentiation
Wound Healing
Endothelial Cell Migration
Positive Regulation Of Axon Extension
Positive Regulation Of Fibroblast Proliferation
Biological Process Involved In Interaction With Symbiont
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of ERK1 And ERK2 Cascade
Negative Regulation Of Transforming Growth Factor Beta Production
Blood Coagulation, Fibrin Clot Formation
Negative Regulation Of Monocyte Activation
Neural Crest Cell Migration Involved In Autonomic Nervous System Development
Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate
Angiogenesis
Chondrocyte Differentiation
Cell Adhesion
Signal Transduction
Fibroblast Migration
Negative Regulation Of Myotube Differentiation
Smooth Muscle Cell Migration
Negative Regulation Of Cell Growth
Cell Adhesion Mediated By Integrin
Endothelial Cell Chemotaxis
Type B Pancreatic Cell Proliferation
Positive Regulation Of Cell Differentiation
Positive Regulation Of Notch Signaling Pathway
Positive Regulation Of Ossification
Negative Regulation Of Insulin Secretion
Smooth Muscle Cell Proliferation
Negative Regulation Of Inflammatory Response
Regulation Of Developmental Process
Cell Chemotaxis
Negative Regulation Of SMAD Protein Signal Transduction
Hematopoietic Stem Cell Homeostasis
Endothelial Cell-cell Adhesion
Negative Regulation Of Monocyte Chemotaxis
Negative Regulation Of Non-canonical NF-kappaB Signal Transduction
Negative Regulation Of Chondrocyte Proliferation
Negative Regulation Of Sensory Perception Of Pain
Bone Regeneration
Pathways
Platelet degranulation
Degradation of the extracellular matrix
Degradation of the extracellular matrix
Fibronectin matrix formation
Cell surface interactions at the vascular wall
Molecules associated with elastic fibres
Integrin cell surface interactions
Syndecan interactions
Non-integrin membrane-ECM interactions
ECM proteoglycans
Integrin signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
MAP2K and MAPK activation
Interleukin-4 and Interleukin-13 signaling
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF1 fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
MET activates PTK2 signaling
Post-translational protein phosphorylation
GPER1 signaling
Attachment of bacteria to epithelial cells
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
ALK mutants bind TKIs
Signaling by ALK fusions and activated point mutants
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Developmental Lineage of Pancreatic Ductal Cells
Drugs
Zinc
Lanoteplase
Ocriplasmin
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Insulin human
Diseases
GWAS
Apolipoprotein B levels (
32203549
)
Cholesterol, total (
26780889
)
Coronary artery disease (
33020668
32469254
29212778
28714974
)
Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) (
28714975
)
Diastolic blood pressure (
30578418
)
Iron status biomarkers (ferritin levels) (
33536631
)
LDL cholesterol (
24097068
)
LDL cholesterol levels (
28334899
32203549
)
Lymphocyte count (
32888494
)
Monocyte count (
32888494
)
Myocardial infarction (
33532862
)
Negative urgency (
30718321
)
Pulse pressure (
30578418
28135244
27841878
)
Systolic blood pressure (
30578418
27841878
)
Total cholesterol levels (
28334899
)
White blood cell count (
32888494
)
Interacting Genes
111 interacting genes:
ADAMTS4
AMBP
ANOS1
APCS
ATXN10
ATXN7
C1QA
CCN3
CD44
CDKN2A
COL13A1
COL1A1
COL1A2
COL2A1
COL4A1
COL4A2
COL4A3
COL4A4
COL4A5
COL4A6
COL6A2
COL7A1
COL9A1
COMP
CRP
CTSD
CXCL12
DCN
DSCR9
DUSP10
EGFR
F13A1
FAM86B3P
FASLG
FBLN1
FBLN2
FST
FSTL3
GALNT6
GRB2
GSN
HGF
HOXA1
HRG
HSP90AA1
HSPG2
IGFBP3
IGFBP5
ITGA2B
ITGA3
ITGA4
ITGA5
ITGA8
ITGB1
ITGB3
ITGB6
ITGB7
KLK3
KPNA2
LACRT
LGALS3BP
LPA
LRG1
LTBP1
MAG
MATN2
MEP1A
MEP1B
MIA
MMP9
MTDH
MTNR1A
MYOC
NR0B2
NT5E
PELI2
PKD1
PLAT
PLG
PRELP
PRPF40A
RARA
RBL1
REG3A
RPS6KA5
RSPH1
SCGB1A1
SDC2
SGCA
SH3GLB1
SKIL
SMAD4
SMAD9
SPARC
STAT5A
TAB1
TAB2
TAC1
TGFBI
TGM2
THBS1
TIMD4
TLR4
TMPRSS6
TNC
TNFRSF11B
TSHR
TTN
UBQLN1
VEGFA
VHL
31 interacting genes:
ADSL
ANKRD11
APOL6
C11orf87
CCN2
CDKN1A
COL8A1
DLL1
FAM90A1
FBLN1
FN1
FRS3
FXR1
FXR2
GJA1
HOXA1
IGF1
IGF2
INS
ITGAV
KRTAP5-6
LCE1A
LCE3D
NID2
NOTCH1
POLR2L
POU4F2
RECK
S100A4
TNIP3
ZNF330
Entrez ID
2335
4856
HPRD ID
00626
01291
Ensembl ID
ENSG00000115414
ENSG00000136999
Uniprot IDs
B7ZLE5
P02751
Q9UQS6
P48745
PDB IDs
1E88
1E8B
1FBR
1FNA
1FNF
1FNH
1J8K
1O9A
1OWW
1Q38
1QGB
1QO6
1TTF
1TTG
2CG6
2CG7
2CK2
2CKU
2EC3
2FN2
2FNB
2GEE
2H41
2H45
2HA1
2MNU
2N1K
2OCF
2RKY
2RKZ
2RL0
3CAL
3EJH
3GXE
3M7P
3MQL
3R8Q
3T1W
3ZRZ
4GH7
4JE4
4JEG
4LXO
4MMX
4MMY
4MMZ
4PZ5
5DC0
5DC4
5DC9
5DFT
5J6Z
5J7C
5M0A
5N47
5N48
6HNF
6MFA
6MSV
6NAJ
6XAX
6XAY
7NWL
8PEQ
Enriched GO Terms of Interacting Partners
?
Extracellular Matrix
Extracellular Region
Extracellular Space
Extracellular Matrix Structural Constituent
Extracellular Matrix Structural Constituent Conferring Tensile Strength
Fibronectin Binding
Extracellular Matrix Organization
Extracellular Structure Organization
Basement Membrane
Collagen Trimer
Enzyme-linked Receptor Protein Signaling Pathway
Cell Surface Receptor Signaling Pathway
Integrin Binding
Cell Adhesion
Endoplasmic Reticulum Lumen
Cell Surface
Developmental Process
Negative Regulation Of Multicellular Organismal Process
Collagen Type IV Trimer
Integrin Complex
Signal Transduction
Negative Regulation Of Developmental Process
Regulation Of Multicellular Organismal Process
Response To Growth Factor
Cell-matrix Adhesion
Regulation Of Cell Adhesion
Extracellular Matrix Binding
Anatomical Structure Morphogenesis
Collagen-activated Tyrosine Kinase Receptor Signaling Pathway
Regulation Of Vasculature Development
Cell-cell Adhesion
Positive Regulation Of Cell Migration
Regulation Of Cell Migration
Positive Regulation Of Cell Motility
Regulation Of Developmental Process
Regulation Of Multicellular Organismal Development
Positive Regulation Of Locomotion
Regulation Of Apoptotic Process
Collagen-activated Signaling Pathway
Regulation Of Angiogenesis
Regulation Of Cell Motility
Collagen Binding
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Cell-substrate Adhesion
Cell Adhesion Mediated By Integrin
Regulation Of Cellular Response To Growth Factor Stimulus
Regulation Of Programmed Cell Death
Regulation Of Cell Population Proliferation
Regulation Of Locomotion
Integrin-mediated Signaling Pathway
Tissue Development
Epidermis Development
Integrin Binding
Positive Regulation Of Growth
Positive Regulation Of Developmental Growth
Regulation Of Growth
Regulation Of Developmental Growth
Regulation Of Cell Differentiation
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Fibroblast Proliferation
Receptor Ligand Activity
Insulin-like Growth Factor Receptor Binding
Positive Regulation Of Glycogen Biosynthetic Process
Wound Healing
Positive Regulation Of Signal Transduction
Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate
Regulation Of Cell Development
Regulation Of Nervous System Development
Insulin Receptor Binding
Positive Regulation Of Small GTPase Mediated Signal Transduction
Regulation Of Translation At Presynapse, Modulating Synaptic Transmission
Positive Regulation Of Developmental Process
Regulation Of Multicellular Organismal Process
Negative Regulation Of Gene Expression
Angiogenesis
Positive Regulation Of Cell Differentiation
Alphav-beta3 Integrin-IGF-1-IGF1R Complex
Negative Regulation Of Inner Ear Auditory Receptor Cell Differentiation
Negative Regulation Of Inner Ear Receptor Cell Differentiation
Compartment Pattern Specification
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Fibroblast Proliferation
Regulation Of Glycogen Biosynthetic Process
Basement Membrane
Negative Regulation Of Multicellular Organismal Process
Regulation Of Developmental Process
Response To Wounding
Extracellular Region
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Integrin-mediated Signaling Pathway
Positive Regulation Of Skeletal Muscle Tissue Growth
Endodermal Cell Differentiation
Positive Regulation Of D-glucose Import
Cell-matrix Adhesion
Regulation Of Neurogenesis
Regulation Of Glycogen Metabolic Process
Regulation Of Somitogenesis
Positive Regulation Of Neurogenesis
Regulation Of Skeletal Muscle Tissue Growth
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Tagcloud (Intersection)
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