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FN1 and CDKN2A
Number of citations of the paper that reports this interaction (PubMedID
21988832
)
38
Data Source:
BioGRID
(two hybrid)
FN1
CDKN2A
Description
fibronectin 1
cyclin dependent kinase inhibitor 2A
Image
GO Annotations
Cellular Component
Extracellular Region
Fibrinogen Complex
Basement Membrane
Extracellular Space
Endoplasmic Reticulum Lumen
Endoplasmic Reticulum-Golgi Intermediate Compartment
Plasma Membrane
Apical Plasma Membrane
Extracellular Matrix
Platelet Alpha Granule Lumen
Extracellular Exosome
Blood Microparticle
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Mitochondrion
Mitochondrial Matrix
Cytosol
Nuclear Body
Protein-containing Complex
Senescence-associated Heterochromatin Focus
Molecular Function
Protease Binding
Signaling Receptor Binding
Integrin Binding
Extracellular Matrix Structural Constituent
Protein Binding
Collagen Binding
Heparin Binding
Peptidase Activator Activity
Identical Protein Binding
Proteoglycan Binding
Receptor Ligand Activity
P53 Binding
DNA Binding
RNA Binding
Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity
Protein Binding
SUMO Transferase Activity
Protein Kinase Binding
NF-kappaB Binding
Ligase Inhibitor Activity
Ubiquitin-protein Transferase Inhibitor Activity
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
MDM2/MDM4 Family Protein Binding
Disordered Domain Specific Binding
Ubiquitin Ligase Inhibitor Activity
Biological Process
Angiogenesis
Regulation Of Protein Phosphorylation
Acute-phase Response
Cell-substrate Junction Assembly
Cell Adhesion
Cell-matrix Adhesion
Calcium-independent Cell-matrix Adhesion
Integrin-mediated Signaling Pathway
Nervous System Development
Heart Development
Positive Regulation Of Cell Population Proliferation
Regulation Of Cell Shape
Response To Wounding
Positive Regulation Of Gene Expression
Response To Muscle Activity
Integrin Activation
Substrate Adhesion-dependent Cell Spreading
Endodermal Cell Differentiation
Wound Healing
Endothelial Cell Migration
Positive Regulation Of Axon Extension
Positive Regulation Of Fibroblast Proliferation
Biological Process Involved In Interaction With Symbiont
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of ERK1 And ERK2 Cascade
Negative Regulation Of Transforming Growth Factor Beta Production
Blood Coagulation, Fibrin Clot Formation
Negative Regulation Of Monocyte Activation
Neural Crest Cell Migration Involved In Autonomic Nervous System Development
Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate
Negative Regulation Of Transcription By RNA Polymerase II
Protein Polyubiquitination
Autophagy Of Mitochondrion
Negative Regulation Of Cell-matrix Adhesion
RRNA Processing
Apoptotic Process
Ras Protein Signal Transduction
Negative Regulation Of Cell Population Proliferation
Epidermis Development
RRNA Transcription
Regulation Of Gene Expression
Positive Regulation Of Gene Expression
Protein Sumoylation
Keratinocyte Differentiation
Negative Regulation Of Cell Growth
Nuclear Body Organization
Negative Regulation Of B Cell Proliferation
Regulation Of Protein Stability
Protein Destabilization
Negative Regulation Of Immature T Cell Proliferation In Thymus
Positive Regulation Of Protein Sumoylation
Mammary Gland Epithelial Cell Proliferation
Negative Regulation Of Mammary Gland Epithelial Cell Proliferation
Positive Regulation Of Smooth Muscle Cell Apoptotic Process
Protein Localization To Nucleus
Somatic Stem Cell Population Maintenance
Glucose Homeostasis
Positive Regulation Of Apoptotic Process
Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Keratinocyte Proliferation
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Negative Regulation Of Cell Cycle
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Nucleocytoplasmic Transport
Regulation Of Protein Export From Nucleus
Somatic Stem Cell Division
Protein Stabilization
Regulation Of Cell Cycle
Mitochondrial Depolarization
Apoptotic Process Involved In Mammary Gland Involution
Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution
Cellular Response To Hydrogen Peroxide
Protein K63-linked Ubiquitination
Cellular Senescence
Replicative Senescence
Oncogene-induced Cell Senescence
Apoptotic Signaling Pathway
Positive Regulation Of Protein Localization To Nucleus
Positive Regulation Of Signal Transduction By P53 Class Mediator
Protein Localization To Nucleolus
Negative Regulation Of Proteolysis Involved In Protein Catabolic Process
Regulation Of Protein Targeting To Mitochondrion
Negative Regulation Of Ubiquitin Protein Ligase Activity
Amyloid Fibril Formation
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Macrophage Apoptotic Process
Negative Regulation Of Protein Neddylation
Pathways
Platelet degranulation
Degradation of the extracellular matrix
Degradation of the extracellular matrix
Fibronectin matrix formation
Cell surface interactions at the vascular wall
Molecules associated with elastic fibres
Integrin cell surface interactions
Syndecan interactions
Non-integrin membrane-ECM interactions
ECM proteoglycans
Integrin signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
MAP2K and MAPK activation
Interleukin-4 and Interleukin-13 signaling
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF1 fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
MET activates PTK2 signaling
Post-translational protein phosphorylation
GPER1 signaling
Attachment of bacteria to epithelial cells
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
ALK mutants bind TKIs
Signaling by ALK fusions and activated point mutants
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Developmental Lineage of Pancreatic Ductal Cells
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
Oncogene Induced Senescence
Cyclin D associated events in G1
Transcriptional Regulation by VENTX
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation
Apoptotic factor-mediated response
Oxidative Stress Induced Senescence
Oncogene Induced Senescence
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription factors
Regulation of TP53 Degradation
Stabilization of p53
Regulation of RUNX3 expression and activity
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function
Evasion of Oncogene Induced Senescence Due to p14ARF Defects
Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects
Nuclear events mediated by NFE2L2
Drugs
Zinc
Lanoteplase
Ocriplasmin
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Diseases
Chronic myeloid leukemia (CML)
Non-small cell lung cancer
Malignant islet cell carcinoma
Adult T-cell leukemia
Esophageal cancer
Glioma
Pancreatic cancer
Nasopharyngeal cancer
Hepatocellular carcinoma
Squamous cell carcinoma
Penile cancer
Oral cancer
Malignant melanoma
Burkitt lymphoma
Gallbladder cancer
Bladder cancer
Laryngeal cancer
Cholangiocarcinoma
Malignant pleural mesothelioma
Osteosarcoma
Type II diabetes mellitus
GWAS
Apolipoprotein B levels (
32203549
)
Cholesterol, total (
26780889
)
Coronary artery disease (
33020668
32469254
29212778
28714974
)
Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) (
28714975
)
Diastolic blood pressure (
30578418
)
Iron status biomarkers (ferritin levels) (
33536631
)
LDL cholesterol (
24097068
)
LDL cholesterol levels (
28334899
32203549
)
Lymphocyte count (
32888494
)
Monocyte count (
32888494
)
Myocardial infarction (
33532862
)
Negative urgency (
30718321
)
Pulse pressure (
30578418
28135244
27841878
)
Systolic blood pressure (
30578418
27841878
)
Total cholesterol levels (
28334899
)
White blood cell count (
32888494
)
Abdominal aortic aneurysm (
20622881
)
Acute lymphoblastic leukemia (childhood) (
29348612
)
Acute lymphoblastic leukemia in childhood (B cell precursor) (
29632299
)
B-cell acute lymphoblastic leukaemia (
31767839
)
Basal cell carcinoma (
25855136
24403052
)
Basophil count (
32888494
)
Breast cancer (
23535729
29059683
20453838
)
Coronary artery calcification (
23561647
)
Coronary artery disease (
29263402
26708285
21239051
)
Coronary heart disease (
21971053
21378990
17554300
)
Coronary heart disease (SNP X SNP interaction) (
21626137
)
Coronary heart disease x type 2 diabetes interaction (
32541925
)
Endometrial cancer (
30093612
)
Endometrial cancer (endometrioid histology) (
30093612
)
Endometriosis (
23104006
)
Eosinophil count (
32888494
)
Esophageal squamous cell carcinoma (
25129146
)
Fasting plasma glucose (
25187374
)
Glioblastoma (
28346443
)
Glioma (
21531791
28346443
19578367
)
Inflammatory bowel disease (
27569725
)
Intracranial aneurysm (
18997786
20364137
)
Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy) (
27418160
)
Lymphocyte count (
27863252
32888494
)
Lymphocyte percentage of white cells (
32888494
)
Mean corpuscular hemoglobin concentration (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Melanoma (
28212542
19578364
21983787
)
Monocyte count (
27863252
32888494
)
Multiple myeloma (
27363682
)
Myocardial infarction (
17478679
26708285
)
Myocardial infarction (early onset) (
19198609
)
Nasopharyngeal carcinoma (
26545403
)
Neutrophil percentage of white cells (
32888494
)
Non-glioblastoma glioma (
28346443
)
Non-small cell lung cancer (
31326317
)
Parental longevity (both parents in top 10%) (
29227965
)
Parental longevity (father's age at death) (
29227965
)
Platelet count (
27863252
22139419
32888494
)
Plateletcrit (
27863252
32888494
)
Red cell distribution width (
32888494
)
Reticulocyte fraction of red cells (
32888494
)
Spleen volume (
34128465
)
Type 2 diabetes (
23209189
17463246
17463248
17463249
18372903
19401414
20581827
21573907
30718926
23945395
24509480
26818947
26961502
27189021
32499647
29358691
30297969
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
White blood cell count (
27863252
32888494
)
Interacting Genes
111 interacting genes:
ADAMTS4
AMBP
ANOS1
APCS
ATXN10
ATXN7
C1QA
CCN3
CD44
CDKN2A
COL13A1
COL1A1
COL1A2
COL2A1
COL4A1
COL4A2
COL4A3
COL4A4
COL4A5
COL4A6
COL6A2
COL7A1
COL9A1
COMP
CRP
CTSD
CXCL12
DCN
DSCR9
DUSP10
EGFR
F13A1
FAM86B3P
FASLG
FBLN1
FBLN2
FST
FSTL3
GALNT6
GRB2
GSN
HGF
HOXA1
HRG
HSP90AA1
HSPG2
IGFBP3
IGFBP5
ITGA2B
ITGA3
ITGA4
ITGA5
ITGA8
ITGB1
ITGB3
ITGB6
ITGB7
KLK3
KPNA2
LACRT
LGALS3BP
LPA
LRG1
LTBP1
MAG
MATN2
MEP1A
MEP1B
MIA
MMP9
MTDH
MTNR1A
MYOC
NR0B2
NT5E
PELI2
PKD1
PLAT
PLG
PRELP
PRPF40A
RARA
RBL1
REG3A
RPS6KA5
RSPH1
SCGB1A1
SDC2
SGCA
SH3GLB1
SKIL
SMAD4
SMAD9
SPARC
STAT5A
TAB1
TAB2
TAC1
TGFBI
TGM2
THBS1
TIMD4
TLR4
TMPRSS6
TNC
TNFRSF11B
TSHR
TTN
UBQLN1
VEGFA
VHL
168 interacting genes:
-
ACLY
ACTB
ACTG1
ACTN4
AHNAK
AKT1
ALDOB
ANAPC15
ANGPTL4
ANKRA2
ANKRD12
AOPEP
ARFIP2
ARNT
ASPRV1
AZIN1
BAAT
BCL2L1
BECN1
CARF
CASC3
CCDC180
CCDC183
CCND2
CCNDBP1
CCNE1
CCNG1
CD44
CDC14B
CDC42
CDC45
CDC5L
CDC6
CDC7
CDK4
CDK6
CDKN2AIP
CDKN2C
CENPA
CRELD2
CTBP2
CTSV
CYLC2
DEAF1
E2F1
E4F1
EEF2
EFHC2
EGR1
EPHA2
EPHA3
EXOC2
FGFR4
FN1
FRAT2
GALNT12
GAPDH
GGA1
GGA3
GLIS1
GLIS2
GMNN
GSPT1
H2BC26
HGF
HIF1A
HLA-DOB
HNRNPA2B1
HNRNPC
HNRNPU
HRAS
HSP90AA1
HSP90AB1
HSPA4
HSPA8
HUWE1
ISOC2
KAT5
LATS2
MAF1
MAP2K1
MAP2K5
MAP3K5
MAPK10
MAPK14
MAPK3
MAPK8
MCM10
MCM2
MCM5
MCM6
MDM2
MDM4
MKRN1
MMRN1
MTR
MYC
MYL12A
NAT2
NCL
NMI
NOP53
NPM1
NSD3
ORC4
PCNA
PDCD6
PDGFRA
PEX19
PPP1R9B
PRKCA
PSMC3
PTP4A3
RAF1
RASA1
RASSF1
RBM26
RIN2
RPL11
RPS7
RUVBL2
SEC61B
SERTAD1
SFRP4
SGK1
SIVA1
SIX2
SLC4A1
SMARCA4
SNRPA
SNRPB
SOX3
SOX4
STK11
TBRG1
TDRD7
TEAD2
TERT
TFDP1
TGFB1
TMEFF1
TMOD1
TP63
TPI1
TRIM28
TRIP12
TSC1
TUBA1A
TUBA1C
TUBB
TUBB4B
UBC
UBE2A
UBE4B
UBL7
USP26
VAMP1
VHL
WRN
YY1
ZFP91
ZGRF1
ZNF227
ZNF410
ZNF420
ZNF687
ZUP1
Entrez ID
2335
1029
HPRD ID
00626
02542
Ensembl ID
ENSG00000115414
ENSG00000147889
Uniprot IDs
B7ZLE5
P02751
Q9UQS6
K7PML8
P42771
Q8N726
PDB IDs
1E88
1E8B
1FBR
1FNA
1FNF
1FNH
1J8K
1O9A
1OWW
1Q38
1QGB
1QO6
1TTF
1TTG
2CG6
2CG7
2CK2
2CKU
2EC3
2FN2
2FNB
2GEE
2H41
2H45
2HA1
2MNU
2N1K
2OCF
2RKY
2RKZ
2RL0
3CAL
3EJH
3GXE
3M7P
3MQL
3R8Q
3T1W
3ZRZ
4GH7
4JE4
4JEG
4LXO
4MMX
4MMY
4MMZ
4PZ5
5DC0
5DC4
5DC9
5DFT
5J6Z
5J7C
5M0A
5N47
5N48
6HNF
6MFA
6MSV
6NAJ
6XAX
6XAY
7NWL
8PEQ
1A5E
1BI7
1DC2
2A5E
7OZT
Enriched GO Terms of Interacting Partners
?
Extracellular Matrix
Extracellular Region
Extracellular Space
Extracellular Matrix Structural Constituent
Extracellular Matrix Structural Constituent Conferring Tensile Strength
Fibronectin Binding
Extracellular Matrix Organization
Extracellular Structure Organization
Basement Membrane
Collagen Trimer
Enzyme-linked Receptor Protein Signaling Pathway
Cell Surface Receptor Signaling Pathway
Integrin Binding
Cell Adhesion
Endoplasmic Reticulum Lumen
Cell Surface
Developmental Process
Negative Regulation Of Multicellular Organismal Process
Collagen Type IV Trimer
Integrin Complex
Signal Transduction
Negative Regulation Of Developmental Process
Regulation Of Multicellular Organismal Process
Response To Growth Factor
Cell-matrix Adhesion
Regulation Of Cell Adhesion
Extracellular Matrix Binding
Anatomical Structure Morphogenesis
Collagen-activated Tyrosine Kinase Receptor Signaling Pathway
Regulation Of Vasculature Development
Cell-cell Adhesion
Positive Regulation Of Cell Migration
Regulation Of Cell Migration
Positive Regulation Of Cell Motility
Regulation Of Developmental Process
Regulation Of Multicellular Organismal Development
Positive Regulation Of Locomotion
Regulation Of Apoptotic Process
Collagen-activated Signaling Pathway
Regulation Of Angiogenesis
Regulation Of Cell Motility
Collagen Binding
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Cell-substrate Adhesion
Cell Adhesion Mediated By Integrin
Regulation Of Cellular Response To Growth Factor Stimulus
Regulation Of Programmed Cell Death
Regulation Of Cell Population Proliferation
Regulation Of Locomotion
Integrin-mediated Signaling Pathway
Nucleus
Nucleoplasm
Cellular Response To Stress
Regulation Of Cell Cycle
Regulation Of Primary Metabolic Process
DNA Damage Response
Regulation Of Cell Population Proliferation
Response To Stress
Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Cell Cycle Process
Positive Regulation Of Metabolic Process
Regulation Of Cell Cycle Phase Transition
Regulation Of Protein Stability
Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Metabolic Process
Cytosol
Regulation Of DNA Metabolic Process
Regulation Of Protein Metabolic Process
Response To Radiation
Cytoplasm
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
DNA Replication Initiation
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Mitotic Cell Cycle
DNA Metabolic Process
Positive Regulation Of Biosynthetic Process
Nucleotide Binding
Regulation Of Cellular Component Organization
Macromolecule Metabolic Process
Protein-containing Complex
Negative Regulation Of Macromolecule Metabolic Process
Cellular Senescence
ATP Binding
Positive Regulation Of Cell Cycle Process
Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Regulation Of Catalytic Activity
Cellular Response To Radiation
Positive Regulation Of Transcription By RNA Polymerase II
Nucleic Acid Metabolic Process
Positive Regulation Of Cell Cycle Phase Transition
Protein Stabilization
Regulation Of Signal Transduction By P53 Class Mediator
Positive Regulation Of DNA Metabolic Process
Positive Regulation Of Fibroblast Proliferation
Nucleobase-containing Compound Metabolic Process
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