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SMAD9 and LEMD3
Number of citations of the paper that reports this interaction (PMID
15231748
)
65
Data Source:
HPRD
(two hybrid)
SMAD9
LEMD3
Gene Name
SMAD family member 9
LEM domain containing 3
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Intracellular
Nucleus
Nucleoplasm
Transcription Factor Complex
Cytoplasm
Cytosol
Nuclear Inner Membrane
Integral Component Of Nuclear Inner Membrane
Membrane
Integral Component Of Membrane
Molecular Function
DNA Binding
Sequence-specific DNA Binding Transcription Factor Activity
Protein Binding
Transforming Growth Factor Beta Receptor, Pathway-specific Cytoplasmic Mediator Activity
Metal Ion Binding
Nucleotide Binding
DNA Binding
Protein Binding
Biological Process
Ureteric Bud Development
Response To Hypoxia
Mullerian Duct Regression
Transcription, DNA-templated
Protein Phosphorylation
Transforming Growth Factor Beta Receptor Signaling Pathway
BMP Signaling Pathway
Midbrain Development
Hindbrain Development
Intracellular Signal Transduction
Positive Regulation Of Cell Differentiation
Positive Regulation Of Transcription, DNA-templated
Cartilage Development
Bone Development
Cellular Response To Organic Cyclic Compound
Blood Vessel Endothelial Cell Migration Involved In Intussusceptive Angiogenesis
Nucleus Organization
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of BMP Signaling Pathway
Negative Regulation Of Activin Receptor Signaling Pathway
Skeletal Muscle Cell Differentiation
Regulation Of Cell Cycle
Regulation Of Extracellular Matrix Organization
Pathways
Signaling by BMP
Mitotic Prophase
Nuclear Envelope Breakdown
Depolymerisation of the Nuclear Lamina
Nuclear Envelope Reassembly
Clearance of Nuclear Envelope Membranes from Chromatin
Mitotic Anaphase
Initiation of Nuclear Envelope Reformation
Mitotic Metaphase and Anaphase
Cell Cycle, Mitotic
M Phase
Drugs
Diseases
GWAS
Protein-Protein Interactions
117 interactors:
ABTB1
ACTB
ACVR1
AFF1
AP2A1
ARHGAP9
ARID1B
ARNT
ASB2
ASH2L
BAZ1A
BTG2
C10orf2
CAMSAP1
CEP135
CHPF
CLPB
CPXM2
CSH1
CSH2
CTR9
CXXC5
CYP11A1
DIAPH3
DKK1
DNAJA3
DNAJC7
DST
DSTN
E4F1
EIF3C
EIF3E
EIF3F
ERVV-1
EVC2
EXPH5
FLI1
FN1
FTL
GRN
HEY1
HEYL
HUWE1
KDM1A
KDM6A
KIAA0226
KMT2D
LEMD3
LMO4
LNPEP
LRP5
MAN1A2
MAN1C1
MAN2B1
MBD1
MCM3AP
METAP1
MGAT1
MTMR10
MTMR11
NAGK
OTUB1
PABPC4
PAPPA
PELP1
PHKA2
PIR
PKP2
PLEC
PNPLA2
PPARD
PPP2R5E
PRMT6
PSAP
PSMD8
QARS
RANBP9
RFX1
RMND5A
RNF123
RRBP1
SECISBP2
SF3B1
SIL1
SMAD2
SMAD3
SMAD4
SMG1
SNRNP70
SPTBN1
STAG1
SVEP1
TBCD
TERF1
TINAGL1
TMEM57
TOB1
TRIM29
TRIP12
TTC37
UBA6
UBE3A
UBQLN1
UBQLN4
UNC45A
VCPIP1
VPS8
XAB2
YWHAQ
ZEB2
ZNF484
ZNF557
ZNF587
ZNF587B
ZNF592
ZNF83
ZSCAN4
4 interactors:
BCLAF1
SMAD1
SMAD2
SMAD9
Entrez ID
4093
23592
HPRD ID
04484
09704
Ensembl ID
ENSG00000120693
ENSG00000174106
Uniprot IDs
O15198
Q9Y2U8
PDB IDs
2CH0
Enriched GO Terms of Interacting Partners
?
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Gene Expression
Cellular Metabolic Process
Transcription, DNA-templated
Biosynthetic Process
RNA Metabolic Process
RNA Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Regulation Of Metabolic Process
Cellular Process
Cellular Protein Metabolic Process
Protein Metabolic Process
Regulation Of Gene Expression
Nucleobase-containing Compound Metabolic Process
Gastrulation
Anterior/posterior Pattern Specification
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Positive Regulation Of Gene Expression
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Protein Metabolic Process
Positive Regulation Of Transcription, DNA-templated
Negative Regulation Of Gene Expression
Developmental Process
Cellular Nitrogen Compound Metabolic Process
Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Multicellular Organismal Development
Atrioventricular Valve Morphogenesis
Endoderm Development
Nitrogen Compound Metabolic Process
Formation Of Primary Germ Layer
Cell Differentiation
Atrioventricular Valve Development
Regulation Of Transcription From RNA Polymerase II Promoter
Anatomical Structure Development
Transcription From RNA Polymerase II Promoter
Organ Development
Negative Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Metabolic Process
Embryo Development
Negative Regulation Of RNA Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
SMAD Protein Complex Assembly
Posttranscriptional Regulation Of Gene Expression
Negative Regulation Of Transcription, DNA-templated
Pattern Specification Process
Primary MiRNA Processing
Ureteric Bud Development
Mesonephric Tubule Development
Mesonephric Epithelium Development
Mesonephros Development
Transforming Growth Factor Beta Receptor Signaling Pathway
Kidney Epithelium Development
SMAD Protein Complex Assembly
Cellular Response To Transforming Growth Factor Beta Stimulus
Response To Transforming Growth Factor Beta
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Production Of MiRNAs Involved In Gene Silencing By MiRNA
Kidney Development
Renal System Development
Positive Regulation Of Transcription, DNA-templated
Gene Silencing By MiRNA
Cellular Response To DsRNA
Urogenital System Development
Posttranscriptional Gene Silencing
Positive Regulation Of Macromolecule Biosynthetic Process
Cellular Response To Organic Cyclic Compound
Positive Regulation Of Gene Expression
Positive Regulation Of Cellular Biosynthetic Process
Gene Silencing By RNA
Skeletal System Development
Cellular Response To Growth Factor Stimulus
Response To DsRNA
BMP Signaling Pathway
Response To Growth Factor
Mesoderm Formation
Midbrain Development
Embryonic Pattern Specification
Mesoderm Morphogenesis
Organ Growth
Transcription, DNA-templated
Tube Development
RNA Biosynthetic Process
Gene Silencing
Positive Regulation Of Cellular Metabolic Process
Formation Of Primary Germ Layer
Positive Regulation Of Cell Differentiation
Mesoderm Development
Response To Organic Cyclic Compound
Enzyme Linked Receptor Protein Signaling Pathway
Positive Regulation Of Cell Morphogenesis Involved In Differentiation
Hindbrain Development
Positive Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry
RNA Metabolic Process
Gastrulation
Epithelium Development
Tagcloud
?
12q13
12q14
3q14
3q15
atrial
autism
bands
centres
comprising
delay
deleted
deletions
ductus
dysmorphism
encompassing
ended
extends
facial
hmga2
microdeletions
osteopoikilosis
overlapping
overlaps
patent
septal
speech
stature
stenosis
subtle
Tagcloud (Difference)
?
12q13
12q14
3q14
3q15
atrial
autism
bands
centres
comprising
delay
deleted
deletions
ductus
dysmorphism
encompassing
ended
extends
facial
hmga2
microdeletions
osteopoikilosis
overlapping
overlaps
patent
septal
speech
stature
stenosis
subtle
Tagcloud (Intersection)
?